Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jun 15, 2024; 15(6): 1291-1298
Published online Jun 15, 2024. doi: 10.4239/wjd.v15.i6.1291
Therapeutic effects of Lingguizhugan decoction in a rat model of high-fat diet-induced insulin resistance
Xiao-Ming Liu, Shi-Qing Yuan, Ying Ning, Shi-Jia Nie, Xu-Qiong Wang, Hong-Yi Jia, Xiu-Li Zheng
Xiao-Ming Liu, Shi-Qing Yuan, Ying Ning, Shi-Jia Nie, Xu-Qiong Wang, Xiu-Li Zheng, Department of Basic Medicine, School of Basic Medicine Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan Province, China
Hong-Yi Jia, Department of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China
Author contributions: Liu XM contributed to the formal analysis and writing of the original draft; Ning Y provided resources and conceptualization; Nie SJ was responsible for the data collection; Wang XQ conducted the investigation; Jia HY also contributed to the investigation; Zheng XL was involved in the writing, review, and editing process; Yuan SQ supervised the project and acquired funding.
Supported by the Preresearch Project of the National Natural Science Foundation of China, No. ZRYY1906; the Applied Basic Research Project of the Science and Technology Department of Sichuan Province, No. 2021YJ0154; the Talent Research Promotion Plan of Xinglin Scholars of Chengdu University of Traditional Chinese Medicine, No. QNXZ2019035; and the Chengdu University of Traditional Chinese Medicine ‘Xinglin Scholars' subject talent research promotion Program (young scholars), No. QNXZ2019037.
Institutional animal care and use committee statement: The study was reviewed and approved by the Animal Care and Use Committee of Chengdu University of Traditional Chinese Medicine (Approval No. 2024020).
Conflict-of-interest statement: Dr. Zhen has nothing to disclose.
Data sharing statement: The data are available on reasonable request.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiu-Li Zheng, Department of Basic Medicine, School of Basic Medicine Chengdu University of Traditional Chinese Medicine, No. 1166 Liutai Avenue, Wenjiang District, Chengdu 611137, Sichuan Province, China. zhengxl023@163.com
Received: November 28, 2023
Revised: February 6, 2024
Accepted: March 29, 2024
Published online: June 15, 2024
Processing time: 196 Days and 0.8 Hours
Core Tip

Core Tip: This research examines the therapeutic properties of Lingguizhugan (LGZG) decoction, specifically focusing on its potential impact on insulin resistance (IR) and its associated mechanisms. The findings indicate that the LGZG decoction effectively controls the S6 kinase beta 1 metabolic pathway, enhancing IR, weight management, glucose tolerance, and liver steatosis. The findings of this study indicate that LGZG decoction can be used as a medical treatment for the control of IR. These results offer valuable clinical insights and propose avenues for future pharmacological investigations.