Regulatory role of peroxynitrite in advanced glycation end products mediated diabetic cardiovascular complications

doi:10.4239/wjd.v15.i3.572

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World Journal of Diabetes

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World J Diabetes. Mar 15, 2024; 15(3): 572-574
Published online Mar 15, 2024. doi: 10.4239/wjd.v15.i3.572

Regulatory role of peroxynitrite in advanced glycation end products mediated diabetic cardiovascular complications

Asis Bala

Asis Bala, Pharmacology and Drug Discovery Research Laboratory, Division of Life Sciences, Institute of Advanced Study in Science and Technology, Guwahati 781035, Assam, India

Author contributions: Bala A solely planned and wrote the manuscript.

Conflict-of-interest statement: No conflict of interest to declare.

Corresponding author: Asis Bala, PhD, Associate Professor, Pharmacology and Drug Discovery Research Laboratory, Division of Life Sciences, Institute of Advanced Study in Science and Technology, Vigyan Path, Guwahati 781035, Assam, India. asisbala@iasst.gov.in

Received: November 28, 2023
Peer-review started: November 28, 2023
First decision: January 15, 2024
Revised: January 15, 2024
Accepted: February 6, 2024
Article in press: February 6, 2024
Published online: March 15, 2024
Processing time: 107 Days and 22.5 Hours

Core Tip

Core Tip: The binding of Advanced Glycation End Products (AGE) to its receptor triggers the activation of signaling mediators that promote the generation of reactive oxygen species (ROS). The impact of ROS on the body can be beneficial or harmful, depending on its concentration and location. In diabetic cardiovascular complications, peroxynitrite (ONOO^-) plays a crucial role in vascular changes. ROS, derived from NADPH oxidase, regulates host immune responses and cellular inflammation. The production of superoxide (O₂^-), hydrogen peroxide (H₂O₂), and other compounds occurs as oxygen undergoes a series of reductions. It is essential to consider the presence of ONOO^- in AGEs in diabetic cardiovascular complications.