Meta-Analysis
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Aug 15, 2023; 14(8): 1301-1313
Published online Aug 15, 2023. doi: 10.4239/wjd.v14.i8.1301
New environmental factors related to diabetes risk in humans: Emerging bisphenols used in synthesis of plastics
Rafael Moreno-Gómez-Toledano, María Delgado-Marín, Alberto Cook-Calvete, Claudia González-Cucharero, Nunzio Alcharani, Beatriz Jiménez-Guirado, Ignacio Hernandez, Rafael Ramirez-Carracedo, Laura Tesoro, Laura Botana, Sandra Sánchez-Esteban, Javier Diez-Mata, Jose Luis Zamorano, Ricardo J. Bosch, Carlos Zaragoza, Marta Saura
Rafael Moreno-Gómez-Toledano, María Delgado-Marín, Alberto Cook-Calvete, Sandra Sánchez-Esteban, Ricardo J. Bosch, Marta Saura, Universidad de Alcalá,Department of Biological Systems/Physiology, Alcalá de Henares 28871, Spain
Rafael Moreno-Gómez-Toledano, Claudia González-Cucharero, Nunzio Alcharani, Beatriz Jiménez-Guirado, Ignacio Hernandez, Rafael Ramirez-Carracedo, Laura Tesoro, Laura Botana, Javier Diez-Mata, Jose Luis Zamorano, Carlos Zaragoza, Cardiology Department, University Hospital Ramón y Cajal, Madrid 28034, Spain
Rafael Moreno-Gómez-Toledano, Claudia González-Cucharero, Nunzio Alcharani, Beatriz Jiménez-Guirado, Ignacio Hernandez, Rafael Ramirez-Carracedo, Laura Tesoro, Laura Botana, Javier Diez-Mata, Carlos Zaragoza, Laboratory of Cardiovascular Pathophysiology, Joint Translational Research Unit, University Francisco de Vitoria School of Medicine, Madrid 28034, Spain
Rafael Moreno-Gómez-Toledano, Claudia González-Cucharero, Nunzio Alcharani, Beatriz Jiménez-Guirado, Ignacio Hernandez, Rafael Ramirez-Carracedo, Laura Tesoro, Laura Botana, Javier Diez-Mata, Jose Luis Zamorano, Carlos Zaragoza, Instituto Ramón y Cajal de Investigación Sanitaria-IRYCIS, Madrid 28034, Spain
Author contributions: Moreno-Gómez-Toledano R contributed to conceptualization; Moreno-Gómez-Toledano R, Delgado-Marín M, Cook-Calvete A contributed to the systematic review; Moreno-Gómez-Toledano R, González-Cucharero C, Alcharani N, Jiménez-Guirado B, Hernández I, Ramírez-Carracedo R, Tesoro L, Botana L, Sánchez-Esteban S, and Díez-Mata J contributed to the qualitative analysis; Moreno-Gómez-Toledano R contributed to data curation, formal analysis, methodology, and writing the original draft; Saura M, Zaragoza C, Bosch RJ, and Zamorano JL contributed to funding acquisition; Moreno-Gómez-Toledano R, Delgado-Marín M, Cook-Calvete A, González-Cucharero C, Alcharani N, Jiménez-Guirado B, Hernández I, Ramírez-Carracedo R, Tesoro L, Botana L, Sánchez-Esteban S, and Díez-Mata J contributed to the investigation; Saura M, Zaragoza C, Bosch RJ, and Zamorano JL contributed to project administration; Moreno-Gómez-Toledano R, Saura M, Zaragoza C, Bosch RJ, and Zamorano JL contributed to writing and editing the review; and all authors have read and agreed to the published version of the manuscript.
Supported by the “Margarita Salas” postdoctoral fellowship from the Universidad de Alcalá; and FPI fellowships from the Universidad de Alcalá.
Conflict-of-interest statement: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rafael Moreno-Gómez-Toledano, PhD, Assistant Professor, Postdoctoral Fellow, Research Scientist, Universidad de Alcalá, Department of Biological Systems/Physiology, Facultad de Medicina-Campus Universitario-C/ 19, Av. De Madrid, Km 33600, Alcalá de Henares 28871, Spain. r.morenogomeztoledano@gmail.com
Received: March 28, 2023
Peer-review started: March 28, 2023
First decision: May 8, 2023
Revised: May 21, 2023
Accepted: June 5, 2023
Article in press: June 5, 2023
Published online: August 15, 2023
Processing time: 135 Days and 15.6 Hours
Core Tip

Core tip: The present study analyzed the potential dangers that society faces with the replacement of bisphenol A (BPA) by new BPs. Thus, using PRISMA methodologies, a systematic review and meta-analysis of the relationship between new BPs and diabetes mellitus (DM) in humans was carried out. The results showed a positive relationship between BPS, BPF and BPAF and DM, which was statistically significant only with BPS. Consequently, new BPs could represent a health risk equivalent to that of BPA.