Lim PQ, Lai YJ, Ling PY, Chen KH. Cellular and molecular overview of gestational diabetes mellitus: Is it predictable and preventable? World J Diabetes 2023; 14(11): 1693-1709 [PMID: 38077798 DOI: 10.4239/wjd.v14.i11.1693]
Corresponding Author of This Article
Kuo-Hu Chen, MD, MSc, PhD, Academic Editor, Attending Doctor, Chief Physician, Director, Professor, Senior Editor, Senior Researcher, Surgical Oncologist, Teacher, Department of Obstetrics and Gynecology, Taipei Tzu-Chi Hospital, The Buddhist Tzu-Chi Medical Foundation, No. 289 Jianguo Road, 231 Xindian, Taipei 231, Taiwan. alexgfctw@yahoo.com.tw
Research Domain of This Article
Obstetrics & Gynecology
Article-Type of This Article
Systematic Reviews
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Lim PQ, Lai YJ, Ling PY, Chen KH. Cellular and molecular overview of gestational diabetes mellitus: Is it predictable and preventable? World J Diabetes 2023; 14(11): 1693-1709 [PMID: 38077798 DOI: 10.4239/wjd.v14.i11.1693]
Pei-Qi Lim, Yen-Ju Lai, Pei-Ying Ling, Department of Obstetrics and Gynecology, Taiwan Adventist Hospital, Taipei 105, Taiwan
Pei-Ying Ling, School of Medicine, George Washington University, Washington, DC 20052, United States
Kuo-Hu Chen, Department of Obstetrics and Gynecology, Taipei Tzu-Chi General Hospital, Taipei 231, Taiwan
Kuo-Hu Chen, School of Medicine, Tzu-Chi University, Hualien 970, Taiwan
Author contributions: Lim PQ and Chen KH designed the research study; Lim PQ, Lai YJ, Ling PY, and Chen KH performed the research; Lim PQ, Lai YJ, and Chen KH analyzed the data; Lim PQ, Lai YJ, and Chen KH wrote the manuscript; All authors read and approved the final manuscript.
Conflict-of-interest statement: The authors declare having no conflicts of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Corresponding author: Kuo-Hu Chen, MD, MSc, PhD, Academic Editor, Attending Doctor, Chief Physician, Director, Professor, Senior Editor, Senior Researcher, Surgical Oncologist, Teacher, Department of Obstetrics and Gynecology, Taipei Tzu-Chi Hospital, The Buddhist Tzu-Chi Medical Foundation, No. 289 Jianguo Road, 231 Xindian, Taipei 231, Taiwan. alexgfctw@yahoo.com.tw
Received: February 26, 2023 Peer-review started: February 26, 2023 First decision: April 20, 2023 Revised: May 18, 2023 Accepted: October 11, 2023 Article in press: October 11, 2023 Published online: November 15, 2023 Processing time: 260 Days and 22.9 Hours
Core Tip
Core Tip: Maternal and fetal effects of uncontrolled gestational diabetes mellitus (GDM) include stillbirth, macrosomia, neonatal diabetes, and birth trauma. Risk factors are maternal obesity or overweight, pre-existing diabetes mellitus, and polycystic ovary syndrome. The complex pathophysiology involves genetic variants, pancreatic β cell depletion or dysfunction, aggravated insulin resistance due to glucose transporter 4 translocation failure, and chronic, low-grade inflammation. Antepartum measurements including adipokines (leptin), body mass ratio (waist circumference and waist-to-hip ratio), and biomarkers (microRNA in extracellular vesicles) are useful markers for predicting GDM. For preventing GDM, physical activity and diet (such as the Mediterranean diet) control are effective interventions.
