Lim PQ, Lai YJ, Ling PY, Chen KH. Cellular and molecular overview of gestational diabetes mellitus: Is it predictable and preventable? World J Diabetes 2023; 14(11): 1693-1709 [PMID: 38077798 DOI: 10.4239/wjd.v14.i11.1693]
Corresponding Author of This Article
Kuo-Hu Chen, MD, MSc, PhD, Academic Editor, Attending Doctor, Chief Physician, Director, Professor, Senior Editor, Senior Researcher, Surgical Oncologist, Teacher, Department of Obstetrics and Gynecology, Taipei Tzu-Chi Hospital, The Buddhist Tzu-Chi Medical Foundation, No. 289 Jianguo Road, 231 Xindian, Taipei 231, Taiwan. alexgfctw@yahoo.com.tw
Research Domain of This Article
Obstetrics & Gynecology
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Pei-Qi Lim, Yen-Ju Lai, Pei-Ying Ling, Department of Obstetrics and Gynecology, Taiwan Adventist Hospital, Taipei 105, Taiwan
Pei-Ying Ling, School of Medicine, George Washington University, Washington, DC 20052, United States
Kuo-Hu Chen, Department of Obstetrics and Gynecology, Taipei Tzu-Chi General Hospital, Taipei 231, Taiwan
Kuo-Hu Chen, School of Medicine, Tzu-Chi University, Hualien 970, Taiwan
Author contributions: Lim PQ and Chen KH designed the research study; Lim PQ, Lai YJ, Ling PY, and Chen KH performed the research; Lim PQ, Lai YJ, and Chen KH analyzed the data; Lim PQ, Lai YJ, and Chen KH wrote the manuscript; All authors read and approved the final manuscript.
Conflict-of-interest statement: The authors declare having no conflicts of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Kuo-Hu Chen, MD, MSc, PhD, Academic Editor, Attending Doctor, Chief Physician, Director, Professor, Senior Editor, Senior Researcher, Surgical Oncologist, Teacher, Department of Obstetrics and Gynecology, Taipei Tzu-Chi Hospital, The Buddhist Tzu-Chi Medical Foundation, No. 289 Jianguo Road, 231 Xindian, Taipei 231, Taiwan. alexgfctw@yahoo.com.tw
Received: February 26, 2023 Peer-review started: February 26, 2023 First decision: April 20, 2023 Revised: May 18, 2023 Accepted: October 11, 2023 Article in press: October 11, 2023 Published online: November 15, 2023 Processing time: 260 Days and 22.9 Hours
Core Tip
Core Tip: Maternal and fetal effects of uncontrolled gestational diabetes mellitus (GDM) include stillbirth, macrosomia, neonatal diabetes, and birth trauma. Risk factors are maternal obesity or overweight, pre-existing diabetes mellitus, and polycystic ovary syndrome. The complex pathophysiology involves genetic variants, pancreatic β cell depletion or dysfunction, aggravated insulin resistance due to glucose transporter 4 translocation failure, and chronic, low-grade inflammation. Antepartum measurements including adipokines (leptin), body mass ratio (waist circumference and waist-to-hip ratio), and biomarkers (microRNA in extracellular vesicles) are useful markers for predicting GDM. For preventing GDM, physical activity and diet (such as the Mediterranean diet) control are effective interventions.
Share the Article
Lim PQ, Lai YJ, Ling PY, Chen KH. Cellular and molecular overview of gestational diabetes mellitus: Is it predictable and preventable? World J Diabetes 2023; 14(11): 1693-1709 [PMID: 38077798 DOI: 10.4239/wjd.v14.i11.1693]
