©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. May 15, 2022; 13(5): 417-419
Published online May 15, 2022. doi: 10.4239/wjd.v13.i5.417
Published online May 15, 2022. doi: 10.4239/wjd.v13.i5.417
Concomitant dysregulation of androgen secretion and dysfunction of adipose tissue induced insulin resistance
Marwan SM Al-Nimer, Department of Clinical Pharmacology and Therapeutics, College of Medicine, University of Diyala, Baqubah 32001, Diyala, Iraq
Author contributions: Al-Nimer MS wrote and revised the letter.
Conflict-of-interest statement: The author declares no conflict of interest.
Corresponding author: Marwan SM Al-Nimer, MBChB, MD, PhD, Professor, Department of Clinical Pharmacology and Therapeutics, College of Medicine, University of Diyala, University Street, Baqubah 32001, Diyala, Iraq. alnimermarwan@ymail.com
Received: May 10, 2021
Peer-review started: May 10, 2021
First decision: September 5, 2021
Revised: September 7, 2021
Accepted: April 25, 2022
Article in press: April 25, 2022
Published online: May 15, 2022
Processing time: 367 Days and 14.2 Hours
Peer-review started: May 10, 2021
First decision: September 5, 2021
Revised: September 7, 2021
Accepted: April 25, 2022
Article in press: April 25, 2022
Published online: May 15, 2022
Processing time: 367 Days and 14.2 Hours
Core Tip
Core Tip: There is a close relationship between hyperinsulinemia and androgen excess in patients with androgen excess disorders. These disorders result from the dysfunction of gonad and adipose cells under the influence of a specific trigger. Sodium valproate is an example of an external trigger that produces concomitant hyperinsulinemia and androgenism leading to polycystic ovary syndrome. Therefore, elimination of the triggers can lead to recovery from antiepileptic drugs while using insulin sensitizers and/or anti-androgens can help to solve this pathological problem.