Diabetes and COVID-19: Role of insulin resistance as a risk factor for COVID-19 severity

doi:10.4239/wjd.v12.i9.1550

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Sep 15, 2021; 12(9): 1550-1562
Published online Sep 15, 2021. doi: 10.4239/wjd.v12.i9.1550

Diabetes and COVID-19: Role of insulin resistance as a risk factor for COVID-19 severity

Charitha Gangadharan, Rupa Ahluwalia, Alben Sigamani

Charitha Gangadharan, Department of Clinical Research, Narayana Hrudayalaya Limited, Bangalore 560099, Karnataka, India

Rupa Ahluwalia, Consultant in Diabetes and Endocrinology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich NR4 7UY, United Kingdom

Alben Sigamani, Chief Scientific Officer, Numen Health, Bangalore 560095, Karnataka, India

Author contributions: Sigamani A conceived the idea; Gangadharan C wrote the first draft; Ahluwalia R contributed to the review, restructuring and modifications of the final draft; All the authors contributed for structuring and improvement of the final draft, and all approved the final draft.

Conflict-of-interest statement: The authors declare no conflicts of interest.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Alben Sigamani, MBBS, MD, MSc, Professor, Chief Scientific Officer, Numen Health, No. 19, 4^th C Cross Koramangala Industrial, 5^th Block, Area, Bengaluru 560095, Karnataka, India. dralbens@numenhealth.com

Received: February 19, 2021
Peer-review started: February 19, 2021
First decision: May 12, 2021
Revised: June 11, 2021
Accepted: July 30, 2021
Article in press: July 30, 2021
Published online: September 15, 2021
Processing time: 199 Days and 21.1 Hours

Core Tip

Core Tip: Diabetes has been associated with an increased risk of developing coronavirus disease 2019 (COVID-19) as well as more severe outcomes as a consequence. The pathogenetic link between insulin resistance and COIVD-19 disease severity is not fully understood. Establishing an association between insulin resistance and COVID-19 severity can help to develop targeted therapeutic interventions and potentially improve outcomes amongst the at-risk group.