Diabetes and inflammatory diseases: An overview from the perspective of Ca2+/3'-5'-cyclic adenosine monophosphate signaling

doi:10.4239/wjd.v12.i6.767

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Jun 15, 2021; 12(6): 767-779
Published online Jun 15, 2021. doi: 10.4239/wjd.v12.i6.767

Diabetes and inflammatory diseases: An overview from the perspective of Ca²⁺/3'-5'-cyclic adenosine monophosphate signaling

Leandro Bueno Bergantin

Leandro Bueno Bergantin, Department ofPharmacology, Universidade Federal de São Paulo, São Paulo 04039-032, Brazil

Author contributions: Bergantin LB is the sole author; Bergantin L participated in the whole process of the study.

Conflict-of-interest statement: The author declares no conflict of interest, financial or otherwise.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Leandro Bueno Bergantin, PhD, Professor, Department of Pharmacology, Universidade Federal de São Paulo, Rua Pedro de Toledo, 669–Vila Clementino, São Paulo 04039-032, Brazil. leanbio39@yahoo.com.br

Received: December 2, 2020
Peer-review started: December 2, 2020
First decision: December 24, 2020
Revised: December 29, 2020
Accepted: March 7, 2021
Article in press: March 7, 2021
Published online: June 15, 2021
Processing time: 183 Days and 23.3 Hours

Core Tip

Core Tip: There are several reviews in the literature on diabetes and inflammatory diseases. Nonetheless, to my knowledge, this is the first review which clearly discusses the role of Ca²⁺/3'-5'-cyclic adenosine monophosphate (cAMP) signaling in the link between diabetes and inflammatory diseases. This article also includes a timeline of the major events in Ca²⁺/cAMP signaling, and discusses recent reports on the role of Ca²⁺ channel blockers for preventing Ca²⁺ signaling disruption due to coronavirus disease 2019 (COVID-19), including the correlation between COVID-19 and diabetes.