Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Nov 15, 2021; 12(11): 1832-1855
Published online Nov 15, 2021. doi: 10.4239/wjd.v12.i11.1832
Anti-diabetics and antimicrobials: Harmony of mutual interplay
Wael A H Hegazy, Azza A H Rajab, Amr S Abu Lila, Hisham A Abbas
Wael A H Hegazy, Azza A H Rajab, Hisham A Abbas, Department of Microbiology and Immunology, Zagazig University, Zagzig 44519, Egypt
Amr S Abu Lila, Department of Pharmaceutics, Zagazig University, Faculty of Pharmacy, Zagzig 44519, Egypt
Amr S Abu Lila, Department of Pharmaceutics, College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia
Author contributions: Hegazy WAH and Rajab AAH wrote the paper; Abu Lila AS and Abbas HA performed the collected the data.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wael A H Hegazy, PhD, Professor, Department of Microbiology and Immunology, Zagazig University, Faculty of Pharmacy, Zagzig 44519, Egypt. waelmhegazy@daad-alumni.de
Received: May 3, 2021
Peer-review started: May 3, 2021
First decision: June 16, 2021
Revised: June 26, 2021
Accepted: October 25, 2021
Article in press: October 25, 2021
Published online: November 15, 2021
Processing time: 196 Days and 0.4 Hours
Core Tip

Core Tip: Understanding the mutual interplay between diabetes and microbial infection is necessary to control both and to avoid a lot of serious complications that may happen in such clinical conditions. Repurposing of approved drugs and investigation of their new application represents a promising approach for maximizing treatment outcomes. In this review, we shed light on the overlapping areas of efficacy between anti-diabetics and antimicrobials.