Fontaine J, Tavernier G, Morin N, Carpéné C. Vanadium-dependent activation of glucose transport in adipocytes by catecholamines is not mediated via adrenoceptor stimulation or monoamine oxidase activity. World J Diabetes 2020; 11(12): 622-643 [PMID: 33384769 DOI: 10.4239/wjd.v11.i12.622]
Corresponding Author of This Article
Christian Carpéné, PhD, Senior Researcher, Institut des Maladies Métaboliques et Cardiovasculaires, Institut National de la Santé et de la Recherche Médicale, INSERM UMR1048, Université Paul Sabatier Toulouse III, CHU Rangueil, Toulouse 31432, France. christian.carpene@inserm.fr
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Basic Study
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Fontaine J, Tavernier G, Morin N, Carpéné C. Vanadium-dependent activation of glucose transport in adipocytes by catecholamines is not mediated via adrenoceptor stimulation or monoamine oxidase activity. World J Diabetes 2020; 11(12): 622-643 [PMID: 33384769 DOI: 10.4239/wjd.v11.i12.622]
World J Diabetes. Dec 15, 2020; 11(12): 622-643 Published online Dec 15, 2020. doi: 10.4239/wjd.v11.i12.622
Vanadium-dependent activation of glucose transport in adipocytes by catecholamines is not mediated via adrenoceptor stimulation or monoamine oxidase activity
Jessica Fontaine, Geneviève Tavernier, Nathalie Morin, Christian Carpéné
Jessica Fontaine, Geneviève Tavernier, Nathalie Morin, Christian Carpéné, Institut des Maladies Métaboliques et Cardiovasculaires, Institut National de la Santé et de la Recherche Médicale, INSERM UMR1048, Université Paul Sabatier Toulouse III, Toulouse 31432, France
Nathalie Morin, INSERM UMR 1139 Faculté de Pharmacie, Université de Paris, Paris 75006, France
Author contributions: Carpéné C designed the studies, performed the rat experiments, reviewed the literature, and wrote the manuscript; Tavernier G performed the mouse experiments, contributed to the literature review and revised the manuscript; Fontaine J isolated the cells for in vitro studies; Morin N was involved in the generation and analysis of the data.
Institutional review board statement: The study was approved by the I2MC Institutional Review Board: Institut des maladies métaboliques et cadiovasculaires.
Institutional animal care and use committee statement: Mice were housed and manipulated according to the INSERM guidelines and European Directive 2010/63/UE by competent and expert technicians or researchers in animal care facilities with agreement number A 31 555 04 and C 31 555 07. The experimental protocol was approved by the local ethical committee CEEA nb122.
Conflict-of-interest statement: The authors declare no competing financial interests.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guideline.
Corresponding author: Christian Carpéné, PhD, Senior Researcher, Institut des Maladies Métaboliques et Cardiovasculaires, Institut National de la Santé et de la Recherche Médicale, INSERM UMR1048, Université Paul Sabatier Toulouse III, CHU Rangueil, Toulouse 31432, France. christian.carpene@inserm.fr
Received: August 31, 2020 Peer-review started: August 31, 2020 First decision: October 5, 2020 Revised: October 12, 2020 Accepted: October 26, 2020 Article in press: October 26, 2020 Published online: December 15, 2020 Processing time: 103 Days and 18 Hours
Core Tip
Core Tip: In rat and mouse fat cells, the combination of catecholamines with vanadium reproduces the sugar entry activation already reported for benzylamine, methylamine or tyramine. Glucose transport stimulation is observed only with catecholamines at millimolar doses and in the presence of a vanadium dose that is ineffective on its own. The synergism between adrenaline or noradrenaline and vanadate is not mediated by adrenoceptors and resists amine oxidase inhibitors; while it is sensitive to antioxidants. Since vanadium exhibits antidiabetic properties, but with toxicological concerns, it is proposed that the combination of catecholamine derivatives plus vanadate salts might generate complexes with safer blood glucose-lowering properties.
