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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jul 15, 2019; 10(7): 396-402
Published online Jul 15, 2019. doi: 10.4239/wjd.v10.i7.396
Published online Jul 15, 2019. doi: 10.4239/wjd.v10.i7.396
Epidermal growth factor receptor rs17337023 polymorphism in hypertensive gestational diabetic women: A pilot study
Russell S Martins, Taimur Ahmed, Medical College, Aga Khan University, Karachi, Sindh 74800, Pakistan
Sabah Farhat, Syeda Sadia Fatima, Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Sindh 74800, Pakistan
Sana Shahid, Department of Physiology, Sir Syed Medical College for Girls, Karachi, Pakistan
Author contributions: Fatima SS and Shahid S designed research; Martins RS, Ahmed T and Farhat S performed research; Fatima SS and Shahid S contributed new reagents/analytic tools; Fatima SS analyzed data; and all authors wrote the paper and approved for publication.
Supported by Pakistan Health Research Counsel , No. 119/2016/RDC/AKU .
Institutional review board statement: The institutional ethics committee approved the research protocol, No. # 4523-BBS-ERC-16.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
ARRIVE guidelines statement: The manuscript abides the guidelines
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Syeda Sadia Fatima, MD, MPhil, PhD, Assistant Professor, Doctor, Dr, Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Sindh 74800, Pakistan. sadia.fatima@aku.edu
Telephone: +92-2134864564
Received: March 20, 2019
Peer-review started: March 22, 2019
First decision: May 31, 2019
Revised: June 10, 2019
Accepted: June 21, 2019
Article in press: June 21, 2019
Published online: July 15, 2019
Processing time: 118 Days and 3.9 Hours
Peer-review started: March 22, 2019
First decision: May 31, 2019
Revised: June 10, 2019
Accepted: June 21, 2019
Article in press: June 21, 2019
Published online: July 15, 2019
Processing time: 118 Days and 3.9 Hours
Core Tip
Core tip: Gestational Hypertension (GHTN) can increase risk of fetal and neonatal morbidity and mortality. Many environmental, nutritional and genetic factors are related to the development of GHTN. Among them, Epidermal Growth Factor Receptor (EGFR) has been found to contribute to arterial hypertension. It is thus plausible that Single nucleotide polymorphisms (SNPs) in EGFR gene would be associated with the development of GHTN in women with GDM. This pilot study indicated that EGFR rs17337023 polymorphism may not be involved in the pathophysiology of GHTN in GDM positive females in a local population. Further large-scale studies should explore SNPs in EGFR and other genes in this regard.