KCNQ1 rs2237895 gene polymorphism increases susceptibility to type 2 diabetes mellitus in Asian populations

doi:10.4239/wjd.v15.i3.552

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Mar 15, 2024; 15(3): 552-564
Published online Mar 15, 2024. doi: 10.4239/wjd.v15.i3.552

KCNQ1 rs2237895 gene polymorphism increases susceptibility to type 2 diabetes mellitus in Asian populations

Dong-Xu Li, Li-Ping Yin, Yu-Qi Song, Nan-Nan Shao, Huan Zhu, Chen-Sen He, Jiang-Jie Sun

Dong-Xu Li, Yu-Qi Song, Huan Zhu, First Clinical Medical College, Anhui Medical University, Hefei 230032, Anhui Province, China

Li-Ping Yin, Chen-Sen He, School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei 230032, Anhui Province, China

Nan-Nan Shao, School of Clinical Medicine, Anhui Medical University, Hefei 230031, Anhui Province, China

Jiang-Jie Sun, School of Health Care Management, Anhui Medical University, Hefei 230032, Anhui Province, China

Co-first authors: Dong-Xu Li and Li-Ping Yin.

Co-corresponding authors: Chen-Sen He and Jiang-Jie Sun.

Author contributions: Li DX, Yin LP, Sun JJ, and He CS designed this study (substantial contributions to the conception); Li DX, Yin LP, Song YQ, Shao NN, and Zhu H collected data; Li DX and Yin LP extracted and analyzed data, interpretation of data for the work; Sun JJ and He CS provided guidance for statistical analysis and provided financial support. They agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy; Li DX and Yin LP wrote the manuscript; Li DX, Yin LP, Song YQ, Shao NN, Zhu H, Sun JJ and He CS reviewed the manuscript; Li DX and Yin LP contributed equally to this work as co-first authors; Sun JJ and He CS contributed equally to this work as co-corresponding authors. The reasons for designating Li DX and Yin LP as co-first authors are as follows. First, Li DX and Yin LP contributed equal effort throughout the study. The selection of these researchers as co-first authors respects their equal contributions. Second, the research was conducted as a collaborative effort, and the designation of co-first authors accurately reflects the distribution of responsibilities and burdens associated with the time and effort required to complete the research and final paper. The reasons for designating Sun JJ and He CS as co-corresponding authors are as follows. First, Sun JJ and He CS put equal effort into the entire study. Second, the designation of co-corresponding authors best reflects the need for this study to have authors from different fields, which promotes the most in-depth examination of the research topic. In summary, we believe that the designation of Li DX and Yin LP as co-first authors and Sun JJ and He CS as co-corresponding authors meets the requirements of our manuscript, which reflects the spirit of equality and cooperation in our team.

Supported by the Natural Science Foundation for the Higher Education Institutions of Anhui Province of China, No. 2023AH050561, No. 2022AH051143, No. KJ2021A0266, and No. KJ2021A1228; and School-level offline courses, No. 2021xjkc13.

Conflict-of-interest statement: The authors declare no competing interests.

PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.

Corresponding author: Jiang-Jie Sun, PhD, Professor, School of Health Care Management, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui Province, China. sunjiangjie@ahmu.edu.cn

Received: September 25, 2023
Peer-review started: September 25, 2023
First decision: December 6, 2023
Revised: December 13, 2023
Accepted: February 2, 2024
Article in press: February 2, 2024
Published online: March 15, 2024
Processing time: 172 Days and 2 Hours

ARTICLE HIGHLIGHTS

Research background

The association between the rs2237895 single nucleotide polymorphism (SNP) in the KCNQ1 gene and the prevalence of type 2 diabetes mellitus (T2DM) has been controversial in different studies.

Research motivation

The aim of this study was to investigate the association between the KCNQ1 gene rs2237895 and the prevalence of T2DM, and to provide help in establishing the pathogenesis of T2DM.

Research objectives

Demonstration of the association of the rs2237895 SNP in the KCNQ1 gene with the prevalence of T2DM. Also, to explore whether this relationship differs in different populations.

Research methods

We searched nine databases. Two authors independently screened the literature according to the established inclusion and exclusion criteria. Finally, data extraction was performed and the data were meta-analyzed.

Research results

Twelve case–control studies met our inclusion criteria. After analysis, the rs2237895 SNP in the KCNQ1 gene was associated with T2DM prevalence in Asian populations. However, this association was not significant in non-Asian populations.

Research conclusions

In Asian populations, carriers of the rs2237895 C allele of the KCNQ1 gene were highly susceptible to T2DM compared to those who did not carry the C allele. However, in non-Asian populations, the association between the rs2237895 SNP and T2DM was not significant.

Research perspectives

We should continue to search for T2DM susceptibility genes through advanced technologies (e.g., genome-wide association strategy) and gradually elucidate the pathogenesis of T2DM.