Application of urinary N-acetyl-β-D-glucosaminidase combined with serum retinol-binding protein in early detection of diabetic nephropathy

doi:10.4239/wjd.v14.i6.883

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Jun 15, 2023; 14(6): 883-891
Published online Jun 15, 2023. doi: 10.4239/wjd.v14.i6.883

Application of urinary N-acetyl-β-D-glucosaminidase combined with serum retinol-binding protein in early detection of diabetic nephropathy

Zhi-Hao Lin, Sheng-Feng Dai, Jian-Nan Zhao, Yue Jiang

Zhi-Hao Lin, Sheng-Feng Dai, Department of Endocrinology, Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang University of Traditional Chinese Medicine, Wenzhou 325000, Zhejiang Province, China

Jian-Nan Zhao, Department of Endocrinology, Yongjia Hospital of Traditional Chinese Medicine, Wenzhou 325000, Zhejiang Province, China

Yue Jiang, Department of Acupuncture, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China

Author contributions: Lin ZH and Jiang Y concepted the study, supervised the study, contributed to the investigation, the visualization of the study, and originally drafted the manuscript; Dai SF collected the data; Zhao JN contributed to the formal analysis; Dai SF and Zhao JN contributed to the methodology; Jiang Y validated the study; Lin ZH, Dai SF, Zhao JN and Jiang Y reviewed and edited the manuscript.

Institutional review board statement: The study was reviewed and approved by the Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang University of Traditional Chinese Medicine Institutional Review Board.

Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.

Conflict-of-interest statement: All authors have no conflict of interest.

Data sharing statement: No additional data are available.

Corresponding author: Yue Jiang, MD, Occupational Physician, Department of Acupuncture, The First Affiliated Hospital of Wenzhou Medical University, Shangcai Village, Nanbaixiang Street, Ouhai District, Wenzhou 325000, Zhejiang Province, China. jyygl9397@126.com

Received: March 14, 2023
Peer-review started: March 14, 2023
First decision: April 7, 2023
Revised: April 16, 2023
Accepted: April 24, 2023
Article in press: April 24, 2023
Published online: June 15, 2023
Processing time: 92 Days and 23.6 Hours

ARTICLE HIGHLIGHTS

Research background

Diabetic nephropathy (DN) is a microangiopathy of type 2 diabetes mellitus (T2DM), which can damage the kidney through various ways and mechanisms due to the nature of the disease, involving the renal interstitium and glomeruli. However, in the early stage of the disease, patients only showed kidney volume increase and glomerular hyperthyroidism, and typical symptoms that are difficult to arouse individual attention were noticed. The symptoms were only noticed when the patients developed edema and proteinuria. At this time, the disease has progressed to an irreversible stage, and the best treatment timing should be taken. Therefore, finding new clinical biochemical factors or examination methods to help early detection of clinical DN patients is particularly important to guide the development of early intervention measures and improve the prognosis of patients.

Research motivation

This study provided new targets for early diagnosis and treatment of DN.

Research objectives

This study aimed to observe the expression of serum retinol-binding protein (RBP) and urinary N-acetyl-β-D-glucosaminidase (NAG) in patients with DN.

Research methods

Total 50 T2DM patients were retrospectively reviewed and included in group A. The baseline data of 50 patients with type 2 DN during the same period were collected and included in group B. The baseline data and serum RBP and urine NAG expression were compared between the two groups to analyze their value in the early prediction of DN.

Research results

The increased expression of urinary NAG and serum RBP may be the risk factors leading to the progression of T2DM to DN.

Research conclusions

The possibility of DN can be considered in patients with urinary NAG and serum RBP overexpression by examining the expression of urinary NAG and serum RBP in patients with T2DM in clinical practice.

Research perspectives

This study showed that urine NAG combined with serum RBP had good application prospects in the early detection of DN. Future studies can further expand the research sample size and improve the diagnostic accuracy of urinary NAG combined with serum RBP.