Huang YY, Qin XK, Dai YY, Huang L, Huang GR, Qin YC, Wei X, Huang YQ. Preparation and hypoglycemic effects of chromium- and zinc-rich Acetobacter aceti. World J Diabetes 2022; 13(6): 442-453 [PMID: 35800410 DOI: 10.4239/wjd.v13.i6.442]
Corresponding Author of This Article
Xian Wei, MD, Associated Professor, Research Center for the Prevention and Treatment of Drug Resistant Microbial Infection, Youjiang Medical University for Nationalities, No. 98 ChengXiang Road, Youjiang District, Baise 533000, Guangxi Zhuang Autonomous Region, China. 27848258@qq.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Yong-Yi Huang, Xiang-Kun Qin, Yuan-Yuan Dai, Liang Huang, Gan-Rong Huang, Yan-Chun Qin, Xian Wei, Yan-Qiang Huang, Research Center for the Prevention and Treatment of Drug Resistant Microbial Infection, Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China
Author contributions: Huang YY was responsible for the experimental research; Qin XK, Dai YY, Huang L, and Huang GR consulted the literature and wrote the first draft, then corrected and improved the manuscript; Wei X and Huang YQ designed, checked, modified, and finalized the manuscript, contributed equally to this work, and agreed to serve as co-corresponding authors; All authors proofread the revised manuscript.
Supported bythe Fourth Self-funded Projects of Baise Scientific Research and Technology Development Plan, No. 20203402; and School-level Scientific Research Project of Youjiang Medical University for Nationalities, No. yy2021sk029.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Youjiang Medical University for Nationalities.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Data sharing statement: All experimental data are presented in the paper.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Corresponding author: Xian Wei, MD, Associated Professor, Research Center for the Prevention and Treatment of Drug Resistant Microbial Infection, Youjiang Medical University for Nationalities, No. 98 ChengXiang Road, Youjiang District, Baise 533000, Guangxi Zhuang Autonomous Region, China. 27848258@qq.com
Received: March 1, 2022 Peer-review started: March 1, 2022 First decision: April 17, 2022 Revised: April 25, 2022 Accepted: May 21, 2022 Article in press: May 21, 2022 Published online: June 15, 2022 Processing time: 98 Days and 16.9 Hours
ARTICLE HIGHLIGHTS
Research background
At present, there are no ideal drugs to treat diabetes. Acetobacter and other probiotics can play a role in the treatment of diabetes; however, their effect is not significant. In this study, metal compounds were used to enrich Acetobacter with chromium and zinc in an effort to enhance the hypoglycemic effect of these bacteria.
Research motivation
This research provides a theoretical basis for the application of new chromium- and zinc-rich Acetobacter aceti (A. aceti) to treat diabetes.
Research objectives
To prepare a new type of chromium- and zinc-rich A. aceti and explore its hypoglycemic effects on enhancing the application of probiotics in the treatment of diabetes.
Research methods
A. aceti was cultured in a liquid medium that contained chromium trichloride and zinc chloride.
Research results
A new type of chromium and zinc rich A. aceti was successfully prepared.
Research conclusions
Chromium- and zinc-rich A. aceti has a significantly enhanced hypoglycemic effect and can biotransform chromium and zinc to improve safety for administering these metals as a treatment.
Research perspectives
The new method described has very good application prospects.
