Letters To Editor
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World J Diabetes. May 15, 2011; 2(5): 75-76
Published online May 15, 2011. doi: 10.4239/wjd.v2.i5.75
Elevated pancreatic enzymes, IgM, soluble interleukin-2 receptor in anti-GADab(+) type 1 diabetes
Hidekatsu Yanai, Sumie Moriyama
Hidekatsu Yanai, Sumie Moriyama, Department of Internal Medicine, Kohnodai Hospital, National Center for Global Health and Medicine, Chiba 272-8516, Japan
Author contributions: Yanai H and Moriyama S contributed to the conception, writing and editing of this letter; both authors also treated the patient presented in the letter, and contributed to data collection.
Correspondence to: Hidekatsu Yanai, MD, PhD, FACP, Department of Internal Medicine, Kohnodai Hospital, National Center for Global Health and Medicine, Chiba 272-8516, Japan. dyanai@hospk.ncgm.go.jp
Telephone: +81-47-373-3501 Fax: +81-47-372-1858
Received: November 26, 2010
Revised: March 23, 2011
Accepted: March 30, 2011
Published online: May 15, 2011
Abstract

Type 1 diabetes can be classified into immune-mediated diabetes (type 1A) and idiopathic diabetes, which lacks immunological evidence for beta cell autoimmunity (type 1B). Type 1A diabetes is characterized by the presence of the anti-glutamic acid decarboxylase antibody (anti-GADab). Fulminant type 1 diabetes is classified as type 1B diabetes, and characterized by the absence of anti-GADab, flu-like symptoms, and elevated serum exocrine pancreatic enzymes. We report a type 1 diabetic patient who showed flu-like symptoms, elevated serum exocrine pancreatic enzymes, and an extremely high-titer of anti-GADab, manifesting the characteristics of both type 1A and fulminant type 1 diabetes.

Keywords: Anti-glutamic acid decarboxylase antibody; Exocrine pancreatic enzymes; Type 1 diabetes; Soluble interleukin-2 receptor