Wang SY, Sun NZ, Wu PF, Tang JY. Letter to the Editor: Unveiling the role of decapping scavenger enzyme in diabetic foot ulcers: Linking N7-methylguanosine RNA modification to impaired wound healing. World J Diabetes 2026; 17(6): 115947 [DOI: 10.4239/wjd.115947]
Corresponding Author of This Article
Nian-Zhe Sun, MD, National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Kaifu District, Changsha 410008, Hunan Province, China. sunnzh201921@sina.com
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Endocrinology & Metabolism
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letter
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Wang SY, Sun NZ, Wu PF, Tang JY. Letter to the Editor: Unveiling the role of decapping scavenger enzyme in diabetic foot ulcers: Linking N7-methylguanosine RNA modification to impaired wound healing. World J Diabetes 2026; 17(6): 115947 [DOI: 10.4239/wjd.115947]
World J Diabetes. Jun 15, 2026; 17(6): 115947 Published online Jun 15, 2026. doi: 10.4239/wjd.115947
Letter to the Editor: Unveiling the role of decapping scavenger enzyme in diabetic foot ulcers: Linking N7-methylguanosine RNA modification to impaired wound healing
Shi-Yi Wang, University Medical Center Groningen, University of Groningen, Groningen 9700 RB, Netherlands
Nian-Zhe Sun, Pan-Feng Wu, Ju-Yu Tang, National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
Co-corresponding authors: Nian-Zhe Sun and Pan-Feng Wu.
Author contributions: Wang SY wrote the first draft, developed the main ideas, and revised the manuscript; Tang JY provided the additional ideas; Sun NZ and Wu PF provided critical feedback, improved the manuscript structure, and added key examples. This letter designates Sun NZ and Wu PF as co-corresponding authors based on their equal and substantial intellectual contributions to this work. As a concise academic correspondence, its focus lies in presenting a novel perspective and a rigorous, logical argument. Sun NZ provided the foundational conceptual direction and oversaw the critical argumentation that forms the core of our response. Wu PF was instrumental in the in-depth critical review, structural refinement, and ensuring the overall precision and academic tone of the manuscript. Both authors jointly conceived the intellectual framework, participated in manuscript drafting, and iteratively revised the text to its final form. This designation accurately reflects their shared responsibility and equal intellectual leadership in developing and finalizing this scholarly communication, in accordance with established academic authorship norms.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Nian-Zhe Sun, MD, National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Kaifu District, Changsha 410008, Hunan Province, China. sunnzh201921@sina.com
Received: October 30, 2025 Revised: January 12, 2026 Accepted: February 4, 2026 Published online: June 15, 2026 Processing time: 225 Days and 5.1 Hours
Abstract
Diabetic foot ulcer (DFU), a common complication of diabetes, is often associated with non-healing wounds that can eventually lead to infection and amputation. Epitranscriptomic modifications have been shown to have an important impact on metabolic diseases. Recently, a study by Xiao et al published in World Journal of Diabetes focused on the role of the N7-methylguanosine-related decapping scavenger enzyme (DCPS) in DFU. They found that DCPS is linked to keratinocyte dysfunction in DFU and that in DFU tissue and diabetic mouse skin, DCPS is significantly down-regulated. Silencing DCPS induces cell cycle arrest and apoptosis, thereby inhibiting keratinocyte proliferation and migration. These findings suggest that impaired RNA cap turnover and mRNA decay may lead to defective wound healing in diabetes-a mechanism that is different from changes in RNA methylation alone. This study highlights DCPS as a potential biomarker and therapeutic target for treatment of diabetic wounds.
Core Tip: Reduced expression of the N7-methylguanosine decapping scavenger enzyme (DCPS) has been observed in diabetes and associated with impaired keratinocyte regeneration. DCPS may work as a useful biomarker and therapeutic target for improving wound healing in diabetes.
