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World J Diabetes. Sep 15, 2024; 15(9): 1858-1861
Published online Sep 15, 2024. doi: 10.4239/wjd.v15.i9.1858
Rapid correction of chronic hyperglycemia and bone remodeling, warning against overdoing
Dured Dardari, Beatrice Segurens
Dured Dardari, Department of Diabetology, Centre Hospitalier Sud Francilien, Corbeil Essonne 91100, France
Beatrice Segurens, Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH), Evry Courcouronnes, France
Author contributions: Dardari D and Segurens B wrote the protocol, produced the statistics, collected the data, wrote and reviewed the manuscript; Dardari D and Segurens B are the guarantors of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis; All authors approved the final version of the manuscript.
Conflict-of-interest statement: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Dured Dardari, PhD, Academic Editor, Doctor, Department of Diabetology, Centre Hospitalier Sud Francilien, No. 40 Avenue Serge Dassault, Corbeil Essonne 91100, France. dured.dardari@chsf.fr
Received: January 29, 2024
Revised: June 4, 2024
Accepted: July 2, 2024
Published online: September 15, 2024
Processing time: 210 Days and 23.2 Hours
Abstract

It is widely recognized that chronic hyperglycemia decreases bone quality, although little is known about the impact of the rapid correction of chronic hyperglycemia on the quality of bone remodeling. This spotlight article explores this correlation by focusing on the stages of bone remodeling linked to glucose levels.

Keywords: Bone remodeling; Chronic hyperglycemia; Intensive hyperglycemia treatment; Diabetes complication; Rapid correction of hyperglycemia

Core Tip: The protein osteocalcin involved in bone remodeling is affected by glucose metabolism and variation. Osteoprotegerin and receptor activator of NF-kB ligand also involved in bone modeling are equally sensitive to glucose variation. Bone remodeling is impaired when glucose levels are reduced and only not only when the blood glucose threshold is exceeded.