Li J, Li ZP, Xu SS, Wang W. Unraveling the biological link between diabetes mellitus and prostate cancer: Insights and implications. World J Diabetes 2024; 15(6): 1367-1373 [PMID: 38983816 DOI: 10.4239/wjd.v15.i6.1367]
Corresponding Author of This Article
Wei Wang, MD, Attending Doctor, Department of Interventional Oncology, Municipal Hospital Affiliated to Taizhou University, No. 381-1 Zhongshan East Road, Jiaojiang District, Taizhou 318000, Zhejiang Province, China. westernfox000@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Jun 15, 2024; 15(6): 1367-1373 Published online Jun 15, 2024. doi: 10.4239/wjd.v15.i6.1367
Unraveling the biological link between diabetes mellitus and prostate cancer: Insights and implications
Jian Li, Zhi-Peng Li, Si-Si Xu, Wei Wang
Jian Li, Wei Wang, Department of Interventional Oncology, Municipal Hospital Affiliated to Taizhou University, Taizhou 318000, Zhejiang Province, China
Zhi-Peng Li, Si-Si Xu, School of Medicine, Taizhou University, Taizhou 318000, Zhejiang Province, China
Author contributions: Li J and Li ZP contributed to the validation and writing of the original draft of this manuscript; Xu SS was involved in the formal analysis and software; Wang W participated in the conceptualization, writing, reviewing and editing of this article; all authors participated in drafting the manuscript; and all authors have read, contributed to, and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei Wang, MD, Attending Doctor, Department of Interventional Oncology, Municipal Hospital Affiliated to Taizhou University, No. 381-1 Zhongshan East Road, Jiaojiang District, Taizhou 318000, Zhejiang Province, China. westernfox000@163.com
Received: January 26, 2024 Revised: March 15, 2024 Accepted: April 18, 2024 Published online: June 15, 2024 Processing time: 137 Days and 0.9 Hours
Abstract
This article is a comprehensive study based on research on the connection between diabetes mellitus (DM) and prostate cancer (PCa). It investigates the potential role of DM as an independent risk factor for PCa, delving into the biological links, including insulin resistance and hormonal changes. The paper critically analyzes previous studies that have shown varying results and introduces mendelian randomization as a method for establishing causality. It emphasizes the importance of early DM screening and lifestyle modifications in preventing PCa, and proposes future research directions for further under-standing the DM - PCa relationship.
Core Tip: The article emphasizes diabetes mellitus (DM) as a potential independent risk factor for prostate cancer (PCa), and delves into the possible biological mechanisms related to both diseases, such as insulin resistance and hormonal changes. The document also reviews existing research, providing an in-depth analysis of the application of mendelian randomization in the context of the relationship between DM and PCa. It underscores the importance of early DM screening and lifestyle interventions in potentially preventing PCa. Furthermore, it highlights the need for future research to further elucidate this complex relationship.
