Unraveling the biological link between diabetes mellitus and prostate cancer: Insights and implications

Abstract

This article is a comprehensive study based on research on the connection between diabetes mellitus (DM) and prostate cancer (PCa). It investigates the potential role of DM as an independent risk factor for PCa, delving into the biological links, including insulin resistance and hormonal changes. The paper critically analyzes previous studies that have shown varying results and introduces mendelian randomization as a method for establishing causality. It emphasizes the importance of early DM screening and lifestyle modifications in preventing PCa, and proposes future research directions for further under-standing the DM - PCa relationship.

Keywords: Biological mechanisms; Diabetes mellitus; Mendelian randomization; Prevention prostatic cancer; Treatment

Core Tip: The article emphasizes diabetes mellitus (DM) as a potential independent risk factor for prostate cancer (PCa), and delves into the possible biological mechanisms related to both diseases, such as insulin resistance and hormonal changes. The document also reviews existing research, providing an in-depth analysis of the application of mendelian randomization in the context of the relationship between DM and PCa. It underscores the importance of early DM screening and lifestyle interventions in potentially preventing PCa. Furthermore, it highlights the need for future research to further elucidate this complex relationship.