Molecular mechanisms of noncoding RNA and epigenetic regulation in obesity with consequent diabetes mellitus development

doi:10.4239/wjd.v14.i11.1621

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 14, Issue 11

This Article

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (6689)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-1) series, Tables (1-3) series.

Item

Count

PDF

196

WORD

HTML

2468

Figures (1-1)

507

Tables (1-3)

488

Sum=3697

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

259

Download

1024

Sum=1283

Publishing Process of This Article

Item

Count

Browse

382

Download

1069

Sum=1451

Nov 15, 2023 (publication date) through Feb 25, 2026

Times Cited of This Article

Times Cited (8)

Journal Information of This Article

Publication Name

World Journal of Diabetes

ISSN

1948-9358

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Minireviews

World J Diabetes. Nov 15, 2023; 14(11): 1621-1631
Published online Nov 15, 2023. doi: 10.4239/wjd.v14.i11.1621

Molecular mechanisms of noncoding RNA and epigenetic regulation in obesity with consequent diabetes mellitus development

Yi-Chen Guo, Hao-Di Cao, Xiao-Fen Lian, Pei-Xian Wu, Fan Zhang, Hua Zhang, Dong-Hui Lu

Yi-Chen Guo, Xiao-Fen Lian, Pei-Xian Wu, Fan Zhang, Dong-Hui Lu, Department of Endo-crinology, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China

Yi-Chen Guo, Hao-Di Cao, Hua Zhang, Department of Endocrinology, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, Guangdong Province, China

Author contributions: Guo YC and Cao HD contributed equally to this work; Guo YC, Cao HD, Lian XF, Wu PX, Zhang F, Zhang H, and Lu DH designed the research; Cao HD and Lian XF contributed analytic tools and specifically visualization; Guo YC analyzed the data and wrote the manuscript; Wu PX, Zhang F, Zhang H, and Lu DH edited and reviewed the manuscript; and all authors have read and approve the final manuscript.

Supported by the Shenzhen Science and Technology Innovation Committee Projects, No. JCYJ20170816105416349; Shenzhen High-level Hospital Construction Fund; and Shenzhen Key Medical Discipline Construction Fund, No. SZXK010.

Conflict-of-interest statement: The authors have no conflicts of interest to declare.

Corresponding author: Dong-Hui Lu, MD, Chief Physician, Department of Endocrinology, Peking University Shenzhen Hospital, No. 1120 Lianhua Road, Futian District, Shenzhen 518036, Guangdong Province, China. ludongh@sina.com

Received: July 12, 2023
Peer-review started: July 12, 2023
First decision: August 10, 2023
Revised: August 26, 2023
Accepted: September 27, 2023
Article in press: September 27, 2023
Published online: November 15, 2023
Processing time: 124 Days and 18.6 Hours

Abstract

Diabetes mellitus (DM) and obesity have become two of the most prevalent and challenging diseases worldwide, with increasing incidence and serious complications. Recent studies have shown that noncoding RNA (ncRNA) and epigenetic regulation play crucial roles in the pathogenesis of DM complicated by obesity. Identification of the involvement of ncRNA and epigenetic regulation in the pathogenesis of diabetes with obesity has opened new avenues of investigation. Targeting these mechanisms with small molecules or RNA-based therapies may provide a more precise and effective approach to diabetes treatment than traditional therapies. In this review, we discuss the molecular mechanisms of ncRNA and epigenetic regulation and their potential therapeutic targets, and the research prospects for DM complicated with obesity.

Keywords: Diabetes mellitus; Obesity; Noncoding RNA; Epigenetic regulation; Insulin resistance

Core Tip: Non-coding RNA (ncRNA) and epigenetic regulation play crucial roles in the pathogenesis of diabetes mellitus complicated by obesity. Identification of the involvement of ncRNA and epigenetic regulation in the pathogenesis of diabetes with obesity has opened new avenues. Targeting these mechanisms with small molecules or RNA-based therapies may provide a more precise and effective approach to diabetes treatment than traditional therapies.