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Li Y, Zheng G, Wen B, Zhang X. Altered spontaneous brain activity in children with deprivation amblyopia: a resting-state functional magnetic resonance imaging study. Eur J Med Res 2025; 30:31. [PMID: 39810202 PMCID: PMC11734425 DOI: 10.1186/s40001-025-02275-2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/21/2024] [Accepted: 01/04/2025] [Indexed: 01/16/2025] Open
Abstract
BACKGROUND To investigate the alterations in spontaneous brain activity and the similarities and differences between monocular deprivation amblyopia and binocular deprivation amblyopia. METHODS Twenty children with binocular deprivation amblyopia, 26 children with monocular deprivation amblyopia and 20 healthy controls underwent resting-state functional magnetic resonance imaging. The evaluation of altered spontaneous brain activity was conducted using fractional amplitude of low-frequency fluctuations (fALFF). One-way analysis of variance was employed to analyze fALFF values among the three groups. Additionally, the relationship between fALFF values and best corrected visual acuity (BCVA) was analyzed via correlation analysis. RESULTS Compared to healthy controls, children with binocular deprivation amblyopia presented increased fALFF values in the left medial superior frontal gyrus, left middle frontal gyrus, left anterior cingulate cortex, left postcentral gyrus and bilateral precentral gyrus, and decreased fALFF values in the right fusiform gyrus. Compared to healthy controls, children with monocular deprivation amblyopia presented increased fALFF values in the right lingual gyrus, right superior frontal gyrus, right middle frontal gyrus, left superior temporal gyrus, triangular part of the left inferior frontal gyrus and bilateral middle temporal gyrus, and decreased fALFF values in the right precuneus. Compared with monocular deprivation amblyopia, fALFF values of binocular deprivation amblyopia were decreased in the triangular part of the left inferior frontal gyrus, right lingual gyrus and right cuneus, and increased in the left precentral gyrus and left postcentral gyrus. No significant correlations were found between the fALFF values of identified regions and the BCVA of amblyopic eyes for either type of amblyopia. CONCLUSIONS Children with deprivation amblyopia presented alterations in spontaneous activity in multiple brain regions, and these alterations differed between monocular amblyopia and binocular amblyopia. These abnormal spontaneous activities may reflect dysfunctions and compensation related to amblyopia.
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Affiliation(s)
- Yadong Li
- Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
| | - Guangying Zheng
- Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
| | - Baohong Wen
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
| | - Xiaopan Zhang
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
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Wang G, Liu L. Amblyopia: progress and promise of functional magnetic resonance imaging. Graefes Arch Clin Exp Ophthalmol 2022; 261:1229-1246. [PMID: 36282454 DOI: 10.1007/s00417-022-05826-z] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/28/2021] [Revised: 08/14/2022] [Accepted: 09/02/2022] [Indexed: 11/28/2022] Open
Abstract
Amblyopia is a neurodevelopmental disorder characterized by functional deficits in the visual cortex. Functional magnetic resonance imaging (fMRI) is the most commonly used neuroimaging technique for investigating amblyopia. Herein, we systematically searched a PubMed database from inception to December 2021 to highlight the current progress and promises about fMRI technology in amblyopia; amblyopia's neural mechanism, the comparison of different types of amblyopia, and the evaluation of the therapeutic effect were explored. Relevant articles published in English and appropriate cross-references were considered for inclusion, including basic studies, imaging techniques, clinical diagnostic and therapeutic studies, case series, and reviews.
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Affiliation(s)
- Guiqu Wang
- Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, 610041, China
| | - Longqian Liu
- Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, 610041, China.
- Department of Optometry and Visual Science, West China Hospital, Sichuan University, Chengdu, 610041, China.
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陈 霞, 廖 孟, 蒋 苹, 刘 陇, 龚 启. [Abnormal spontaneous brain functional activity in adult patients with amblyopia: a resting-state functional magnetic resonance imaging study]. SHENG WU YI XUE GONG CHENG XUE ZA ZHI = JOURNAL OF BIOMEDICAL ENGINEERING = SHENGWU YIXUE GONGCHENGXUE ZAZHI 2022; 39:759-766. [PMID: 36008340 PMCID: PMC10957354 DOI: 10.7507/1001-5515.202203072] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Subscribe] [Scholar Register] [Received: 03/24/2022] [Revised: 06/19/2022] [Indexed: 06/15/2023]
Abstract
Amblyopia is a visual development deficit caused by abnormal visual experience in early life, mainly manifesting as defected visual acuity and binocular visual impairment, which is considered to reflect abnormal development of the brain rather than organic lesions of the eye. Previous studies have reported abnormal spontaneous brain activity in patients with amblyopia. However, the location of abnormal spontaneous activity in patients with amblyopia and the association between abnormal brain function activity and clinical deficits remain unclear. The purpose of this study is to analyze spontaneous brain functional activity abnormalities in patients with amblyopia and their associations with clinical defects using resting-state functional magnetic resonance imaging (fMRI) data. In this study, 31 patients with amblyopia and 31 healthy controls were enrolled for resting-state fMRI scanning. The results showed that spontaneous activity in the right angular gyrus, left posterior cerebellum, and left cingulate gyrus were significantly lower in patients with amblyopia than in controls, and spontaneous activity in the right middle temporal gyrus was significantly higher in patients with amblyopia. In addition, the spontaneous activity of the left cerebellum in patients with amblyopia was negatively associated with the best-corrected visual acuity of the amblyopic eye, and the spontaneous activity of the right middle temporal gyrus was positively associated with the stereoacuity. This study found that adult patients with amblyopia showed abnormal spontaneous activity in the angular gyrus, cerebellum, middle temporal gyrus, and cingulate gyrus. Furthermore, the functional abnormalities in the cerebellum and middle temporal gyrus may be associated with visual acuity defects and stereopsis deficiency in patients with amblyopia. These findings help explain the neural mechanism of amblyopia, thus promoting the improvement of the treatment strategy for amblyopia.
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Affiliation(s)
- 霞 陈
- 四川大学华西医院 眼科（成都 610041）Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu 610041, P. R. China
- 四川大学 华西临床医学院 眼视光学系（成都 610041）Department of Optometry and Visual Science, West China School of Medicine, Sichuan University, Chengdu 610041, P. R. China
| | - 孟 廖
- 四川大学华西医院 眼科（成都 610041）Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu 610041, P. R. China
- 四川大学 华西临床医学院 眼视光学系（成都 610041）Department of Optometry and Visual Science, West China School of Medicine, Sichuan University, Chengdu 610041, P. R. China
| | - 苹 蒋
- 四川大学华西医院 眼科（成都 610041）Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu 610041, P. R. China
- 四川大学 华西临床医学院 眼视光学系（成都 610041）Department of Optometry and Visual Science, West China School of Medicine, Sichuan University, Chengdu 610041, P. R. China
| | - 陇黔 刘
- 四川大学华西医院 眼科（成都 610041）Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu 610041, P. R. China
- 四川大学 华西临床医学院 眼视光学系（成都 610041）Department of Optometry and Visual Science, West China School of Medicine, Sichuan University, Chengdu 610041, P. R. China
| | - 启勇 龚
- 四川大学华西医院 眼科（成都 610041）Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu 610041, P. R. China
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Dai P, Zhou X, Ou Y, Xiong T, Zhang J, Chen Z, Zou B, Wei X, Wu Y, Xiao M. Altered Effective Connectivity of Children and Young Adults With Unilateral Amblyopia: A Resting-State Functional Magnetic Resonance Imaging Study. Front Neurosci 2021; 15:657576. [PMID: 34295218 PMCID: PMC8290343 DOI: 10.3389/fnins.2021.657576] [Citation(s) in RCA: 10] [Impact Index Per Article: 2.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/23/2021] [Accepted: 05/21/2021] [Indexed: 01/02/2023] Open
Abstract
The altered functional connectivity (FC) in amblyopia has been investigated by many studies, but the specific causality of brain connectivity needs to be explored further to understand the brain activity of amblyopia. We investigated whether the effective connectivity (EC) of children and young adults with amblyopia was altered. The subjects included 16 children and young adults with left eye amblyopia and 17 healthy controls (HCs). The abnormalities between the left/right primary visual cortex (PVC) and the other brain regions were investigated in a voxel-wise manner using the Granger causality analysis (GCA). According to the EC results in the HCs and the distribution of visual pathways, 12 regions of interest (ROIs) were selected to construct an EC network. The alteration of the EC network of the children and young adults with amblyopia was analyzed. In the voxel-wise manner analysis, amblyopia showed significantly decreased EC between the left/right of the PVC and the left middle frontal gyrus/left inferior frontal gyrus compared with the HCs. In the EC network analysis, compared with the HCs, amblyopia showed significantly decreased EC from the left calcarine fissure, posterior cingulate gyrus, left lingual gyrus, right lingual gyrus, and right fusiform gyrus to the right calcarine fissure. Amblyopia also showed significantly decreased EC from the right inferior frontal gyrus and right lingual gyrus to the left superior temporal gyrus compared with the HCs in the EC network analysis. The results may indicate that amblyopia altered the visual feedforward and feedback pathway, and amblyopia may have a greater relevance with the feedback pathway than the feedforward pathway. Amblyopia may also correlate with the feedforward of the third visual pathway.
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Affiliation(s)
- Peishan Dai
- School of Computer Science and Engineering, Central South University, Changsha, China.,Hunan Engineering Research Center of Machine Vision and Intelligent Medicine, Central South University, Changsha, China
| | - Xiaoyan Zhou
- School of Computer Science and Engineering, Central South University, Changsha, China.,Hunan Engineering Research Center of Machine Vision and Intelligent Medicine, Central South University, Changsha, China
| | - Yilin Ou
- School of Computer Science and Engineering, Central South University, Changsha, China.,Hunan Engineering Research Center of Machine Vision and Intelligent Medicine, Central South University, Changsha, China
| | - Tong Xiong
- School of Computer Science and Engineering, Central South University, Changsha, China.,Hunan Engineering Research Center of Machine Vision and Intelligent Medicine, Central South University, Changsha, China
| | - Jinlong Zhang
- School of Computer Science and Engineering, Central South University, Changsha, China.,Hunan Engineering Research Center of Machine Vision and Intelligent Medicine, Central South University, Changsha, China
| | - Zailiang Chen
- School of Computer Science and Engineering, Central South University, Changsha, China.,Hunan Engineering Research Center of Machine Vision and Intelligent Medicine, Central South University, Changsha, China
| | - Beiji Zou
- School of Computer Science and Engineering, Central South University, Changsha, China.,Hunan Engineering Research Center of Machine Vision and Intelligent Medicine, Central South University, Changsha, China
| | - Xin Wei
- Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, China.,Hunan Clinical Research Center of Ophthalmic Disease, Changsha, China
| | - Ying Wu
- Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, China.,Hunan Clinical Research Center of Ophthalmic Disease, Changsha, China
| | - Manyi Xiao
- Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, China.,Hunan Clinical Research Center of Ophthalmic Disease, Changsha, China
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Guo GY, Zhang LJ, Li B, Liang RB, Ge QM, Shu HY, Li QY, Pan YC, Pei CG, Shao Y. Altered spontaneous brain activity in patients with diabetic optic neuropathy: A resting-state functional magnetic resonance imaging study using regional homogeneity. World J Diabetes 2021; 12:278-291. [PMID: 33758647 PMCID: PMC7958477 DOI: 10.4239/wjd.v12.i3.278] [Citation(s) in RCA: 8] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/20/2020] [Revised: 12/30/2020] [Accepted: 02/12/2021] [Indexed: 02/06/2023] Open
Abstract
BACKGROUND Diabetes is a common chronic disease. Given the increasing incidence of diabetes, more individuals are affected by diabetic optic neuropathy (DON), which results in decreased vision. Whether DON leads to abnormalities of other visual systems, including the eye, the visual cortex, and other brain regions, remains unknown.
AIM To investigate the local characteristics of spontaneous brain activity using regional homogeneity (ReHo) in patients with DON.
METHODS We matched 22 patients with DON with 22 healthy controls (HCs). All subjects underwent resting-state functional magnetic resonance imaging. The ReHo technique was used to record spontaneous changes in brain activity. Receiver operating characteristic (ROC) curves were applied to differentiate between ReHo values for patients with DON and HCs. We also assessed the correlation between Hospital Anxiety and Depression Scale scores and ReHo values in DON patients using Pearson correlation analysis.
RESULTS ReHo values of the right middle frontal gyrus (RMFG), left anterior cingulate (LAC), and superior frontal gyrus (SFG)/left frontal superior orbital gyrus (LFSO) were significantly lower in DON patients compared to HCs. Among these, the greatest difference was observed in the RMFG. The result of the ROC curves suggest that ReHo values in altered brain regions may help diagnose DON, and the RMFG and LAC ReHo values are more clinically relevant than SFG/LFSO. We also found that anxiety and depression scores of the DON group were extremely negatively correlated with the LAC ReHo values (r = -0.9336, P < 0.0001 and r = -0.8453,P < 0.0001, respectively).
CONCLUSION Three different brain regions show ReHo changes in DON patients, and these changes could serve as diagnostic and/or prognostic biomarkers to further guide the prevention and treatment of DON patients.
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Affiliation(s)
- Gui-Ying Guo
- Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
| | - Li-Juan Zhang
- Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
| | - Biao Li
- Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
| | - Rong-Bin Liang
- Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
| | - Qian-Min Ge
- Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
| | - Hui-Ye Shu
- Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
| | - Qiu-Yu Li
- Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
| | - Yi-Cong Pan
- Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
| | - Chong-Gang Pei
- Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
| | - Yi Shao
- Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
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Tong Y, Huang X, Qi CX, Shen Y. Disrupted Neural Activity in Individuals With Iridocyclitis Using Regional Homogeneity: A Resting-State Functional Magnetic Resonance Imaging Study. Front Neurol 2021; 12:609929. [PMID: 33643195 PMCID: PMC7907498 DOI: 10.3389/fneur.2021.609929] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/24/2020] [Accepted: 01/11/2021] [Indexed: 12/19/2022] Open
Abstract
Objective: This study used the regional homogeneity (ReHo) technique to explore whether spontaneous brain activity is altered in patients with iridocyclitis. Methods: Twenty-six patients with iridocyclitis (14 men and 12 women) and 26 healthy volunteers (15 men and 11 women) matched for sex and age were enrolled in this study. The ReHo technique was used to comprehensively assess changes in whole-brain synchronous neuronal activity. The diagnostic ability of the ReHo method was evaluated by means of receive operating characteristic (ROC) curve analysis. Moreover, associations of average ReHo values in different brain areas and clinical characteristics were analyzed using correlation analysis. Result: Compared with healthy volunteers, reduced ReHo values were observed in patients with iridocyclitis in the following brain regions: the right inferior occipital gyrus, bilateral calcarine, right middle temporal gyrus, right postcentral gyrus, left superior occipital gyrus, and left precuneus. In contrast, ReHo values were significantly enhanced in the right cerebellum, left putamen, left supplementary motor area, and left inferior frontal gyrus in patients with iridocyclitis, compared with healthy volunteers (false discovery rate correction, P < 0.05). Conclusion: Patients with iridocyclitis exhibited disturbed synchronous neural activities in specific brain areas, including the visual, motor, and somatosensory regions, as well as the default mode network. These findings offer a novel image-guided research strategy that might aid in exploration of neuropathological or compensatory mechanisms in patients with iridocyclitis.
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Affiliation(s)
- Yan Tong
- Eye Center, Renmin Hospital of Wuhan University, Wuhan, China
| | - Xin Huang
- Department of Ophthalmology, Jiangxi Provincial People's Hospital, Nanchang, China
| | - Chen-Xing Qi
- Eye Center, Renmin Hospital of Wuhan University, Wuhan, China
| | - Yin Shen
- Eye Center, Renmin Hospital of Wuhan University, Wuhan, China.,Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China
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