Reference Citation Analysis: Find an Article, Find a Category, Find a Journal, Find a Scholar

For: Bonnefont-Rousselot D. Glucose and reactive oxygen species. Curr Opin Clin Nutr Metab Care 2002;5:561-8. [PMID: 12172481 DOI: 10.1097/00075197-200209000-00016] [Citation(s) in RCA: 308] [Impact Index Per Article: 13.4] [Reference Citation Analysis] [What about the content of this article? (0)] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 12/11/2022]

For:	Bonnefont-Rousselot D. Glucose and reactive oxygen species. Curr Opin Clin Nutr Metab Care 2002;5:561-8. [PMID: 12172481 DOI: 10.1097/00075197-200209000-00016] [Citation(s) in RCA: 308] [Impact Index Per Article: 13.4] [Reference Citation Analysis] [What about the content of this article? (0)] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 12/11/2022]

Number

Cited by Other Article(s)

Huang X, He YX, Wan S. Genetic mechanisms of hemispheric functional connectivity in diabetic retinopathy: a joint neuroimaging and transcriptomic study. Front Cell Dev Biol 2025;13:1590627. [PMID: 40406416 PMCID: PMC12096415 DOI: 10.3389/fcell.2025.1590627] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/10/2025] [Accepted: 04/22/2025] [Indexed: 05/26/2025] Open

Abstract

Background

DR represents a major cause of global vision loss; however, the genetic basis of functional homotopy,a critical neurobiological metric reflecting interhemispheric functional synchronization, remains largely unexplored. Emerging evidence suggests that DR patients exhibiting aberrant VMHC may potentially associate with distinct transcriptional profiles. These findings could provide novel mechanistic insights into the neuropathological substrates underlying DR-related visual and cognitive dysfunction.

Methods

Resting-state fMRI data from 46 DR patients and 43 HCs were analyzed to compute VMHC for assessing interhemispheric functional connectivity. Spatial transcriptomic-neuroimaging associations were examined using AHBA, revealing genes significantly correlated with VMHC alterations. Subsequent analyses included functional enrichment assessment and PPI network construction.

Results

DR patients demonstrated significantly lower VMHC in bilateral LING, PoCG, and PreCG versus controls, indicating impaired interhemispheric connectivity in visual-sensorimotor networks. VMHC variations spatially correlated with 4,000 genes (2,000 positive/negative each), enriched in transcriptional regulation, mitochondrial function, synaptic activity (BP/CC/MF), and lipid metabolism/N-glycan biosynthesis (KEGG). PPI network identified hub genes (ACTB/MRPL9/MRPS6,positive; H4C6/NDUFAB1/H3C12,negative) regulating mitochondrial dynamics, cytoskeleton, and epigenetics.

Conclusion

This study represents the first integration of fMRI and transcriptomics to elucidate the genetic determinants underlying VMHC disruption in DR. The findings demonstrate that impaired interhemispheric connectivity in DR involves complex interactions among genes regulating neurovascular, metabolic, and neurodegenerative pathways. These results significantly advance the understanding of neurological manifestations in DR and identify potential therapeutic targets for clinical intervention.

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Kopera M, Adamkiewicz M, Pieniazek A. Effect of Glyoxal on Plasma Membrane and Cytosolic Proteins of Erythrocytes. Int J Mol Sci 2025;26:4328. [PMID: 40362565 PMCID: PMC12072774 DOI: 10.3390/ijms26094328] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/25/2025] [Revised: 04/28/2025] [Accepted: 04/29/2025] [Indexed: 05/15/2025] Open

Cominelli G, Sulas F, Pinto D, Rinaldi F, Favero G, Rezzani R. Neuro-Nutritional Approach to Neuropathic Pain Management: A Critical Review. Nutrients 2025;17:1502. [PMID: 40362812 PMCID: PMC12073121 DOI: 10.3390/nu17091502] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/04/2025] [Revised: 04/15/2025] [Accepted: 04/25/2025] [Indexed: 05/15/2025] Open

Asmare DS, Abebe TA, Miskir M, Ashenef B, Adugna A, Muche Y, Melkamu A, Jemal M, Getinet M, Mengistu EF, Amare GA, Belew H, Tegegne BA, Baylie T, Haimanot AB. Magnitude and determinants of isolated systolic hypertension among type 2 diabetes patients in selected referral hospitals in Amhara Region, Ethiopia. Sci Rep 2025;15:12221. [PMID: 40211033 PMCID: PMC11985936 DOI: 10.1038/s41598-025-97578-z] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/02/2024] [Accepted: 04/07/2025] [Indexed: 04/12/2025] Open

Abstract

Patients with diabetes had significant vascular resistance, which was explained by vascular remodeling and an increase in fluid volume as a result of hyperglycemia. Insulin resistance in type 2 diabetes impairs lipid catabolism, and obesity raises the risk of isolated systolic hypertension. However, in Ethiopia minimal study has been conducted to address the specific relationship between isolated systolic hypertension and type 2 diabetes. Therefore, this study aims to determine the magnitude and determinants of isolated systolic hypertension among type 2 diabetes patients in selected referral hospitals of Amhara region, Ethiopia. A multicenter institution-based cross-sectional study was conducted from September 1 and December 30, 2023. Referral hospitals were chosen using simple random sampling. Additionally, participants in the study were chosen from the designated referral hospitals using systematic sampling approaches. To collect clinical and sociodemographic data, an interviewer-administered questionnaire was utilized. Epi-data version-4.6 and Stata-14 were used for data entry and statistical analysis, respectively. The descriptive statistics were presented with tables and graphs. A binary logistic regression model was fitted to identify associated factors of isolated systolic hypertension. In the final model, statistical significance was decided at p ≤ 0.05, and the strength of association was indicated using an adjusted odds ratio with 95% CI. The analysis included 258 participants, and the prevalence of isolated systolic hypertension was found to be 21.3% (95% CI 18-27.1%). Older age (AOR = 4.64, 95%CI 1.31,16.36), fasting blood sugar of ≥ 130 mg/dl (AOR = 2.32, 95% CI; 1.04, 5.19), and BMI > 25 Kg/m2 (AOR = 2.75, 95% CI (1.33, 5.68)) were statistically significant factors of isolated systolic hypertension. The prevalence of isolated systolic hypertension (ISH) in this study was high, affecting large population of Type 2 Diabetes Mellitus (T2DM) patients. Older age, high body mass index (BMI), and elevated fasting blood sugar levels were identified as key determinants of ISH. The study emphasizes the need for regular monitoring and management of blood pressure in T2DM patients, particularly those who are older, and have higher BMI.

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Affiliation(s)

Deresse Sinamaw Asmare Department of Biomedical Science, School of Medicine, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Tadegew Adane Abebe Department of Biomedical Science, School of Medicine, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia
Mezgebu Miskir Department of Surgery, School of Medicine, College of Medicine and Health Science, Debre Markos University, Debre Markos, Ethiopia
Baye Ashenef Department of Biomedical Science, School of Medicine, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia
Adane Adugna Medical Laboratory Science, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia
Yalew Muche Medical Laboratory Science, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia
Abateneh Melkamu Medical Laboratory Science, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia
Mohammed Jemal Department of Biomedical Science, School of Medicine, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia
Mamaru Getinet Department of Biomedical Science, School of Medicine, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia
Enyew Fenta Mengistu Department of Biomedical Science, School of Medicine, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia
Gashaw Azanaw Amare Medical Laboratory Science, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia
Habtamu Belew Medical Laboratory Science, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia
Bantayehu Addis Tegegne Department of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia
Temesgen Baylie Department of Biomedical Science, School of Medicine, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia
Aysheshim Belaineh Haimanot Department of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia

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Izadi H. Endocrine and enzymatic shifts during insect diapause: a review of regulatory mechanisms. Front Physiol 2025;16:1544198. [PMID: 40161974 PMCID: PMC11949959 DOI: 10.3389/fphys.2025.1544198] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/12/2024] [Accepted: 02/24/2025] [Indexed: 04/02/2025] Open

Abstract

Insect diapause is a vital survival strategy that enables insects to enter a state of suspended development, allowing them to withstand unfavorable environmental conditions. During diapause, insects significantly lower their metabolic rate and build up energy reserves, which they gradually utilize throughout this period. The regulation of diapause involves a complex interaction of hormones and enzymes. Juvenile hormones (JHs) affect adults and larvae differently; in adults, the absence of JH typically triggers diapause, while in larvae, the presence of JH encourages this state. Ecdysteroids, which regulate molting and metamorphosis, are carefully controlled to prevent premature development. Reduced signaling of insulin-like peptides enhances stress resistance and promotes energy storage. Several enzymes play crucial roles in the metabolic adjustments necessary for diapause. These adjustments include the degradation of JH, the ecdysteroidogenic pathway, and the metabolism of fatty acids, glycogen, cryoprotectants, and stress responses. Understanding diapause's molecular and biochemical mechanisms is essential for fundamental entomological research and practical applications. Despite recent advances, many aspects of diapause regulation, especially the interactions among hormonal pathways and the role of enzymes, remain poorly understood. This review analyzes approximately 250 papers to consolidate current knowledge on the enzymatic and hormonal regulation of diapause. It offers a comprehensive overview of key processes based on recent studies and suggests future research directions to fill gaps in our understanding of this significant biological phenomenon. The review also lays the groundwork for enhancing pest control strategies and ecological conservation by deepening our understanding of diapause mechanisms.

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Caturano A, Rocco M, Tagliaferri G, Piacevole A, Nilo D, Di Lorenzo G, Iadicicco I, Donnarumma M, Galiero R, Acierno C, Sardu C, Russo V, Vetrano E, Conte C, Marfella R, Rinaldi L, Sasso FC. Oxidative Stress and Cardiovascular Complications in Type 2 Diabetes: From Pathophysiology to Lifestyle Modifications. Antioxidants (Basel) 2025;14:72. [PMID: 39857406 PMCID: PMC11759781 DOI: 10.3390/antiox14010072] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/11/2024] [Revised: 12/30/2024] [Accepted: 01/08/2025] [Indexed: 01/27/2025] Open

Affiliation(s)

Alfredo Caturano Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy; (A.C.); (M.R.); (G.T.); (A.P.); (D.N.); (G.D.L.); (I.I.); (M.D.); (R.G.); (C.S.); (E.V.); (R.M.) Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, 00166 Rome, Italy;
Maria Rocco Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy; (A.C.); (M.R.); (G.T.); (A.P.); (D.N.); (G.D.L.); (I.I.); (M.D.); (R.G.); (C.S.); (E.V.); (R.M.)
Giuseppina Tagliaferri Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy; (A.C.); (M.R.); (G.T.); (A.P.); (D.N.); (G.D.L.); (I.I.); (M.D.); (R.G.); (C.S.); (E.V.); (R.M.)
Alessia Piacevole Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy; (A.C.); (M.R.); (G.T.); (A.P.); (D.N.); (G.D.L.); (I.I.); (M.D.); (R.G.); (C.S.); (E.V.); (R.M.)
Davide Nilo Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy; (A.C.); (M.R.); (G.T.); (A.P.); (D.N.); (G.D.L.); (I.I.); (M.D.); (R.G.); (C.S.); (E.V.); (R.M.)
Giovanni Di Lorenzo Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy; (A.C.); (M.R.); (G.T.); (A.P.); (D.N.); (G.D.L.); (I.I.); (M.D.); (R.G.); (C.S.); (E.V.); (R.M.)
Ilaria Iadicicco Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy; (A.C.); (M.R.); (G.T.); (A.P.); (D.N.); (G.D.L.); (I.I.); (M.D.); (R.G.); (C.S.); (E.V.); (R.M.)
Mariarosaria Donnarumma Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy; (A.C.); (M.R.); (G.T.); (A.P.); (D.N.); (G.D.L.); (I.I.); (M.D.); (R.G.); (C.S.); (E.V.); (R.M.)
Raffaele Galiero Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy; (A.C.); (M.R.); (G.T.); (A.P.); (D.N.); (G.D.L.); (I.I.); (M.D.); (R.G.); (C.S.); (E.V.); (R.M.)
Carlo Acierno Azienda Ospedaliera Regionale San Carlo, 85100 Potenza, Italy;
Celestino Sardu Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy; (A.C.); (M.R.); (G.T.); (A.P.); (D.N.); (G.D.L.); (I.I.); (M.D.); (R.G.); (C.S.); (E.V.); (R.M.)
Vincenzo Russo Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA; Division of Cardiology, Department of Medical Translational Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy
Erica Vetrano Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy; (A.C.); (M.R.); (G.T.); (A.P.); (D.N.); (G.D.L.); (I.I.); (M.D.); (R.G.); (C.S.); (E.V.); (R.M.)
Caterina Conte Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, 00166 Rome, Italy; Department of Endocrinology, Nutrition and Metabolic Diseases, IRCCS MultiMedica, 20099 Milan, Italy
Raffaele Marfella Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy; (A.C.); (M.R.); (G.T.); (A.P.); (D.N.); (G.D.L.); (I.I.); (M.D.); (R.G.); (C.S.); (E.V.); (R.M.)
Luca Rinaldi Department of Medicine and Health Sciences “Vincenzo Tiberio”, Università degli Studi del Molise, 86100 Campobasso, Italy
Ferdinando Carlo Sasso Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy; (A.C.); (M.R.); (G.T.); (A.P.); (D.N.); (G.D.L.); (I.I.); (M.D.); (R.G.); (C.S.); (E.V.); (R.M.)

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Vujosevic S, Lupidi M, Donati S, Astarita C, Gallinaro V, Pilotto E. Role of inflammation in diabetic macular edema and neovascular age-related macular degeneration. Surv Ophthalmol 2024;69:870-881. [PMID: 39029747 DOI: 10.1016/j.survophthal.2024.07.006] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/07/2023] [Revised: 07/09/2024] [Accepted: 07/15/2024] [Indexed: 07/21/2024]

Wang G, Zhang Y, Qiao J, El-Seedi HR, Kong L, Zhang H. Inhibitory Effects of Aqueous Ethanol Extracts of Poplar-Type Propolis on Advanced Glycation End Products and Protein Oxidation. Foods 2024;13:3022. [PMID: 39410058 PMCID: PMC11476351 DOI: 10.3390/foods13193022] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/15/2024] [Revised: 09/11/2024] [Accepted: 09/14/2024] [Indexed: 10/20/2024] Open

Coden KM, Nguyen DKK, Moorhead R, Stix-Brunell BE, Baker JN, Parker KJ, Garner JP. Making bloodwork work: the impact of sample collection, processing, and storage on plasma glutathione measurement, and implications for translation. Transl Psychiatry 2024;14:385. [PMID: 39313523 PMCID: PMC11420238 DOI: 10.1038/s41398-024-03086-5] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/06/2023] [Revised: 08/28/2024] [Accepted: 09/02/2024] [Indexed: 09/25/2024] Open

Abstract

Psychiatry has traditionally focused on the study of neurons and neurotransmitter physiology in the pathophysiology and treatment of psychiatric disorders. A growing literature highlights REDOX imbalance (a state in which demand for antioxidants surpasses their bioavailability) as a common pathophysiology for a diverse array of brain conditions (e.g., trichotillomania, schizophrenia, autism, Parkinson's disease). REDOX imbalance is typically measured via plasma glutathione, as glutathione is critical to the adaptive antioxidant response in the brain. Accordingly, glutathione, its precursors, and/or metabolites serve as biomarkers of disease risk, therapeutic targets, and measures of treatment response. However, as with any emerging field, there are currently several different methods for collection, processing, storage, and calculation of summary measures of plasma glutathione metabolism, within and between preclinical and clinical research. The lack of evidence-based best-practice methodology hampers reproducibility (preclinical or clinical), and translation (between preclinical and clinical work). To address this methodological need, here we used a repeated measures within-subject design to investigate how sample preparation (type of anticoagulant used during blood collection, deproteinization status, and storage temperature) affects plasma glutathione levels. Accordingly, we collected whole blood from mice (N = 13), and then, using a commercially available kit, quantified glutathione in plasma stored in four different ways. Presuming that these preparation conditions and post-processing calculations are unimportant, we would expect to see no difference in glutathione levels and summary measures from the same sample. However, we found each of these variables to significantly alter quantified glutathione levels. Accordingly, we propose a vital, gold-standard methodology for both sample collection, processing, and storage of plasma used for glutathione quantification and for summary calculations of glutathione that can be used preclinically and clinically, thus yielding more streamlined translation.

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Lei S, Liu C, Zheng TX, Fu W, Huang MZ. The relationship of redox signaling with the risk for atherosclerosis. Front Pharmacol 2024;15:1430293. [PMID: 39148537 PMCID: PMC11324460 DOI: 10.3389/fphar.2024.1430293] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/09/2024] [Accepted: 07/09/2024] [Indexed: 08/17/2024] Open

Ahmadi M, Hadjzadeh MAR, Rajaei Z. Effects of Berberis vulgaris fruit extract on oxidative stress status in the kidney and liver of diabetic rats. JOURNAL OF COMPLEMENTARY & INTEGRATIVE MEDICINE 2024;21:191-196. [PMID: 38282343 DOI: 10.1515/jcim-2023-0163] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 10/15/2023] [Accepted: 01/07/2024] [Indexed: 01/30/2024]

Tully CA, Alesi S, McPherson NO, Sharkey DJ, Teong XT, Tay CT, Silva TR, Puglisi C, Barsby JP, Moran LJ, Grieger JA, Mousa A. Assessing the influence of preconception diet on male fertility: a systematic scoping review. Hum Reprod Update 2024;30:243-261. [PMID: 38237150 PMCID: PMC11063564 DOI: 10.1093/humupd/dmad035] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/14/2023] [Revised: 11/21/2023] [Indexed: 05/03/2024] Open

Abstract

BACKGROUND

The last decade has seen increased research on the relationship between diet and male fertility, but there are no clearly defined nutritional recommendations for men in the preconception period to support clinical fertility outcomes.

OBJECTIVE AND RATIONALE

The purpose of this scoping review is to examine the extent and range of research undertaken to evaluate the effect(s) of diet in the preconception period on male clinical fertility and reproductive outcomes.

SEARCH METHODS

Four electronic databases (MEDLINE and EMBASE via Ovid, CAB Direct, and CINAHL via EBSCO) were searched from inception to July 2023 for randomized controlled trials (RCTs) and observational studies (prospective/retrospective, case-control, and cross-sectional). Intervention studies in male participants or couples aiming to achieve dietary or nutritional change, or non-intervention studies examining dietary or nutritional components (whole diets, dietary patterns, food groups or individual foods) in the preconception period were included. Controls were defined as any comparison group for RCTs, and any/no comparison for observational studies. Primary outcomes of interest included the effect(s) of male preconception diet on clinical outcomes such as conception (natural or via ART), pregnancy rates and live birth rates. Secondary outcomes included time to conception and sperm parameters.

OUTCOMES

A total of 37 studies were eligible, including one RCT and 36 observational studies (prospective, cross-sectional, and case-control studies; four studies in non-ART populations) published between 2008 and 2023. Eight reported clinical outcomes, 26 reported on secondary outcomes, and three reported on both. The RCT did not assess clinical outcomes but found that tomato juice may benefit sperm motility. In observational studies, some evidence suggested that increasing fish or reducing sugar-sweetened beverages, processed meat or total fat may improve fecundability. Evidence for other clinical outcomes, such as pregnancy rates or live birth rates, showed no relationship with cereals, soy and dairy, and inconsistent relationships with consuming red meat or a 'healthy diet' pattern. For improved sperm parameters, limited evidence supported increasing fish, fats/fatty acids, carbohydrates and dairy, and reducing processed meat, while the evidence for fruits, vegetables, cereals, legumes, eggs, red meat and protein was inconsistent. Healthy diet patterns in general were shown to improve sperm health.

WIDER IMPLICATIONS

Specific dietary recommendations for improving male fertility are precluded by the lack of reporting on clinical pregnancy outcomes, heterogeneity of the available literature and the paucity of RCTs to determine causation or to rule out reverse causation. There may be some benefit from increasing fish, adopting a healthy dietary pattern, and reducing consumption of sugar-sweetened beverages and processed meat, but it is unclear whether these benefits extend beyond sperm parameters to improve clinical fertility. More studies exploring whole diets rather than singular foods or nutritional components in the context of male fertility are encouraged, particularly by means of RCTs where feasible. Further assessment of core fertility outcomes is warranted and requires careful planning in high-quality prospective studies and RCTs. These studies can lay the groundwork for targeted dietary guidelines and enhance the prospects of successful fertility outcomes for men in the preconception period. Systematic search of preconception diet suggests that increasing fish and reducing sugary drinks, processed meats and total fat may improve male fertility, while consuming healthy diets, fish, fats/fatty acids, carbohydrates and dairy and reducing processed meat can improve sperm health.

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Affiliation(s)

Cathryn A Tully Adelaide Medical School, The University of Adelaide, Adelaide, SA, Australia Repromed, Dulwich, Adelaide, SA, Australia
Simon Alesi Monash Centre for Health Research and Implementation (MCHRI), Monash University, Clayton, VIC, Australia
Nicole O McPherson Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia Freemasons Center for Male Health and Wellbeing, The University of Adelaide, Adelaide, SA, Australia School of Biomedicine, Discipline of Reproduction and Development, The University of Adelaide, Adelaide, SA, Australia
David J Sharkey Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia School of Biomedicine, Discipline of Reproduction and Development, The University of Adelaide, Adelaide, SA, Australia
Xiao Tong Teong Adelaide Medical School, The University of Adelaide, Adelaide, SA, Australia Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia
Chau Thien Tay Monash Centre for Health Research and Implementation (MCHRI), Monash University, Clayton, VIC, Australia
Thais Rasia Silva Postgraduate Program in Endocrinology and Metabolism, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Carolyn Puglisi School of Agriculture, Food and Wine, Faculty of Sciences, University of Adelaide, Waite Campus, Urrbrae, SA, Australia
Jacqueline P Barsby Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia School of Agriculture, Food and Wine, Faculty of Sciences, University of Adelaide, Waite Campus, Urrbrae, SA, Australia
Lisa J Moran Monash Centre for Health Research and Implementation (MCHRI), Monash University, Clayton, VIC, Australia Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia
Jessica A Grieger Adelaide Medical School, The University of Adelaide, Adelaide, SA, Australia Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia
Aya Mousa Monash Centre for Health Research and Implementation (MCHRI), Monash University, Clayton, VIC, Australia

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Demirer B, Fisunoğlu M. Evaluation of the effects of dietary advanced glycation end products on inflammation. NUTR BULL 2024;49:6-18. [PMID: 38114851 DOI: 10.1111/nbu.12653] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/23/2023] [Revised: 11/16/2023] [Accepted: 11/20/2023] [Indexed: 12/21/2023]

Pereira VM, Pradhanang S, Prather JF, Nair S. Role of Metalloproteinases in Diabetes-associated Mild Cognitive Impairment. Curr Neuropharmacol 2024;23:58-74. [PMID: 38963109 PMCID: PMC11519823 DOI: 10.2174/1570159x22666240517090855] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/16/2023] [Revised: 01/24/2024] [Accepted: 02/14/2024] [Indexed: 07/05/2024] Open

Ma X, Ma J, Leng T, Yuan Z, Hu T, Liu Q, Shen T. Advances in oxidative stress in pathogenesis of diabetic kidney disease and efficacy of TCM intervention. Ren Fail 2023;45:2146512. [PMID: 36762989 PMCID: PMC9930779 DOI: 10.1080/0886022x.2022.2146512] [Citation(s) in RCA: 59] [Impact Index Per Article: 29.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 02/11/2023] Open

Ansari MA, Chauhan W, Shoaib S, Alyahya SA, Ali M, Ashraf H, Alomary MN, Al-Suhaimi EA. Emerging therapeutic options in the management of diabetes: recent trends, challenges and future directions. Int J Obes (Lond) 2023;47:1179-1199. [PMID: 37696926 DOI: 10.1038/s41366-023-01369-3] [Citation(s) in RCA: 14] [Impact Index Per Article: 7.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/09/2023] [Revised: 07/04/2023] [Accepted: 08/17/2023] [Indexed: 09/13/2023]

Abstract

Diabetes is a serious health issue that causes a progressive dysregulation of carbohydrate metabolism due to insufficient insulin hormone, leading to consistently high blood glucose levels. According to the epidemiological data, the prevalence of diabetes has been increasing globally, affecting millions of individuals. It is a long-term condition that increases the risk of various diseases caused by damage to small and large blood vessels. There are two main subtypes of diabetes: type 1 and type 2, with type 2 being the most prevalent. Genetic and molecular studies have identified several genetic variants and metabolic pathways that contribute to the development and progression of diabetes. Current treatments include gene therapy, stem cell therapy, statin therapy, and other drugs. Moreover, recent advancements in therapeutics have also focused on developing novel drugs targeting these pathways, including incretin mimetics, SGLT2 inhibitors, and GLP-1 receptor agonists, which have shown promising results in improving glycemic control and reducing the risk of complications. However, these treatments are often expensive, inaccessible to patients in underdeveloped countries, and can have severe side effects. Peptides, such as glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), are being explored as a potential therapy for diabetes. These peptides are postprandial glucose-dependent pancreatic beta-cell insulin secretagogues and have received much attention as a possible treatment option. Despite these advances, diabetes remains a major health challenge, and further research is needed to develop effective treatments and prevent its complications. This review covers various aspects of diabetes, including epidemiology, genetic and molecular basis, and recent advancements in therapeutics including herbal and synthetic peptides.

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Horvat A, Vlašić I, Štefulj J, Oršolić N, Jazvinšćak Jembrek M. Flavonols as a Potential Pharmacological Intervention for Alleviating Cognitive Decline in Diabetes: Evidence from Preclinical Studies. Life (Basel) 2023;13:2291. [PMID: 38137892 PMCID: PMC10744738 DOI: 10.3390/life13122291] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/30/2023] [Revised: 11/15/2023] [Accepted: 11/24/2023] [Indexed: 12/24/2023] Open

Bana S, Kumar N, Sartaj A, Alhalmi A, Qurtam AA, Nasr FA, Al-Zharani M, Singh N, Gaur P, Mishra R, Bhardwaj S, Ali H, Goel R. Rubia cordifolia L. Attenuates Diabetic Neuropathy by Inhibiting Apoptosis and Oxidative Stress in Rats. Pharmaceuticals (Basel) 2023;16:1586. [PMID: 38004451 PMCID: PMC10674165 DOI: 10.3390/ph16111586] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/18/2023] [Revised: 10/12/2023] [Accepted: 11/06/2023] [Indexed: 11/26/2023] Open

Abstract

BACKGROUND

Diabetic neuropathy is a debilitating manifestation of long-term diabetes mellitus. The present study explored the effects of the roots of Rubia cordifolia L. (R. cordifolia L.) in the Wistar rat model for diabetic neuropathy and possible neuroprotective, antidiabetic, and analgesic mechanisms underlying this effect.

MATERIALS AND METHODS

Rats were divided into five experimental groups. An amount of 0.25% carboxy methyl cellulose (CMC) in saline and streptozotocin (STZ) (60 mg/kg) was given to group 1 and group 2, respectively. Group 3 was treated with STZ and glibenclamide simultaneously while groups 4 and 5 were simultaneously treated with STZ and hydroalcoholic extract of the root of R. cordifolia, respectively. Hot plate and cold allodynias were used to evaluate the pain threshold. The antioxidant effects of R. cordifolia were assessed by measuring Thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD). At the end of the study, sciatic nerve and brain tissues were collected for histopathological study. Bcl-2 proteins, cleaved caspase-3, and Bax were assessed through the Western blot method.

RESULTS

R. cordifolia significantly attenuated paw withdrawal and tail flick latency in diabetic neuropathic rats. R. cordifolia significantly (p < 0.01) improved the levels of oxidative stress. It was found to decrease blood glucose levels and to increase animal weight in R. cordifolia-treated groups. Treatment with R. cordifolia suppressed the cleaved caspase-3 and reduced the Bax:Bcl2 ratio in sciatic nerve and brain tissue compared to the diabetic group. Histopathological analysis also revealed a marked improvement in architecture and loss of axons in brain and sciatic nerve tissues at a higher dose of R. cordifolia (400 mg/kg).

CONCLUSION

R. cordifolia attenuated diabetic neuropathy through its antidiabetic and analgesic properties by ameliorating apoptosis and oxidative stress.

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An JR, Wang QF, Sun GY, Su JN, Liu JT, Zhang C, Wang L, Teng D, Yang YF, Shi Y. The Role of Iron Overload in Diabetic Cognitive Impairment: A Review. Diabetes Metab Syndr Obes 2023;16:3235-3247. [PMID: 37872972 PMCID: PMC10590583 DOI: 10.2147/dmso.s432858] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/28/2023] [Accepted: 09/29/2023] [Indexed: 10/25/2023] Open

Affiliation(s)

Ji-Ren An Liaoning Key Laboratory of Chinese Medicine Combining Disease and Syndrome of Diabetes, Liaoning University of Traditional Chinese Medicine, Shenyang, 110847, People’s Republic of China College of Integrative Chinese and Western Medicine, Hebei University of Chinese Medicine, Shijiazhuang, 050200, People’s Republic of China
Qing-Feng Wang Liaoning Key Laboratory of Chinese Medicine Combining Disease and Syndrome of Diabetes, Liaoning University of Traditional Chinese Medicine, Shenyang, 110847, People’s Republic of China
Gui-Yan Sun Liaoning Key Laboratory of Chinese Medicine Combining Disease and Syndrome of Diabetes, Liaoning University of Traditional Chinese Medicine, Shenyang, 110847, People’s Republic of China
Jia-Nan Su Liaoning Key Laboratory of Chinese Medicine Combining Disease and Syndrome of Diabetes, Liaoning University of Traditional Chinese Medicine, Shenyang, 110847, People’s Republic of China
Jun-Tong Liu Liaoning Key Laboratory of Chinese Medicine Combining Disease and Syndrome of Diabetes, Liaoning University of Traditional Chinese Medicine, Shenyang, 110847, People’s Republic of China
Chi Zhang Liaoning Key Laboratory of Chinese Medicine Combining Disease and Syndrome of Diabetes, Liaoning University of Traditional Chinese Medicine, Shenyang, 110847, People’s Republic of China
Li Wang Liaoning Key Laboratory of Chinese Medicine Combining Disease and Syndrome of Diabetes, Liaoning University of Traditional Chinese Medicine, Shenyang, 110847, People’s Republic of China
Dan Teng He University, Shenyang, 110163, People’s Republic of China
Yu-Feng Yang Liaoning Key Laboratory of Chinese Medicine Combining Disease and Syndrome of Diabetes, Liaoning University of Traditional Chinese Medicine, Shenyang, 110847, People’s Republic of China
Yan Shi Liaoning Key Laboratory of Chinese Medicine Combining Disease and Syndrome of Diabetes, Liaoning University of Traditional Chinese Medicine, Shenyang, 110847, People’s Republic of China

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Bansal S, Burman A, Tripathi AK. Advanced glycation end products: Key mediator and therapeutic target of cardiovascular complications in diabetes. World J Diabetes 2023;14:1146-1162. [PMID: 37664478 PMCID: PMC10473940 DOI: 10.4239/wjd.v14.i8.1146] [Citation(s) in RCA: 17] [Impact Index Per Article: 8.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/29/2023] [Revised: 03/21/2023] [Accepted: 05/22/2023] [Indexed: 08/11/2023] Open

Abstract

The incidence of type 2 diabetes mellitus is growing in epidemic proportions and has become one of the most critical public health concerns. Cardiovascular complications associated with diabetes are the leading cause of morbidity and mortality. The cardiovascular diseases that accompany diabetes include angina, myocardial infarction, stroke, peripheral artery disease, and congestive heart failure. Among the various risk factors generated secondary to hyperglycemic situations, advanced glycation end products (AGEs) are one of the important targets for future diagnosis and prevention of diabetes. In the last decade, AGEs have drawn a lot of attention due to their involvement in diabetic patho-physiology. AGEs can be derived exogenously and endogenously through various pathways. These are a non-homogeneous, chemically diverse group of compounds formed non-enzymatically by condensation between carbonyl groups of reducing sugars and free amino groups of protein, lipids, and nucleic acid. AGEs mediate their pathological effects at the cellular and extracellular levels by multiple pathways. At the cellular level, they activate signaling cascades via the receptor for AGEs and initiate a complex series of intracellular signaling resulting in reactive oxygen species generation, inflammation, cellular proliferation, and fibrosis that may possibly exacerbate the damaging effects on cardiac functions in diabetics. AGEs also cause covalent modifications and cross-linking of serum and extracellular matrix proteins; altering their structure, stability, and functions. Early diagnosis of diabetes may prevent its progression to complications and decrease its associated comorbidities. In the present review, we recapitulate the role of AGEs as a crucial mediator of hyperglycemia-mediated detrimental effects in diabetes-associated complications. Furthermore, this review presents an overview of future perspectives for new therapeutic interventions to ameliorate cardiovascular complications in diabetes.

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Taheriazam A, Entezari M, Firouz ZM, Hajimazdarany S, Hossein Heydargoy M, Amin Moghadassi AH, Moghadaci A, Sadrani A, Motahhary M, Harif Nashtifani A, Zabolian A, Tabari T, Hashemi M, Raesi R, Jiang M, Zhang X, Salimimoghadam S, Ertas YN, Sun D. Eco-friendly chitosan-based nanostructures in diabetes mellitus therapy: Promising bioplatforms with versatile therapeutic perspectives. ENVIRONMENTAL RESEARCH 2023;228:115912. [PMID: 37068723 DOI: 10.1016/j.envres.2023.115912] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 03/21/2023] [Revised: 04/04/2023] [Accepted: 04/13/2023] [Indexed: 05/16/2023]

Affiliation(s)

Afshin Taheriazam Department of Orthopedics, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Maliheh Entezari Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Zeinab Mohammadi Firouz Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Shima Hajimazdarany Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Department of Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Mohammad Hossein Heydargoy Department of Microbiology, Shahr-e Ghods Branch, Islamic Azad University, Tehran, Iran
Amir Hossein Amin Moghadassi Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Ali Moghadaci Aja University of Medical Sciences, Tehran, Iran
Amin Sadrani Department of Orthopedics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Motahhar Motahhary General Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Abdorrahman Harif Nashtifani Department of Health Care Management, Zahedan University of Medical Sciences, Zahedan, Iran
Amirhossein Zabolian Department of Orthopedics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Teimour Tabari Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Mehrdad Hashemi Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Rasoul Raesi Mashhad University of Medical Sciences, Mashhad, Iran; Department of Medical-Surgical Nursing, Mashhad University of Medical Sciences, Mashhad, Iran.
Mengyuan Jiang Department of Cardiology, Xijing Hospital, The Fourth Military Medical University, China
Xuebin Zhang Department of Cardiology, Xijing Hospital, The Fourth Military Medical University, China
Shokooh Salimimoghadam Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Yavuz Nuri Ertas Department of Biomedical Engineering, Erciyes University, Kayseri, Turkey; ERNAM-Nanotechnology Research and Application Center, Erciyes University, Kayseri, Turkey.
Dongdong Sun Department of Cardiology, Xijing Hospital, The Fourth Military Medical University, China.

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Qiu L, Chen K, Wang X, Zhao Y. RETRACTED: Tangzhiqing-mediated NRF2 reduces autophagy-dependent ferroptosis to mitigate diabetes-related cognitive impairment neuronal damage. Rejuvenation Res 2023. [PMID: 37279293 DOI: 10.1089/rej.2023.0013] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 06/08/2023] Open

Abstract

The publisher of Rejuvenation Research officially retracts the article entitled, "Tangzhiqing-mediated NRF2 reduces autophagy-dependent ferroptosis to mitigate diabetes-related cognitive impairment neuronal damage," by Lingyan Qiu, Mr. Kai Chen, Prof. Xu Wang, and Ms. Yun Zhao. (Rejuvenation Res 2023; epub 6 Jun; doi: 10.1089/rej.2023.0013). After the acceptance and Instant Online publication of the paper, the authors were contacted repeatedly regarding their page proofs, and for further clarification of unresolved issues within the paper. All attempts to reach the authors were unsuccessful. Concurrently, the publisher identified a problematic overlap with a paper published in 2023 in Endocrine, Metabolic & Immune Disorders - Drug Targets.1 This paper was subsequently withdrawn. These troubling details have led the editorial leadership of Rejuvenation Research to lose confidence in the validity of the submission and to retract the paper. All authors were notified of the decision to retract the paper via email. The lead author, Lingyan Qiu, and the corresponding author, Xu Wang, quickly responded and appealed the decision to retract. The appeal was denied. Reference 1. https://www.eurekaselect.com/article/132631. Withdrawn: Experimental study on NRF2 mediated by Chinese medicine tangzhiqing to reduce autophagy-dependent ferroptosis and alleviate neuron damage in HT22 mice with diabetes-related cognitive disorder. 22 June, 2023; DOI: 10.2174/1871530323666230622151649 Diabetes is a chronic condition defined by the body's inability to process glucose. The most common form, diabetes mellitus, reflects the body's insulin resistance, which leads to long-term raised glucose blood levels. These levels can cause oxidative damage, cell stress, and excessive autophagy throughout the body, including the nervous system. Diabetes-related cognitive impairment (DCI) results from chronic elevation of blood glucose, and as diabetes cases continue to rise, so too do comorbidities such as DCI. Although there are medications to address high blood glucose, there are few that can inhibit excessive autophagy and cell death. Therefore, we investigated if the Traditional Chinese Medicine, Tangzhiqing (TZQ), can reduce the impact of DCI in a high-glucose cell model. We used commercially available kits to evaluate cell viability, mitochondrial activity, and oxidative stress. We found that TZQ treatment increased cell viability, ensured continued mitochondrial activity, and reduced reactive oxygen species. We also found that TZQ functions by increasing NRF2 activity, which decreases the ferroptotic-associated pathways that involve p62, HO-1, and GPX4. Therefore, TZQ should be further investigated for its role in reducing DCI.

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Bellavite P, Fazio S, Affuso F. A Descriptive Review of the Action Mechanisms of Berberine, Quercetin and Silymarin on Insulin Resistance/Hyperinsulinemia and Cardiovascular Prevention. Molecules 2023;28:4491. [PMID: 37298967 PMCID: PMC10254920 DOI: 10.3390/molecules28114491] [Citation(s) in RCA: 7] [Impact Index Per Article: 3.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/16/2023] [Revised: 05/26/2023] [Accepted: 05/30/2023] [Indexed: 06/12/2023] Open

Nesterowicz M, Lauko KK, Żendzian-Piotrowska M, Ładny JR, Zalewska A, Maciejczyk M. Agomelatine's antiglycoxidative action-In vitro and in silico research and systematic literature review. Front Psychiatry 2023;14:1164459. [PMID: 37181902 PMCID: PMC10166843 DOI: 10.3389/fpsyt.2023.1164459] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/12/2023] [Accepted: 03/24/2023] [Indexed: 05/16/2023] Open

Muzaffar H, Qamar I, Bashir M, Jabeen F, Irfan S, Anwar H. Gymnema Sylvestre Supplementation Restores Normoglycemia, Corrects Dyslipidemia, and Transcriptionally Modulates Pancreatic and Hepatic Gene Expression in Alloxan-Induced Hyperglycemic Rats. Metabolites 2023;13:metabo13040516. [PMID: 37110174 PMCID: PMC10142569 DOI: 10.3390/metabo13040516] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/10/2022] [Revised: 03/17/2023] [Accepted: 03/20/2023] [Indexed: 04/07/2023] Open

Bhatt HD, Golub LM, Lee HM, Kim J, Zimmerman T, Deng J, Hong H, Johnson F, Gu Y. Efficacy of a Novel Pleiotropic MMP-Inhibitor, CMC2.24, in a Long-Term Diabetes Rat Model with Severe Hyperglycemia-Induced Oral Bone Loss. J Inflamm Res 2023;16:779-792. [PMID: 36860795 PMCID: PMC9969803 DOI: 10.2147/jir.s399043] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/25/2022] [Accepted: 02/03/2023] [Indexed: 02/24/2023] Open

Abstract

Purpose

CMC2.24, a novel 4-(phenylaminocarbonyl)-chemically-modified-curcumin, is a pleiotropic MMP-Inhibitor of various inflammatory/collagenolytic diseases including periodontitis. This compound has demonstrated efficacy in host modulation therapy along with improved resolution of inflammation in various study models. The objective of current study is to determine the efficacy of CMC2.24 in reducing the severity of diabetes, and its long-term role as an MMP-inhibitor, in a rat model.

Methods

Twenty-one adult male Sprague-Dawley rats were randomly distributed into three groups: Normal (N), Diabetic (D) and Diabetic+CMC2.24 (D+2.24). All three groups were orally administered vehicle: carboxymethylcellulose alone (N, D), or CMC2.24 (D+2.24; 30mg/kg/day). Blood was collected at 2-months and 4-months' time-point. At completion, gingival tissue and peritoneal washes were collected/analyzed, and jaws examined for alveolar bone loss by micro-CT. Additionally, sodium hypochlorite(NaClO)-activation of human-recombinant (rh) MMP-9 and its inhibition by treatment with 10μM CMC2.24, Doxycycline, and Curcumin were evaluated.

Results

CMC2.24 significantly reduced the levels of lower-molecular-weight active-MMP-9 in plasma. Similar trend of reduced active-MMP-9 was also observed in cell-free peritoneal and pooled gingival extracts. Thus, treatment substantially decreased conversion of pro- to actively destructive proteinase. Normalization of the pro-inflammatory cytokine (IL-1ß, resolvin-RvD1), and diabetes-induced osteoporosis was observed in presence of CMCM2.24. CMC2.24 also exhibited significant anti-oxidant activity by inhibiting the activation of MMP-9 to a lower-molecular-weight (82kDa) pathologically active form. All these systemic and local effects were observed in the absence of reduction in severity of hyperglycemia.

Conclusion

CMC2.24 reduced activation of pathologic active-MMP-9, normalized diabetic osteoporosis, and promoted resolution of inflammation but had no effect on the hyperglycemia in diabetic rats. This study also highlights the role of MMP-9 as an early/sensitive biomarker in the absence of change in any other biochemical parameter. CMC2.24 also inhibited significant activation of pro-MMP-9 by NaOCl (oxidant) adding to known mechanisms by which this compound treats collagenolytic/inflammatory diseases including periodontitis.

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Rajlic S, Treede H, Münzel T, Daiber A, Duerr GD. Early Detection Is the Best Prevention-Characterization of Oxidative Stress in Diabetes Mellitus and Its Consequences on the Cardiovascular System. Cells 2023;12:583. [PMID: 36831253 PMCID: PMC9954643 DOI: 10.3390/cells12040583] [Citation(s) in RCA: 5] [Impact Index Per Article: 2.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/30/2022] [Revised: 02/05/2023] [Accepted: 02/08/2023] [Indexed: 02/16/2023] Open

Feng X, Wang X, Zhou L, Pang S, Tang H. The impact of glucose on mitochondria and life span is determined by the integrity of proline catabolism in Caenorhabditis elegans. J Biol Chem 2023;299:102881. [PMID: 36626986 PMCID: PMC9932108 DOI: 10.1016/j.jbc.2023.102881] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/21/2022] [Revised: 12/28/2022] [Accepted: 12/31/2022] [Indexed: 01/09/2023] Open

Hu ZP, Wu F, Du YH, Ye M. Association between serum complement 1q and the associated factors of acute ischemic stroke in patients with type 2 diabetes. Hum Exp Toxicol 2023;42:9603271231188291. [PMID: 37550830 DOI: 10.1177/09603271231188291] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 08/09/2023]

Martemucci G, Portincasa P, Centonze V, Mariano M, Khalil M, D'Alessandro AG. Prevention of Oxidative Stress and Diseases by Antioxidant Supplementation. Med Chem 2023;19:509-537. [PMID: 36453505 DOI: 10.2174/1573406419666221130162512] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/27/2022] [Revised: 09/02/2022] [Accepted: 09/27/2022] [Indexed: 12/03/2022]

Agarwal P, Ford CN, Leurgans SE, Beck T, Desai P, Dhana K, Evans DA, Halloway S, Holland TM, Krueger KR, Liu X, Rajan KB, Bennett DA. Dietary Sugar Intake Associated with a Higher Risk of Dementia in Community-Dwelling Older Adults. J Alzheimers Dis 2023;95:1417-1425. [PMID: 37694364 PMCID: PMC10921393 DOI: 10.3233/jad-230013] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 09/12/2023]

Affiliation(s)

Puja Agarwal Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA Department of Clinical Nutrition, Rush University Medical Center, Chicago, IL, USA
Christopher N. Ford Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA Rush Institute for Healthy Aging (Section of Community Epidemiology), Rush University Medical Center, Chicago, IL, USA
Sue E. Leurgans Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA Department of Neurology, Rush University Medical Center, Chicago, IL, USA
Todd Beck Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA Rush Institute for Healthy Aging (Section of Community Epidemiology), Rush University Medical Center, Chicago, IL, USA
Pankaja Desai Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA Rush Institute for Healthy Aging (Section of Community Epidemiology), Rush University Medical Center, Chicago, IL, USA
Klodian Dhana Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA Rush Institute for Healthy Aging (Section of Community Epidemiology), Rush University Medical Center, Chicago, IL, USA
Denis A. Evans Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA Rush Institute for Healthy Aging (Section of Community Epidemiology), Rush University Medical Center, Chicago, IL, USA
Shannon Halloway Department of Biobehavioral Nursing Science, College of Nursing, University of Illinois Chicago, Chicago, IL, USA
Thomas M. Holland Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA Rush Institute for Healthy Aging (Section of Community Epidemiology), Rush University Medical Center, Chicago, IL, USA
Kristin R. Krueger Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA Rush Institute for Healthy Aging (Section of Community Epidemiology), Rush University Medical Center, Chicago, IL, USA
Xiaoran Liu Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA Rush Institute for Healthy Aging (Section of Community Epidemiology), Rush University Medical Center, Chicago, IL, USA
Kumar Bharat Rajan Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA Rush Institute for Healthy Aging (Section of Community Epidemiology), Rush University Medical Center, Chicago, IL, USA
David A. Bennett Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA Department of Neurology, Rush University Medical Center, Chicago, IL, USA

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Dupak R, Hrnkova J, Simonova N, Kovac J, Ivanisova E, Kalafova A, Schneidgenova M, Prnova MS, Brindza J, Tokarova K, Capcarova M. The consumption of sea buckthorn (Hippophae rhamnoides L.) effectively alleviates type 2 diabetes symptoms in spontaneous diabetic rats. Res Vet Sci 2022;152:261-269. [PMID: 36063603 DOI: 10.1016/j.rvsc.2022.08.022] [Citation(s) in RCA: 7] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/09/2022] [Accepted: 08/25/2022] [Indexed: 11/29/2022]

Affiliation(s)

Rudolf Dupak Institute of Applied Biology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Trieda Andreja Hlinku 2, 949 76 Nitra, Slovak Republic.
Jana Hrnkova Institute of Applied Biology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Trieda Andreja Hlinku 2, 949 76 Nitra, Slovak Republic.
Nikoleta Simonova Institute of Applied Biology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Trieda Andreja Hlinku 2, 949 76 Nitra, Slovak Republic.
Jan Kovac Institute of Applied Biology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Trieda Andreja Hlinku 2, 949 76 Nitra, Slovak Republic.
Eva Ivanisova Institute of Food Sciences, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Trieda Andreja Hlinku 2, 949 76 Nitra, Slovak Republic.
Anna Kalafova Institute of Applied Biology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Trieda Andreja Hlinku 2, 949 76 Nitra, Slovak Republic.
Monika Schneidgenova Institute of Applied Biology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Trieda Andreja Hlinku 2, 949 76 Nitra, Slovak Republic.
Marta Soltesova Prnova Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Science, Dubravska cesta 9, 841 04 Bratislava, Slovak Republic.
Jan Brindza Institute of Plant and Environmental Sciences, Faculty of Agrobiology and Food Resources, Slovak University of Agriculture in Nitra, Trieda Andreja Hlinku 2, 949 76 Nitra, Slovak Republic.
Katarina Tokarova Institute of Applied Biology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Trieda Andreja Hlinku 2, 949 76 Nitra, Slovak Republic.
Marcela Capcarova Institute of Applied Biology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Trieda Andreja Hlinku 2, 949 76 Nitra, Slovak Republic.

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(−)-Epigallocatechin gallate (EGCG) pharmacokinetics and molecular interactions towards amelioration of hyperglycemia, hyperlipidemia associated hepatorenal oxidative injury in alloxan induced diabetic mice. Chem Biol Interact 2022;368:110230. [DOI: 10.1016/j.cbi.2022.110230] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/30/2022] [Revised: 09/29/2022] [Accepted: 10/19/2022] [Indexed: 01/18/2023]

Long C, Yoon MS. Psychometric properties of the Chinese version of the sugar-sweetened beverages media literacy scale for undergraduates. Front Public Health 2022;10:1009838. [PMID: 36311605 PMCID: PMC9615564 DOI: 10.3389/fpubh.2022.1009838] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/02/2022] [Accepted: 09/27/2022] [Indexed: 01/27/2023] Open

Arabzadeh E, Shirvani H, Ebadi Zahmatkesh M, Riyahi Malayeri S, Meftahi GH, Rostamkhani F. Irisin/FNDC5 influences myogenic markers on skeletal muscle following high and moderate-intensity exercise training in STZ-diabetic rats. 3 Biotech 2022;12:193. [PMID: 35910290 PMCID: PMC9325938 DOI: 10.1007/s13205-022-03253-9] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/19/2022] [Accepted: 07/03/2022] [Indexed: 11/29/2022] Open

Detection and Quantification of Nanoparticle-Induced Intracellular ROS in Live Cells by Laser Scanning Confocal Microscopy. Methods 2022;207:11-19. [PMID: 36028162 DOI: 10.1016/j.ymeth.2022.08.005] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/11/2022] [Revised: 07/29/2022] [Accepted: 08/12/2022] [Indexed: 12/07/2022] Open

Abstract

All living organisms utilise reactive oxygen species (ROS) for essential cellular functions, the majority of which involve signal transduction pathways, such as enzyme regulation, cell growth and differentiation signalling, and inflammation mediation. Increased ROS in cancer cells can be caused by abnormalities in the tumor environment. However, using fluorescence microscopy to detect and quantify ROS changes in biological systems is difficult for several reasons: (1) lack of specificity of ROS-sensitive probes, (2) high turnover of ROS species, (3) rapid decrease in ROS fluorescence with time, and (4) detection and quantification techniques with insufficient sensitivity. Existing approaches to ROS measurement using confocal microscopy imaging focus solely on ROS detection rather than quantification. A novel fluorescence-based ROS detection and quantification technique has been developed for the purpose of resolving the limitations of existing methods. In general, ROS is detected by fluorescence using instrumentation such as flow cytometry and laser scanning confocal microscopy. However, these approaches confirm only the presence or absence of ROS; they are not quantitative, which is essential for therapeutic applications. In the newly developed technique, cerium-based ROS-generating nanoparticles have been used to elevate the ROS in HT-1080 fibrosarcoma cells. The elevated ROS levels are detected using an H2DCFDA fluorescence probe, which is used widely for this application, and captured as digital images using a 488 nm fluorescence channel. Quantification of the ROS is achieved using script in MATLAB software to convert the fluorescence intensities to numerical values. Thus, this technique nearly simultaneously integrates both detection and quantification of the ROS, which provides the statistical justification necessary to support therapeutic translation.

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Farid M, Aboul Naser AF, Salem M, Ahmed YR, Emam M, Hamed MA. Chemical compositions of Commiphora opobalsamum stem bark to alleviate liver complications in streptozotocin-induced diabetes in rats: Role of oxidative stress and DNA damage. Biomarkers 2022;27:671-683. [DOI: 10.1080/1354750x.2022.2099015] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/02/2022]

Chang R, Tu TY, Hung YM, Huang JY, Chou MC, Wei JCC. Metformin use is associated with a lower risk of rotator cuff disease in patients with type 2 diabetes mellitus. DIABETES & METABOLISM 2022;48:101368. [PMID: 35760373 DOI: 10.1016/j.diabet.2022.101368] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 02/11/2022] [Revised: 06/15/2022] [Accepted: 06/17/2022] [Indexed: 11/25/2022]

Abstract

AIMS

- Metformin has been mentioned to be protective against inflammation, degeneration, and oxidative stress, conditions that are associated with rotator cuff disease. To access the association between metformin use and risk of rotator cuff disease in patients with type 2 diabetes mellitus (DM).

METHODS

- This was a retrospective cohort study utilizing Taiwan National Health Insurance Research Database between January 1, 2000, and December 31, 2012 to retrieved participants. Metformin and propensity score matched never metformin users were determined at baseline (between the date of onset of DM and the index date), and followed to December 31, 2013. Propensity scores were adopted to address measurable confounders (including demographic variables, Diabetes Complications Severity Index, and relevant comorbidities and co-medication). A multivariable Cox proportional hazards regression model was applied to estimate the adjusted hazard ratios (HRs) for the risk of the first diagnosis of rotator cuff disease on the full cohort and on the propensity score matched cohort.

RESULTS

- In the propensity score matched cohort, a total of 34,964 individuals (19,416 [55.5%] men), 17,482 individuals were taking metformin, 559 [3.2%] of whom developed rotator cuff disease. Incidence of rotator cuff disease was 4.51 per 10,000 person-months in the metformin users and 5.11 in the controls. Among metformin group, the aHR (95% CI) was 0.879 (0.784-0.984) after full adjustment. The potential beneficial effect on the risk of rotator cuff disease was consistently observed across all subgroups, including sex, age, concomitant other glucose lowering drugs, and level of Diabetes Complications Severity Index (all P for interaction > 0.050).

CONCLUSION

- Metformin use was associated with a lower risk of rotator cuff disease in patients with type 2 DM.

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Park JG, Iwata H, Tue NM, Kunisue T, Kim EY. Effects of 1,3,7-tribromodibenzo-p-dioxin, a natural dioxin on chicken embryos: Comparison with effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 2022;237:113538. [PMID: 35483143 DOI: 10.1016/j.ecoenv.2022.113538] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 12/30/2021] [Revised: 04/15/2022] [Accepted: 04/16/2022] [Indexed: 06/14/2023]

Abstract

Several naturally occurring dioxins, including 1,3,7-tribromodibenzo-p-dioxin (1,3,7-TriBDD), synthesized by red algae, have been detected in the marine environment. As 1,3,7-TriBDD is accumulated in mussels and fish, predators, such as marine birds, are exposed to this congener, similar to anthropogenic dioxins (including 2,3,7,8-tetrachlorodibenzo-p-dioxin TCDD). However, little is known about the impact of 1,3,7-TriBDD exposure on the bird health. To understand the effects of 1,3,7-TriBDD on birds, the phenotypic effects and hepatic transcriptome were investigated in chicken (Gallus gallus) embryos treated with 27 μM (2.9 ng/g egg) and 137 μM (14.4 ng/g egg) 1,3,7-TriBDD. The blood glucose levels in the 1,3,7-TriBDD-treated groups were lower than those in the control group. The transcriptome analysis of 6520 sequences in the 27 and 137 μM 1,3,7-TriBDD-treated groups identified 733 and 596 differentially expressed genes (DEGs). Cytochrome P450 1A4 and 1A5 were also identified as DEGs, suggesting that the aryl hydrocarbon receptor is activated by this congener. Pathway and network analyses with DEGs suggested that 1,3,7-TriBDD may induce carcinogenic effects and metabolic alterations. These results were similar to the effects on TCDD-treated embryos. Nevertheless, the overall transcriptome results suggested that compared with TCDD, 1,3,7-TriBDD has a unique impact on insulin- and peroxisome-signaling pathways in chicken embryos. Differences in altered transcriptome profiles between 1,3,7-TriBDD- and TCDD-treated embryos may lead to different phenotypic effects: less severe effects of 1,3,7-TriBDD and more fatal effects of TCDD. Collectively, these findings warrant the further assessment of the hazard and risk of 1,3,7-TriBDD on marine animals, considering increased exposure due to climate change.

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Curcumin, Polydatin and Quercetin Synergistic Activity Protects from High-Glucose-Induced Inflammation and Oxidative Stress. Antioxidants (Basel) 2022;11:antiox11061037. [PMID: 35739934 PMCID: PMC9220232 DOI: 10.3390/antiox11061037] [Citation(s) in RCA: 10] [Impact Index Per Article: 3.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/28/2022] [Revised: 05/18/2022] [Accepted: 05/19/2022] [Indexed: 11/30/2022] Open

El Okle OS, Tohamy HG, Althobaiti SA, Soliman MM, Ghamry HI, Farrag F, Shukry M. Ornipural® Mitigates Malathion-Induced Hepato-Renal Damage in Rats via Amelioration of Oxidative Stress Biomarkers, Restoration of Antioxidant Activity, and Attenuation of Inflammatory Response. Antioxidants (Basel) 2022;11:antiox11040757. [PMID: 35453442 PMCID: PMC9031224 DOI: 10.3390/antiox11040757] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/03/2022] [Revised: 04/07/2022] [Accepted: 04/08/2022] [Indexed: 02/01/2023] Open

Abstract

The current study was instigated by investigating the ameliorative potential of Ornipural^® solution against the hepato-renal toxicity of malathion. A total number of 35 male Wistar albino rats were divided equally into five groups. Group 1 served as control and received normal saline intraperitoneally. Group 2, the sham group, were administered only corn oil (vehicle of malathion) orally. Group 3 was orally intoxicated by malathion in corn oil at a dose of 135 mg/kg BW via intra-gastric gavage. Group 4 received malathion orally concomitantly with Ornipural^® intraperitoneally. Group 5 was given Ornipural^® solution in saline via intraperitoneal injection at a dose of (1 mL/kg BW). Animals received the treatment regime for 30 days. Histopathological examination revealed the harmful effect of malathion on hepatic and renal tissue. The results showed that malathion induced a significant decrease in body weight and marked elevation in the activity of liver enzymes, LDH, and ACP. In contrast, the activity of AchE and Paraoxonase was markedly decreased. Moreover, there was a significant increase in the serum content of bilirubin, cholesterol, and kidney injury markers. A significant elevation in malondialdehyde, nitric oxide (nitrite), and 8-hydroxy-2-deoxyguanosine was observed, along with a substantial reduction in antioxidant activity. Furthermore, malathion increased tumor necrosis factor-alpha, the upregulation of IL-1B, BAX, and IFN-β genes, and the downregulation of Nrf2, Bcl2, and HO-1 genes. Concurrent administration of Ornipural^® with malathion attenuated the detrimental impact of malathion through ameliorating metabolic biomarkers, restoring antioxidant activity, reducing the inflammatory response, and improving pathologic microscopic alterations. It could be concluded that Ornipural^® solution demonstrates hepatorenal defensive impacts against malathion toxicity at biochemical, antioxidants, molecular, and cellular levels.

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Merabet N, Lucassen PJ, Crielaard L, Stronks K, Quax R, Sloot PMA, la Fleur SE, Nicolaou M. How exposure to chronic stress contributes to the development of type 2 diabetes: A complexity science approach. Front Neuroendocrinol 2022;65:100972. [PMID: 34929260 DOI: 10.1016/j.yfrne.2021.100972] [Citation(s) in RCA: 22] [Impact Index Per Article: 7.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/15/2021] [Revised: 11/24/2021] [Accepted: 12/12/2021] [Indexed: 11/18/2022]

Affiliation(s)

Nadège Merabet Department of Public and Occupational Health, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health Research Institute, Meibergdreef 9, Amsterdam, the Netherlands; Institute for Advanced Study, University of Amsterdam, Amsterdam 1012 GC, the Netherlands; Centre for Urban Mental Health, University of Amsterdam, Amsterdam 1012 GC, the Netherlands
Paul J Lucassen Centre for Urban Mental Health, University of Amsterdam, Amsterdam 1012 GC, the Netherlands; Brain Plasticity Group, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam 1098 XH, the Netherlands
Loes Crielaard Department of Public and Occupational Health, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health Research Institute, Meibergdreef 9, Amsterdam, the Netherlands; Institute for Advanced Study, University of Amsterdam, Amsterdam 1012 GC, the Netherlands
Karien Stronks Department of Public and Occupational Health, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health Research Institute, Meibergdreef 9, Amsterdam, the Netherlands; Institute for Advanced Study, University of Amsterdam, Amsterdam 1012 GC, the Netherlands; Centre for Urban Mental Health, University of Amsterdam, Amsterdam 1012 GC, the Netherlands
Rick Quax Institute for Advanced Study, University of Amsterdam, Amsterdam 1012 GC, the Netherlands; Computational Science Lab, University of Amsterdam, Amsterdam 1098 XH, the Netherlands
Peter M A Sloot Institute for Advanced Study, University of Amsterdam, Amsterdam 1012 GC, the Netherlands; Centre for Urban Mental Health, University of Amsterdam, Amsterdam 1012 GC, the Netherlands; Computational Science Lab, University of Amsterdam, Amsterdam 1098 XH, the Netherlands; National Centre of Cognitive Research, ITMO University, St. Petersburg, Russian Federation
Susanne E la Fleur Department of Endocrinology and Metabolism & Laboratory of Endocrinology, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands; Metabolism and Reward Group, Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, Amsterdam, the Netherlands.
Mary Nicolaou Department of Public and Occupational Health, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health Research Institute, Meibergdreef 9, Amsterdam, the Netherlands; Institute for Advanced Study, University of Amsterdam, Amsterdam 1012 GC, the Netherlands; Centre for Urban Mental Health, University of Amsterdam, Amsterdam 1012 GC, the Netherlands.

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Peng D, Qing X, Guan L, Li HY, Qiao L, Chen YB, Cai YF, Wang Q, Zhang SJ. Carnosine improves cognitive impairment through promoting SIRT6 expression and inhibiting ER stress in a diabetic encephalopathy model. Rejuvenation Res 2022;25:79-88. [PMID: 35302398 DOI: 10.1089/rej.2022.0002] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/23/2022] Open

Abstract

Diabetic encephalopathy is one of complications of diabetes mellitus. Carnosine is a dipeptide composed of β-alanine and L-histidine. Study has shown that carnosine could ameliorate cognitive impairment in animal model with diabetes mellitus. However, the mechanism remains unclear. An animal model of type 2 diabetes (db/db mice) was used in this study. The animals were treated with 0.9 % saline or carnosine (100 mg/kg) for 8 weeks. Morris water maze was tested after drug administration. Oxidative stress-related factors malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-PX), and pro-inflammatory factors inducible nitric oxide synthase (iNOS) were measured. Synapse-related protein postsynapticdensity 95 (PSD95) and brain-derived neurotrophic factor (BDNF) were detected by western blot. Besides, the expressions of sirtuin 6 (SIRT6), binding immunoglobulin protein (BIP), protein kinase R-like endoplasmic reticulum kinase (PERK), phospho-protein kinase R-like endoplasmic reticulum kinase (P-PERK), inositol-requiring enzyme-1α (IRE1α), phospho-inositol-requiring enzyme-1α (P-IRE1α), activating transcription factor 6 (ATF6), C/EBP-homologous protein (CHOP) in the hippocampus of the brain were detected. The results showed that treatment with carnosine ameliorated cognitive impairment in db/db mice. Carnosine reduced neuronal oxidative stress damage and iNOS expression in db/db mice. Meanwhile, carnosine relieved neurodegeneration in the hippocampus of db/db mice. Furthermore, carnosine promoted the expression of SIRT6 and reduced the expressions of endoplasmic reticulum (ER) related factors (BIP, P-PERK, P-IRE1α, ATF6, CHOP). In conclusion, these data suggested that the protective effect of carnosine against diabetic encephalopathy might be related to SIRT6/ER stress pathway.

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Perestrelo BO, Carvalho PMD, Souza DN, Carneiro MJ, Cirino JPG, Carvalho PO, Sawaya ACHF, Oyama LM, Nogueira FN. Antioxidant effect of chamomile tea on the salivary glands of streptozotocin-induced diabetic rats. Braz Oral Res 2022;36:e034. [PMID: 35293499 DOI: 10.1590/1807-3107bor-2022.vol36.0034] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/24/2021] [Accepted: 11/03/2021] [Indexed: 01/13/2023] Open

El-Feky AM, Elbatanony MM, Aboul Naser AF, Younis EA, Hamed MA. Salvia hispanica L. seeds extract alleviate encephalopathy in streptozotocin-induced diabetes in rats: Role of oxidative stress, neurotransmitters, DNA and histological indices. Biomarkers 2022;27:427-440. [PMID: 35253573 DOI: 10.1080/1354750x.2022.2051072] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 02/08/2023]

S-nitrosoglutathione alleviates hyperglycemia-induced neurobehavioral deficits involving nitro-oxidative stress and aberrant monaminergic system. Nitric Oxide 2022;122-123:35-44. [DOI: 10.1016/j.niox.2022.03.001] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/23/2021] [Revised: 02/07/2022] [Accepted: 03/02/2022] [Indexed: 11/22/2022]

Mima A. Mitochondria-targeted drugs for diabetic kidney disease. Heliyon 2022;8:e08878. [PMID: 35265754 PMCID: PMC8899696 DOI: 10.1016/j.heliyon.2022.e08878] [Citation(s) in RCA: 47] [Impact Index Per Article: 15.7] [Reference Citation Analysis] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/01/2021] [Revised: 01/17/2022] [Accepted: 01/30/2022] [Indexed: 12/15/2022] Open

Ke K, Jiang X, Zhang Y, Zhou Y, Zhao J, Zhang J, Liu Y, An M. Exploring the Mechanism of Wu Ling San plus Flavor for the Treatment of Diabetic Macular Edema Based on Network Pharmacology and Molecular Docking Techniques. Chin Med 2022. [DOI: 10.4236/cm.2022.133004] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/20/2022] Open

Starace V, Battista M, Brambati M, Cavalleri M, Bertuzzi F, Amato A, Lattanzio R, Bandello F, Cicinelli MV. The role of inflammation and neurodegeneration in diabetic macular edema. Ther Adv Ophthalmol 2021;13:25158414211055963. [PMID: 34901746 PMCID: PMC8652911 DOI: 10.1177/25158414211055963] [Citation(s) in RCA: 14] [Impact Index Per Article: 3.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/09/2021] [Accepted: 10/08/2021] [Indexed: 12/14/2022] Open

Fakhlaei R, Selamat J, Razis AFA, Sukor R, Ahmad S, Amani Babadi A, Khatib A. In Vivo Toxicity Evaluation of Sugar Adulterated Heterotrigona itama Honey Using Zebrafish Model. Molecules 2021;26:molecules26206222. [PMID: 34684803 PMCID: PMC8538600 DOI: 10.3390/molecules26206222] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/05/2021] [Revised: 08/05/2021] [Accepted: 08/06/2021] [Indexed: 12/21/2022] Open

Abstract

Honey is prone to be adulterated through mixing with sugars, cheap and low-quality honey, and other adulterants. Consumption of adulterated honey may cause several health issues such as weight gain, diabetes, and liver and kidney dysfunction. Therefore, studying the impact of consumption of adulterated honey on consumers is critical since there is a lack of study in this field. Hence, the aims of this paper were: (1) to determine the lethal concentration (LC₅₀) of adulterated honey using zebrafish embryo, (2) to elucidate toxicology of selected adulterated honey based on lethal dose (LD₅₀) using adult zebrafish, (3) to determine the effects of adulterated honey on histological changes of zebrafish, and (4) to screen the metabolites profile of adulterated honey by using zebrafish blood serum. The LC₅₀ of Heterotrigona itama honey (acacia honey) and its sugar adulterants (light corn sugar, cane sugar, inverted sugar, and palm sugar in the proportion of 1-3% (w/w) from the total volume) was determined by the toxicological assessment of honey samples on zebrafish embryos (different exposure concentrations in 24, 48, 72, and 96 h postfertilization (hpf)). Pure H. itama honey represents the LC₅₀ of 34.40 ± 1.84 (mg/mL) at 96 hpf, while the inverted sugar represents the lowest LC₅₀ (5.03 ± 0.92 mg/mL) among sugar adulterants. The highest concentration (3%) of sugar adulterants were used to study the toxicology of adulterated honey using adult zebrafish in terms of acute, prolong-acute, and sub-acute tests. The results of the LD₅₀ from the sub-acute toxicity test of pure H. itama honey was 2.33 ± 0.24 (mg/mL). The histological studies of internal organs showed a lesion in the liver, kidney, and spleen of adulterated treated-honey groups compared to the control group. Furthermore, the LC-MS/MS results revealed three endogenous metabolites in both the pure and adulterated honey treated groups, as follows: (1) S-Cysteinosuccinic acid, (2) 2,3-Diphosphoglyceric acid, and (3) Cysteinyl-Tyrosine. The results of this study demonstrated that adulterated honey caused mortality, which contributes to higher toxicity, and also suggested that the zebrafish toxicity test could be a standard method for assessing the potential toxicity of other hazardous food additives. The information gained from this research will permit an evaluation of the potential risk associated with the consumption of adulterated compared to pure honey.

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