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Moreno-Gómez-Toledano R, Delgado-Marín M, Cook-Calvete A, González-Cucharero C, Alcharani N, Jiménez-Guirado B, Hernandez I, Ramirez-Carracedo R, Tesoro L, Botana L, Sánchez-Esteban S, Diez-Mata J, Zamorano JL, Bosch RJ, Zaragoza C, Saura M. New environmental factors related to diabetes risk in humans: Emerging bisphenols used in synthesis of plastics. World J Diabetes 2023; 14:1301-1313. [PMID: 37664470 PMCID: PMC10473949 DOI: 10.4239/wjd.v14.i8.1301] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/28/2023] [Revised: 05/21/2023] [Accepted: 06/05/2023] [Indexed: 08/11/2023] Open
Abstract
BACKGROUND Diabetes mellitus (DM) is one of the largest global health emergencies of the 21st century. In recent years, its connection with environmental pollutants, such as bisphenol A (BPA), has been demonstrated; consequently, new structurally similar molecules are used to replace BPA in the plastics industry (BPS, BPF and BPAF). AIM To carry out a systematic review to allow coherent evaluation of the state of the art. Subsequently, a meta-analysis was performed to unify the existing quantitative data. METHODS Firstly, a systematic review was carried out, using the terms "(bisphenol) AND (Diabetes OR Hyperglycemia)", to maximize the number of results. Subsequently, three authors analyzed the set of articles. Finally, a meta-analysis was performed for each BP, using RevMan software. In addition, funnel plots were developed to study publication bias. RESULTS The systematic analysis of the literature revealed 13 recent articles (2017-2023) related to the study paradigm. The qualitative analysis showed interesting data linking diabetes to the three most widely used substitute BPs in the industry: BPS, BPF and BPAF. Finally, the meta-analysis determined a positive relationship with BPS, BPF and BPAF, which was only statistically significant with BPS. CONCLUSION There is a need to apply the precautionary principle, regulating the use of new BPs. Therefore, replacing BPA with BPS, BPF or BPAF is unlikely to protect the population from potential health risks, such as DM.
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Affiliation(s)
- Rafael Moreno-Gómez-Toledano
- Universidad de Alcalá,Department of Biological Systems/Physiology, Alcalá de Henares 28871, Spain
- Cardiology Department, University Hospital Ramón y Cajal, Madrid 28034, Spain
- Laboratory of Cardiovascular Pathophysiology, Joint Translational Research Unit, University Francisco de Vitoria School of Medicine, Madrid 28034, Spain
- Instituto Ramón y Cajal de Investigación Sanitaria-IRYCIS, Madrid 28034, Spain
| | - María Delgado-Marín
- Universidad de Alcalá,Department of Biological Systems/Physiology, Alcalá de Henares 28871, Spain
| | - Alberto Cook-Calvete
- Universidad de Alcalá,Department of Biological Systems/Physiology, Alcalá de Henares 28871, Spain
| | - Claudia González-Cucharero
- Cardiology Department, University Hospital Ramón y Cajal, Madrid 28034, Spain
- Laboratory of Cardiovascular Pathophysiology, Joint Translational Research Unit, University Francisco de Vitoria School of Medicine, Madrid 28034, Spain
- Instituto Ramón y Cajal de Investigación Sanitaria-IRYCIS, Madrid 28034, Spain
| | - Nunzio Alcharani
- Cardiology Department, University Hospital Ramón y Cajal, Madrid 28034, Spain
- Laboratory of Cardiovascular Pathophysiology, Joint Translational Research Unit, University Francisco de Vitoria School of Medicine, Madrid 28034, Spain
- Instituto Ramón y Cajal de Investigación Sanitaria-IRYCIS, Madrid 28034, Spain
| | - Beatriz Jiménez-Guirado
- Cardiology Department, University Hospital Ramón y Cajal, Madrid 28034, Spain
- Laboratory of Cardiovascular Pathophysiology, Joint Translational Research Unit, University Francisco de Vitoria School of Medicine, Madrid 28034, Spain
- Instituto Ramón y Cajal de Investigación Sanitaria-IRYCIS, Madrid 28034, Spain
| | - Ignacio Hernandez
- Cardiology Department, University Hospital Ramón y Cajal, Madrid 28034, Spain
- Laboratory of Cardiovascular Pathophysiology, Joint Translational Research Unit, University Francisco de Vitoria School of Medicine, Madrid 28034, Spain
- Instituto Ramón y Cajal de Investigación Sanitaria-IRYCIS, Madrid 28034, Spain
| | - Rafael Ramirez-Carracedo
- Cardiology Department, University Hospital Ramón y Cajal, Madrid 28034, Spain
- Laboratory of Cardiovascular Pathophysiology, Joint Translational Research Unit, University Francisco de Vitoria School of Medicine, Madrid 28034, Spain
- Instituto Ramón y Cajal de Investigación Sanitaria-IRYCIS, Madrid 28034, Spain
| | - Laura Tesoro
- Cardiology Department, University Hospital Ramón y Cajal, Madrid 28034, Spain
- Laboratory of Cardiovascular Pathophysiology, Joint Translational Research Unit, University Francisco de Vitoria School of Medicine, Madrid 28034, Spain
- Instituto Ramón y Cajal de Investigación Sanitaria-IRYCIS, Madrid 28034, Spain
| | - Laura Botana
- Cardiology Department, University Hospital Ramón y Cajal, Madrid 28034, Spain
- Laboratory of Cardiovascular Pathophysiology, Joint Translational Research Unit, University Francisco de Vitoria School of Medicine, Madrid 28034, Spain
- Instituto Ramón y Cajal de Investigación Sanitaria-IRYCIS, Madrid 28034, Spain
| | - Sandra Sánchez-Esteban
- Universidad de Alcalá,Department of Biological Systems/Physiology, Alcalá de Henares 28871, Spain
| | - Javier Diez-Mata
- Cardiology Department, University Hospital Ramón y Cajal, Madrid 28034, Spain
- Laboratory of Cardiovascular Pathophysiology, Joint Translational Research Unit, University Francisco de Vitoria School of Medicine, Madrid 28034, Spain
- Instituto Ramón y Cajal de Investigación Sanitaria-IRYCIS, Madrid 28034, Spain
| | - Jose Luis Zamorano
- Cardiology Department, University Hospital Ramón y Cajal, Madrid 28034, Spain
- Instituto Ramón y Cajal de Investigación Sanitaria-IRYCIS, Madrid 28034, Spain
| | - Ricardo J. Bosch
- Universidad de Alcalá,Department of Biological Systems/Physiology, Alcalá de Henares 28871, Spain
| | - Carlos Zaragoza
- Cardiology Department, University Hospital Ramón y Cajal, Madrid 28034, Spain
- Laboratory of Cardiovascular Pathophysiology, Joint Translational Research Unit, University Francisco de Vitoria School of Medicine, Madrid 28034, Spain
- Instituto Ramón y Cajal de Investigación Sanitaria-IRYCIS, Madrid 28034, Spain
| | - Marta Saura
- Universidad de Alcalá,Department of Biological Systems/Physiology, Alcalá de Henares 28871, Spain
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Chkhitauri L, Sanikidze T, Giorgadze E, Asatiani K, Kipiani N, Momtselidze N, Mantskava M. Comprehensive study of the rheological status and intensity of oxidative stress during the progression of type 2 diabetes mellitus to prevent its complications. Clin Hemorheol Microcirc 2022; 83:69-79. [PMID: 36120773 DOI: 10.3233/ch-221512] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/15/2022]
Abstract
BACKGROUND Prevention of Type 2 diabetes mellitus (T2DM) requires a modifying effect on the pathological processes inducing the β-cell dysfunction. OBJECTIVES the comprehensive study of the violation of rheological parameters in patients with different stages of diabetes and identification of possible links between these alterations with the intensity of the oxidative stress in the patient's body. METHODS 60 patients with IR, prediabetes, T2DM and healthy volunteers were included. Full range of the rheological parameters of the patients' blood - the indicators of erythrocytes aggregation index (EAI), the relative deformability of the erythrocytes membranes (ERDI), blood plasma viscosity (BPV), and oxidative stress intensity (OSI) were examined. RESULTS In patients with insulin resistance (IR), prediabetes, and T2DM the ERDI was statistically significantly lower and BPV - higher compared to control; a significant increase in EAI was detected in the patient group with prediabetes and T2DM compared to the control. CONCLUSION The level of rheological disorders in patients increases with the increase of the level of carbohydrate metabolism disorders and intensity of oxidative stress and reaches a maximum during manifested diabetes. Diagnosis of hemorheological disorders and OSI in T2DM can serve as an early marker of target organ damage possibility.
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Affiliation(s)
- Lela Chkhitauri
- Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia
| | - Tamar Sanikidze
- Tbilisi State Medical University, Tbilisi, Georgia.,Ivane Beritashvili Experimental Center of Biomedicine, Tbilisi, Georgia
| | - Elene Giorgadze
- Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia
| | | | - Nana Kipiani
- Tbilisi State Medical University, Tbilisi, Georgia
| | - Nana Momtselidze
- Ivane Beritashvili Experimental Center of Biomedicine, Tbilisi, Georgia.,Multidisciplinary Science High School, Tbilisi, Georgia.,UNIK-Kutaisi University, Kutaisi, Georgia
| | - Maka Mantskava
- Tbilisi State Medical University, Tbilisi, Georgia.,Ivane Beritashvili Experimental Center of Biomedicine, Tbilisi, Georgia.,Multidisciplinary Science High School, Tbilisi, Georgia.,European University, Tbilisi, Georgia
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A computational study of red blood cell deformability effect on hemodynamic alteration in capillary vessel networks. Sci Rep 2022; 12:4304. [PMID: 35277592 PMCID: PMC8917159 DOI: 10.1038/s41598-022-08357-z] [Citation(s) in RCA: 24] [Impact Index Per Article: 8.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/06/2021] [Accepted: 03/07/2022] [Indexed: 01/12/2023] Open
Abstract
Capillary blood vessels, the smallest vessels in the body, form an intricate network with constantly bifurcating, merging and winding vessels. Red blood cells (RBCs) must navigate through such complex microvascular networks in order to maintain tissue perfusion and oxygenation. Normal, healthy RBCs are extremely deformable and able to easily flow through narrow vessels. However, RBC deformability is reduced in many pathological conditions and during blood storage. The influence of reduced cell deformability on microvascular hemodynamics is not well established. Here we use a high-fidelity, 3D computational model of blood flow that retains exact geometric details of physiologically realistic microvascular networks, and deformation of every one of nearly a thousand RBCs flowing through the networks. We predict that reduced RBC deformability alters RBC trafficking with significant and heterogeneous changes in hematocrit. We quantify such changes along with RBC partitioning and lingering at vascular bifurcations, perfusion and vascular resistance, and wall shear stress. We elucidate the cellular-scale mechanisms that cause such changes. We show that such changes arise primarily due to the altered RBC dynamics at vascular bifurcations, as well as cross-stream migration. Less deformable cells tend to linger less at majority of bifurcations increasing the fraction of RBCs entering the higher flow branches. Changes in vascular resistance also seen to be heterogeneous and correlate with hematocrit changes. Furthermore, alteration in RBC dynamics is shown to cause localized changes in wall shear stress within vessels and near vascular bifurcations. Such heterogeneous and focal changes in hemodynamics may be the cause of morphological abnormalities in capillary vessel networks as observed in several diseases.
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Khazaei M, Fallahzadeh AR, Sharifi MR, Afsharmoghaddam N, Javanmard SH, Salehi E. Effects of diabetes on myocardial capillary density and serum angiogenesis biomarkers in male rats. Clinics (Sao Paulo) 2011; 66:1419-24. [PMID: 21915494 PMCID: PMC3161222 DOI: 10.1590/s1807-59322011000800019] [Citation(s) in RCA: 30] [Impact Index Per Article: 2.1] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/23/2010] [Accepted: 04/26/2011] [Indexed: 01/10/2023] Open
Abstract
INTRODUCTION Cardiovascular disease is one of the main causes of mortality and morbidity in diabetic patients. This study evaluated the effects of diabetes on myocardial capillary density and several serum angiogenic factors including nitric oxide, vascular endothelial growth factor, and soluble vascular endothelial growth factor receptors. METHODS Twelve male rats were divided into two groups: control and diabetic (n = 6 each). Diabetes was induced with a single dose of streptozotocin (50 mg/kg). After 21 days, capillary density in the myocardial tissue was evaluated using immunohistochemical staining and is reported as capillaries per mm². Blood samples were collected before and after the induction of diabetes. RESULTS In the diabetic group, serum nitric oxide and soluble vascular endothelial growth factor receptor 2 concentrations were lower than the levels in the control group, while the level of soluble vascular endothelial growth factor receptor 1 was significantly higher. There was no significant change in the serum vascular endothelial growth factor concentration between the diabetic and control groups; however, the ratio of vascular endothelial growth factor to vascular endothelial growth factor receptor 1 was significantly lower in the diabetic animals. The myocardial capillary density was also lower in the diabetic group compared with the control group (1549 ± 161 vs. 2156 ± 202/mm², respectively). CONCLUSION Reduced serum nitric oxide and vascular endothelial growth factor receptor 2 levels, increased serum vascular endothelial growth factor receptor 1 levels and a lower vascular endothelial growth factor to vascular endothelial growth factor receptor 1 ratio may be responsible for the decreased myocardial capillary density in diabetic rats.
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Affiliation(s)
- Majid Khazaei
- Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
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Khazaei M, Moien-Afshari F, Laher I. Vascular endothelial function in health and diseases. ACTA ACUST UNITED AC 2008; 15:49-67. [PMID: 18434105 DOI: 10.1016/j.pathophys.2008.02.002] [Citation(s) in RCA: 64] [Impact Index Per Article: 3.8] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/16/2007] [Revised: 02/07/2008] [Accepted: 02/08/2008] [Indexed: 11/30/2022]
Abstract
The vascular endothelium constitutes approximately 1% of body mass (1kg) and has a surface area of approximately 5000m(2). The endothelium is a multifunctional endocrine organ strategically placed between the vessel wall and the circulating blood, and has a key role in vascular homeostasis. The endothelium is both a target for and mediator of cardiovascular disease. The endothelium releases several relaxing and constricting factors, which can affect vascular homeostasis. Endothelial dysfunction, whether caused by physical injury or cellular damage, leads to compensatory responses that alter the normal homeostatic properties of the endothelium. In this review, we summarized some physiological aspects of endothelial function and then we discussed endothelial dysfunction during some pathological conditions.
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Affiliation(s)
- M Khazaei
- Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
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