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For: Amberger JS, Bocchini CA, Schiettecatte F, Scott AF, Hamosh A. OMIM.org: Online Mendelian Inheritance in Man (OMIM®), an online catalog of human genes and genetic disorders. Nucleic Acids Res 2014;43:D789-98. [PMID: 25428349 PMCID: PMC4383985 DOI: 10.1093/nar/gku1205] [Citation(s) in RCA: 1661] [Impact Index Per Article: 151.0] [Reference Citation Analysis] [What about the content of this article? (0)] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/15/2022]  Open
Number Cited by Other Article(s)
1
Ak B, Akısü M, Durmaz A, Yalaz M, Terek D, Sönmezler E, Oktay Y, Akın H, Aykut A. Expanding the genetic spectrum of short rib polydactyly syndrome: Novel DYNC2H1 variants and functional insights. Bone 2025;197:117511. [PMID: 40339774 DOI: 10.1016/j.bone.2025.117511] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/11/2025] [Revised: 04/28/2025] [Accepted: 05/02/2025] [Indexed: 05/10/2025]
2
Ghanty I, Perez-Palma E, Villaman C, Stobo D, Symonds J, Zuberi S, Lal D, Brunklaus A. SCN9A should not be considered an epilepsy gene; Refuting a gene-disease association. Epilepsia 2025. [PMID: 40492992 DOI: 10.1111/epi.18474] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/23/2025] [Revised: 05/11/2025] [Accepted: 05/12/2025] [Indexed: 06/12/2025]
3
Wen B, Shi S, Long Y, Dang Y, Tian W. PhenoDP: leveraging deep learning for phenotype-based case reporting, disease ranking, and symptom recommendation. Genome Med 2025;17:67. [PMID: 40481598 PMCID: PMC12143081 DOI: 10.1186/s13073-025-01496-8] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/07/2024] [Accepted: 05/27/2025] [Indexed: 06/11/2025]  Open
4
Zhang M, Qiu H, Han Z, Ma Y, Hou J, Yuan J, Jia H, Zhou M, Lu H, Wu Y. Topical transdermal administration of lenalidomide nanosuspensions-based hydrogels against melanoma: In vitro and in vivo studies. Int J Pharm X 2025;9:100316. [PMID: 39898009 PMCID: PMC11787432 DOI: 10.1016/j.ijpx.2025.100316] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/27/2024] [Revised: 01/09/2025] [Accepted: 01/13/2025] [Indexed: 02/04/2025]  Open
5
Gholami M, Hamidi AK, Naghshband Z, Asadi M, Amoli MM. Whole exome sequencing revealed new variants and haplotypes associated with monogenic obesity. J Diabetes Metab Disord 2025;24:23. [PMID: 39712340 PMCID: PMC11662120 DOI: 10.1007/s40200-024-01507-2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/26/2024] [Accepted: 12/01/2024] [Indexed: 12/24/2024]
6
Sun P, Song J, Liu Y, Li X, Zhang Y, Zhou Y, Gong W. Investigating the Mechanisms of Lycii fructus in Treating Nonalcoholic Fatty Liver Disease and Diabetes Comorbidity Through Network Pharmacology and Molecular Dynamics. Food Sci Nutr 2025;13:e70256. [PMID: 40433113 PMCID: PMC12106045 DOI: 10.1002/fsn3.70256] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/22/2024] [Revised: 02/27/2025] [Accepted: 04/25/2025] [Indexed: 05/29/2025]  Open
7
Yang Y, Yu K, Gao S, Yu S, Xiong D, Qin C, Chen H, Tang J, Tang N, Zhu H. Alzheimer's disease knowledge graph enhances knowledge discovery and disease prediction. Comput Biol Med 2025;192:110285. [PMID: 40306017 PMCID: PMC12103266 DOI: 10.1016/j.compbiomed.2025.110285] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/27/2024] [Revised: 03/26/2025] [Accepted: 04/24/2025] [Indexed: 05/02/2025]
8
Cao Q, Cai C, Wang C, Li L, Liu J, Zhang J, Rong M, Ren J, Han Y, Zhang J, Han X. Zengmian Yiliu formula suppresses cell cycle in immune-rich ovarian cancer patient-derived organoids. PHYTOMEDICINE : INTERNATIONAL JOURNAL OF PHYTOTHERAPY AND PHYTOPHARMACOLOGY 2025;141:156721. [PMID: 40215819 DOI: 10.1016/j.phymed.2025.156721] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 10/10/2024] [Revised: 03/18/2025] [Accepted: 04/01/2025] [Indexed: 04/29/2025]
9
Marques JP, Soares CA, Carvalho AL, Estrela‐Silva S, Santos LC, Ramos L, Silva E. Portuguese Society of Ophthalmology and Portuguese Society of Human Genetics Joint Clinical Practice Guidelines for Genetic Testing in Inherited Retinal Dystrophies. Clin Genet 2025;107:600-611. [PMID: 39745089 PMCID: PMC12050251 DOI: 10.1111/cge.14691] [Citation(s) in RCA: 1] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/25/2024] [Revised: 11/30/2024] [Accepted: 12/18/2024] [Indexed: 05/06/2025]
10
He J, Wong LY, Chen S, Zhang SJ, Chen W, Bai JX, Wang L, Wang XQ, Li SMA, Li Q, Fu XQ, Yu ZL. Inhibition of the PI3K/AKT signaling pathway contributes to the anti-renal cell carcinoma effects of deoxyelephantopin. Biomed Pharmacother 2025;187:118136. [PMID: 40344699 DOI: 10.1016/j.biopha.2025.118136] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/05/2025] [Revised: 04/17/2025] [Accepted: 05/05/2025] [Indexed: 05/11/2025]  Open
11
Honarmand H, Bonyadi M, Barzegar M. Genetic insights into progressive myoclonic epilepsies: A case study of KCTD7 mutation in an Iranian-Azeri-Turkish family. Epilepsy Behav Rep 2025;30:100757. [PMID: 40123863 PMCID: PMC11925558 DOI: 10.1016/j.ebr.2025.100757] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/29/2024] [Revised: 02/25/2025] [Accepted: 02/26/2025] [Indexed: 03/25/2025]  Open
12
Li X, Liu X, Cai M, Wei S, Wang R, Xu N, Qu J, Wang Y. Investigation of the mechanism of Dan Zhi Qing'e Formula for treating menopausal hot flashes using UHPLC-Q-TOF MS and network pharmacology. NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY 2025:10.1007/s00210-025-04277-7. [PMID: 40434420 DOI: 10.1007/s00210-025-04277-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 11/13/2024] [Accepted: 05/07/2025] [Indexed: 05/29/2025]
13
Li X, Chen M, Wei D, Wei P, Jiang Y, Chen J, Duan X, Wang Z, Zhang Y, Bai D, Jia H, Jin G. Study on the Mechanism of Dihydromyricetin in Alleviating Depressive-Like Behavior in Rats Based on Network Pharmacology. Neurochem Res 2025;50:171. [PMID: 40418429 DOI: 10.1007/s11064-025-04419-6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/27/2024] [Revised: 05/01/2025] [Accepted: 05/05/2025] [Indexed: 05/27/2025]
14
Bellaart A, Brambila A, Xu J, Mendez Diaz F, Deep A, Anzola J, Meitinger F, Ohta M, Corbett KD, Desai A, Oegema K. TRIM37 prevents ectopic spindle pole assembly by peptide motif recognition and substrate-dependent oligomerization. Nat Struct Mol Biol 2025:10.1038/s41594-025-01562-0. [PMID: 40415024 DOI: 10.1038/s41594-025-01562-0] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/17/2024] [Accepted: 04/10/2025] [Indexed: 05/27/2025]
15
Xiu J, Yang H, Shen X, Xing Y, Li W, Han W. Exploring Hidden Dangers: Predicting Mycotoxin-like Toxicity and Mapping Toxicological Networks in Hepatocellular Carcinoma. J Chem Inf Model 2025. [PMID: 40393043 DOI: 10.1021/acs.jcim.5c00171] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 05/22/2025]
16
Sharma Y, Good DJ. Case Study: Genetic and In Silico Analysis of Familial Pancreatitis. Genes (Basel) 2025;16:603. [PMID: 40428425 PMCID: PMC12110861 DOI: 10.3390/genes16050603] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/28/2025] [Revised: 05/12/2025] [Accepted: 05/13/2025] [Indexed: 05/29/2025]  Open
17
Sun C, Gao X, Sha S, Wang S, Shan Y, Li L, Xing C, Guan H, Du H. Berberine alleviates Alzheimer's disease by activating autophagy and inhibiting ferroptosis through the JNK-p38MAPK signaling pathway. Int Immunopharmacol 2025;155:114550. [PMID: 40215776 DOI: 10.1016/j.intimp.2025.114550] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/12/2024] [Revised: 03/19/2025] [Accepted: 03/22/2025] [Indexed: 04/29/2025]
18
Lv Q, Chen L, Du Y, Yang P, Chen Q, Qin F, Zhang H, Li Y. Network pharmacology and in vitro experiments based strategy to explore the effects of Jujuboside A on the proliferation and migration ability of glioma cells. Brain Res 2025;1855:149570. [PMID: 40090447 DOI: 10.1016/j.brainres.2025.149570] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/22/2024] [Revised: 03/06/2025] [Accepted: 03/10/2025] [Indexed: 03/18/2025]
19
Yang F, Luo G, Liu MN, Liu P, Wu D, Chen HL, Li S, Yang SJ, Dong L. Network pharmacology and experimental validation to investigate the mechanism of action of Zhilong Huoxue Tongyu capsule in the prevention and treatment of diabetic cardiomyopathy. PLoS One 2025;20:e0323745. [PMID: 40373162 DOI: 10.1371/journal.pone.0323745] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/23/2024] [Accepted: 04/12/2025] [Indexed: 05/17/2025]  Open
20
Zhang Q, Yang L, Li C, Zhang Y, Li R, Jia F, Wang L, Ma X, Yao K, Tian H, Zhuo C. Exploring the potential antidepressant mechanisms of ibuprofen and celecoxib based on network pharmacology and molecular docking. J Affect Disord 2025;377:136-147. [PMID: 39986574 DOI: 10.1016/j.jad.2025.02.053] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/18/2024] [Revised: 02/07/2025] [Accepted: 02/17/2025] [Indexed: 02/24/2025]
21
Sun H, Hao X, Liu H, Zhang S, Han J, Zhang Y, Liu T, Yang X, Wang H, Fan J, Guan Y, Peng N, Xie J, Xia H, Ji X, Xu Y, Zhang J, Wang J, Lan F, Zhang H, Gu X, He Y. Rare damaging variants in the sex differences of congenital heart disease: an exome sequencing study. EBioMedicine 2025;116:105736. [PMID: 40347836 DOI: 10.1016/j.ebiom.2025.105736] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/19/2024] [Revised: 04/14/2025] [Accepted: 04/15/2025] [Indexed: 05/14/2025]  Open
22
Eisfeldt J, Ek M, Nordenskjöld M, Lindstrand A. Toward clinical long-read genome sequencing for rare diseases. Nat Genet 2025:10.1038/s41588-025-02160-y. [PMID: 40335760 DOI: 10.1038/s41588-025-02160-y] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/15/2024] [Accepted: 03/11/2025] [Indexed: 05/09/2025]
23
Fortunato F, De Fiores R, Sammarra I, Bonacci MC, Caligiuri ME, Sturniolo M, Martino I, Gambardella A. Focal epilepsy with sensory seizures associated with arginine:glycine amidinotransferase deficiency: A clinical and advanced magnetic resonance imaging study. Epilepsia 2025. [PMID: 40323733 DOI: 10.1111/epi.18442] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/17/2025] [Revised: 04/18/2025] [Accepted: 04/21/2025] [Indexed: 05/07/2025]
24
Qi J, Wang Y, Chen H, Wu K, Zhou P, Dou Y, Xiong B, Zhou W. Advancing the Identification of Bioactive Molecules and the Construction of a Synergistic Drug Delivery System in Combating Lung Injury. ADVANCED SCIENCE (WEINHEIM, BADEN-WURTTEMBERG, GERMANY) 2025;12:e2407802. [PMID: 40091443 PMCID: PMC12079430 DOI: 10.1002/advs.202407802] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 07/11/2024] [Revised: 02/17/2025] [Indexed: 03/19/2025]
25
He H, Jin X, Ding X, Jiang H, Wang X, Chen Y, Zhu J. Unraveling the Anti-Tumor Effects and Molecular Mechanisms of Hairyvein Agrimonia Herb in Gastric Cancer Through Network Pharmacology and Experimental Validation. Cancer Rep (Hoboken) 2025;8:e70169. [PMID: 40391580 PMCID: PMC12089993 DOI: 10.1002/cnr2.70169] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/08/2024] [Revised: 12/24/2024] [Accepted: 02/14/2025] [Indexed: 05/22/2025]  Open
26
Radjasandirane R, Diharce J, Gelly JC, de Brevern AG. Insights for variant clinical interpretation based on a benchmark of 65 variant effect predictors. Genomics 2025;117:111036. [PMID: 40127826 DOI: 10.1016/j.ygeno.2025.111036] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/05/2024] [Revised: 02/20/2025] [Accepted: 03/20/2025] [Indexed: 03/26/2025]
27
Pandey H, Sharma J, Kumar S, Mohan N, Jain V, Dhua AK, Yadav DK, Dubey AK, Choudhury P, Goel P. Chromosomal Microarray Analysis in Spina Bifida: Genetic Heterogeneity and Its Clinical Implications. J Indian Assoc Pediatr Surg 2025;30:290-295. [PMID: 40406313 PMCID: PMC12094595 DOI: 10.4103/jiaps.jiaps_217_24] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/20/2024] [Revised: 11/26/2024] [Accepted: 12/10/2024] [Indexed: 05/26/2025]  Open
28
Yan Z, Zhang L, Ma T, Yuan Y, Kang Y, Liu S, Chen B, Li K, Xiao M, Xie Y. SuoquanYishen formula improves renal cellular senescence by inhibiting YTHDF1-Rubicon axis to promote autophagy in diabetic kidney disease. Front Pharmacol 2025;16:1543277. [PMID: 40371338 PMCID: PMC12075247 DOI: 10.3389/fphar.2025.1543277] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/11/2024] [Accepted: 04/14/2025] [Indexed: 05/16/2025]  Open
29
Hong J, Guo Z, Huang X, Wu P, Chen X, Liu X, Yang J, Lai Y. Pharmacological mechanisms of probenecid for SARS-CoV-2 and RSV co-infection: findings of system pharmacology, molecular docking, molecular dynamics simulation, and structure-activity relationship. Front Microbiol 2025;16:1552603. [PMID: 40371107 PMCID: PMC12075369 DOI: 10.3389/fmicb.2025.1552603] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/28/2025] [Accepted: 04/10/2025] [Indexed: 05/16/2025]  Open
30
Lu Q, Tian W, Cheng Y, Chen Z, Cao Y, Zhao H, Tong Z, Chang Y, Zhou Y. Metabolomics and network pharmacology reveal the anti-inflammatory core substances and mechanisms of a new cultivar of high-polyphenol lettuce. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE 2025. [PMID: 40298069 DOI: 10.1002/jsfa.14270] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 09/12/2024] [Revised: 02/13/2025] [Accepted: 03/19/2025] [Indexed: 04/30/2025]
31
Niu Q, Zhang T. Synergistic mechanism of olaparib and cisplatin on breast cancer elucidated by network pharmacology. Sci Rep 2025;15:14800. [PMID: 40295796 PMCID: PMC12038030 DOI: 10.1038/s41598-025-99741-y] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/02/2024] [Accepted: 04/22/2025] [Indexed: 04/30/2025]  Open
32
Bai T, Hu Y, Zhou J, Luo L, Liu Y, Yu C. Therapeutic effects and potential mechanisms of caffeine on obese polycystic ovary syndrome: bioinformatic analysis and experimental validation. Sci Rep 2025;15:14640. [PMID: 40287474 PMCID: PMC12033246 DOI: 10.1038/s41598-025-93890-w] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/15/2024] [Accepted: 03/10/2025] [Indexed: 04/29/2025]  Open
33
Wang C, Huang W, Chen Q, Yang C, Zhu H, Chen X, He Q, Yu X. Exploring the mechanism of Cynanchum paniculatum (Bunge) Kitag's therapeutic strategy for rheumatoid arthritis: integrating network pharmacology, molecular docking and in vivo experiments. J Biomol Struct Dyn 2025:1-15. [PMID: 40269643 DOI: 10.1080/07391102.2025.2494840] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/16/2023] [Accepted: 04/04/2024] [Indexed: 04/25/2025]
34
Shen YZ, Luo B, Zhang Q, Hu L, Hu YC, Chen MH. Exploration potential sepsis-ferroptosis mechanisms through the use of CETSA technology and network pharmacology. Sci Rep 2025;15:13527. [PMID: 40253433 PMCID: PMC12009306 DOI: 10.1038/s41598-025-95451-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/26/2024] [Accepted: 03/20/2025] [Indexed: 04/21/2025]  Open
35
Li H, Hu H, Huang X, Zhang J, Che L, Li X, Bagen H, Qiqige W, Guleng W, Tong H. Investigating the mechanism of action of the Mongolian Medicine Areca Thirteen Pill (GY-13) in treating major depressive disorder based on integrated pharmacology. Medicine (Baltimore) 2025;104:e42217. [PMID: 40258735 PMCID: PMC12014044 DOI: 10.1097/md.0000000000042217] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/03/2025] [Accepted: 04/04/2025] [Indexed: 04/23/2025]  Open
36
Lei S, Wu Q, Zhang B, Lu M, Xia Y, Li N. Liver-Targeting Nanoparticles GA-MSe@AR Treat NAFLD Through Dual Lipid-Lowering and Antioxidant Efficacy. Int J Nanomedicine 2025;20:5017-5037. [PMID: 40271147 PMCID: PMC12015739 DOI: 10.2147/ijn.s510577] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/05/2024] [Accepted: 04/04/2025] [Indexed: 04/25/2025]  Open
37
Zhao Q, Dong G, Zhang X, Gao X, Li H, Guo Z, Gong L, Yang H. Unraveling the mechanism of core prescription in primary liver cancer: integrative analysis through data mining, network pharmacology, and molecular simulation. In Silico Pharmacol 2025;13:63. [PMID: 40255256 PMCID: PMC12003234 DOI: 10.1007/s40203-025-00352-2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/11/2024] [Accepted: 03/31/2025] [Indexed: 04/22/2025]  Open
38
Chakraborty A, Devarajan A, Kumar K, C S R, Madhusudhan MS, Ratnaparkhi GS, Kamat SS. Bioinformatics Analysis Identifies Sequence Determinants of Enzymatic Activity for the PHARC-Associated Lipase ABHD12. Biochemistry 2025;64:1852-1863. [PMID: 40138185 DOI: 10.1021/acs.biochem.4c00865] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 03/29/2025]
39
Oh KK, Yoon SJ, Eom JA, Lee KJ, Kwon GH, Kim DJ, Suk KT. The assembled decoders to prepare for "bioactive X″ against progressive deterioration of liver disease: From NAFLD to HCC. Eur J Med Chem 2025;288:117385. [PMID: 39970728 DOI: 10.1016/j.ejmech.2025.117385] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/20/2024] [Revised: 01/07/2025] [Accepted: 01/30/2025] [Indexed: 02/21/2025]
40
Chen T, Lv D, Rong B, Shi Z, Li X, Jia Z, Gao Z, Zhong C. Phytochemical characterization and therapeutic mechanism of Xialiqi capsule on benign prostatic hyperplasia. NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY 2025:10.1007/s00210-025-04108-9. [PMID: 40223034 DOI: 10.1007/s00210-025-04108-9] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 10/31/2024] [Accepted: 03/25/2025] [Indexed: 04/15/2025]
41
Chen Q, Hu Q, Zhang F, Lu W, Yuan Z, Qiao F. Mechanistic evaluation of Jiu Wei Qing Zhi Gao in non-alcoholic fatty liver disease: insights from network Pharmacology and experimental validation. Hereditas 2025;162:59. [PMID: 40221773 PMCID: PMC11992867 DOI: 10.1186/s41065-025-00427-2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/28/2025] [Accepted: 03/31/2025] [Indexed: 04/14/2025]  Open
42
Ma J, Wei P, Xu X, Dong R, Deng X, Zhang F, Sun M, Li M, Liu W, Yao J, Cao Y, Ying L, Yang Y, Yang Y, Wu X, She G. Machine learning-assisted analysis of serum metabolomics and network pharmacology reveals the effective compound from herbal formula against alcoholic liver injury. Chin Med 2025;20:48. [PMID: 40217538 PMCID: PMC11992827 DOI: 10.1186/s13020-025-01094-1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/14/2024] [Accepted: 03/09/2025] [Indexed: 04/14/2025]  Open
43
Zhang J, Deng L, Deng L. Protein structural domain-disease association prediction based on heterogeneous networks. BMC Genomics 2025;23:869. [PMID: 40211147 PMCID: PMC11987217 DOI: 10.1186/s12864-024-11117-0] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/01/2021] [Accepted: 12/02/2024] [Indexed: 04/12/2025]  Open
44
Ogloblinsky MSC, Conrad DF, Baudot A, Tournier-Lasserve E, Génin E, Marenne G. Benchmark of computational methods to detect digenism in sequencing data. Eur J Hum Genet 2025:10.1038/s41431-025-01834-9. [PMID: 40204980 DOI: 10.1038/s41431-025-01834-9] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/22/2024] [Revised: 03/06/2025] [Accepted: 03/11/2025] [Indexed: 04/11/2025]  Open
45
Hu SJ, Chen GC, Wang FY, Fang YQ, Wang SQ, Song ZL, Zhao ZH, Zhang QL, Meng XY, Zhang QY, Qin LP. Network pharmacology analysis uncovers the mechanism of Shudihuang-Shanzhuyu herb pair in prevention and treatment of diabetic osteoporosis via PI3K/AKT pathway. JOURNAL OF ETHNOPHARMACOLOGY 2025;345:119581. [PMID: 40054640 DOI: 10.1016/j.jep.2025.119581] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 12/04/2024] [Revised: 02/15/2025] [Accepted: 03/02/2025] [Indexed: 03/29/2025]
46
Özkaya Gül S, Şimşek B, Yıldız F, Aydemir E. Cytotoxic Effect of Escitalopram/Etoposide Combination on Etoposide-Resistant Lung Cancer. Pharmaceuticals (Basel) 2025;18:531. [PMID: 40283966 PMCID: PMC12030030 DOI: 10.3390/ph18040531] [Citation(s) in RCA: 1] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/05/2025] [Revised: 03/26/2025] [Accepted: 03/30/2025] [Indexed: 04/29/2025]  Open
47
Chowdhury MR, Reddy RVS, Nampoothiri NK, Erva RR, Vijaykumar SD. Exploring bioactive natural products for treating neurodegenerative diseases: a computational network medicine approach targeting the estrogen signaling pathway in amyotrophic lateral sclerosis and Parkinson's disease. Metab Brain Dis 2025;40:169. [PMID: 40184012 DOI: 10.1007/s11011-025-01585-y] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/08/2024] [Accepted: 03/17/2025] [Indexed: 04/05/2025]
48
Li K, Zhang Y, Diao Y, Fan S. Paeonol regulates the DDIT4-mTOR signaling pathway in macrophages to promote diabetic wound healing. Int Immunopharmacol 2025;151:114347. [PMID: 39987633 DOI: 10.1016/j.intimp.2025.114347] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/22/2025] [Revised: 02/18/2025] [Accepted: 02/19/2025] [Indexed: 02/25/2025]
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Chen J, Wen F, Zhou J, Tan M. Evaluating the Mechanism Underlying Multi-Compound Synergy of Banxia Decoction in the Treatment of Hashimoto's Thyroiditis Based on Network Pharmacology and Molecular Docking. Int J Gen Med 2025;18:1887-1902. [PMID: 40196382 PMCID: PMC11972970 DOI: 10.2147/ijgm.s502321] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/14/2024] [Accepted: 03/09/2025] [Indexed: 04/09/2025]  Open
50
Hu W, Wang H, Gan L, Lin Y, Fu Y, Tan W, Dou X, Ye L. Sulfonation of Capsaicin by sulfotransferases produces an anti-inflammatory metabolite with NF-κB pathway modulatory activity. Fitoterapia 2025;182:106463. [PMID: 40090597 DOI: 10.1016/j.fitote.2025.106463] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/17/2024] [Revised: 02/26/2025] [Accepted: 03/04/2025] [Indexed: 03/18/2025]
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