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Prabahar K, Ravikumar A, Jeyabalan AP, Ravi B, Ravikumar C, PannirukaiSelvan N, Alqifari SF, Sivaraman V, Shanmugasundaram N, Sankar K. Agomelatine with cognitive behavioral therapy reduces insomnia severity index and subjective units of distress scores than initial-dose clonazepam in moderate to severe insomnia patients: A quasi-experimental study. Pharmacol Biochem Behav 2025; 251:174003. [PMID: 40157395 DOI: 10.1016/j.pbb.2025.174003] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/10/2025] [Revised: 03/25/2025] [Accepted: 03/26/2025] [Indexed: 04/01/2025]
Abstract
BACKGROUND Insomnia can be caused by various factors including lack of sleep, stress, sadness, hormonal changes, excessive caffeine, anxiety, mental health disorders, and medications. Treatments include finding the cause, improving sleep patterns, using behavioral therapy, and taking sleeping pills in most cases. However, the drugs often cause worse side effects than insomnia. This study compared the efficacy of initial agomelatine and clonazepam doses with cognitive behavioral therapy for insomnia (CBT-i) in moderate to severe insomnia patients. METHODS This quasi-experiment study involved 230 moderate to severe insomnia patients with group A as clonazepam 0.25 mg and B as agomelatine 25 mg. CBT-i was received by both of the groups and the Insomnia Severity Index (ISI), Subjective Units of Distress Scale (SUDS) score, medication adherence, and Adverse Drug Reactions (ADRs) were followed for up to 24 weeks. RESULTS In the comparative analysis between and within groups, group B exhibited a significant reduction in ISI (p = 0.001) and SUDS (p = 0.001) scores at week 24 compared to group A. Overall, both groups demonstrated improved adherence. However, 12 patients in group A and 10 in group B experienced ADR, which included drowsiness, hypersalivation, diarrhea, maculopapular rash, and myotoxicity. The clonazepam-treated group showed reduced efficacy from week 12 onwards in the ISI and from week 16 in the SUDS median score, which was not observed in the agomelatine group. CONCLUSION The initial dose of agomelatine with CBT-i has a better impact on improving moderate to severe insomnia than the initial dose of clonazepam with CBT-i.
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Affiliation(s)
- Kousalya Prabahar
- Department of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia
| | - Abinaya Ravikumar
- Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Tamilnadu, India
| | - Anu Priya Jeyabalan
- Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Tamilnadu, India
| | - Bharath Ravi
- Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Tamilnadu, India
| | - Chandini Ravikumar
- Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Tamilnadu, India
| | - Nithishadevi PannirukaiSelvan
- Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Tamilnadu, India
| | - Saleh F Alqifari
- Department of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia
| | - Varadharajan Sivaraman
- Department of Clinical Psychology, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Tamilnadu, India
| | - Natarajan Shanmugasundaram
- Department of Psychiatry, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra Institute of Higher Education and Research, Chennai 600 116, Tamil Nadu, India
| | - Karthik Sankar
- Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Tamilnadu, India.
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Zhang N, Wu X, Cui N, Shao Y, Zhang Y. Short-term recovery sleep attenuates the impairment of response inhibition after total sleep deprivation: Evidence from an event-related potentials study. Int J Psychophysiol 2025; 212:112563. [PMID: 40204200 DOI: 10.1016/j.ijpsycho.2025.112563] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/09/2024] [Revised: 03/31/2025] [Accepted: 04/05/2025] [Indexed: 04/11/2025]
Abstract
OBJECTIVES Sleep deprivation is increasingly a problem in modern society. Therefore, understanding the restorative effects of short naps on cognitive function after sleep deprivation has considerable relevance. This study investigated changes in response inhibition function after 30 h of total sleep deprivation (TSD) and the impact of 1 h of recovery sleep (RS) on the recovery of this function. METHODS Twenty-seven healthy male participants performed a visual Go/No-Go task while event-related potentials (ERP) were recorded. Response inhibition was assessed at three time points: at baseline (0 h of TSD), after 30 h of TSD, and after 1 h of RS. RESULTS The results from the behavioral indicators revealed a significant increase in reaction times to the Go stimuli (p = 0.013), a decrease in accuracy (p < 0.001), and a substantial rise in the error rate for the No-Go stimuli (p = 0.001) after 30 h of TSD compared with baseline. After 30 h of TSD, there was no significant improvement in task performance after 1 h of RS. ERP analysis showed a significant prolongation of the latencies of N2 (p = 0.012) and P3 (p = 0.010), a significant increase in P3 amplitude (p = 0.048), and no significant change in N2 amplitude after TSD compared with that at baseline. After 1 h of RS, N2 amplitude significantly increased (p = 0.010) and P3 latency remained prolonged (p = 0.008). CONCLUSIONS After thirty hours of sleep deprivation, the brain maintains task performance primarily through compensatory mechanisms. 1 h of RS partially ameliorates the impaired response inhibition caused by thirty hours of sleep deprivation, restoring this function closer to baseline levels.
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Affiliation(s)
- Nan Zhang
- Department of Stress Disorder Treatment, The 8th Medical Center of Chinese PLA General Hospital, Beijing, China, 100091
| | - Xinran Wu
- School of Psychology, Beijing Sport University, Beijing, China, 100084
| | - Ningye Cui
- School of Psychology, Beijing Sport University, Beijing, China, 100084
| | - Yongcong Shao
- School of Psychology, Beijing Sport University, Beijing, China, 100084.
| | - Ying Zhang
- Department of Stress Disorder Treatment, The 8th Medical Center of Chinese PLA General Hospital, Beijing, China, 100091.
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Lolli L, Gregson W, Pulford A, Kanope T, Lopez E, Di Salvo V. Immediate effects of Ramadan on objective time asleep in male youth football players from the Middle East: an interrupted time-series study. SCI MED FOOTBALL 2025; 9:152-162. [PMID: 38753763 DOI: 10.1080/24733938.2024.2340112] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Accepted: 03/31/2024] [Indexed: 05/18/2024]
Abstract
OBJECTIVE To examine the abrupt effects of Ramadan onset on actigraphy-based time asleep in male youth Muslim football players. METHODS We adopted a quasi-experimental, interrupted time-series research design and tracked objective time asleep over a minimum of 12 consecutive nights in the two weeks prior to and immediately after Ramadan onset, respectively. Twenty-two, male academy student-athletes (chronological age range: 12.6 to 16.2 years) participated in the study (464 individual observations). Segmented generalized mixed-effects modelling estimated the effects of Ramadan onset on time asleep during the first period of night sleep only. RESULTS Ramadan onset led to an immediate mean reduction of 89 min (95% confidence interval [CI], 54 to 123 min) in time asleep during the first period of night sleep compared to pre-Ramadan sleep patterns. Model-adjusted estimated marginal means for time asleep were ~ 5.7 h (95%CI, 5.1 to 6.2 h) before and ~ 4.2 h (95%CI, 3.6 to 4.7 h) after Ramadan onset. Night sleep interruptions resulting in two or more fragmented periods accounted for 8% (95%CI, 2 to 21%) to 19% (95%, 11 to 29%) of sleep observations before and after Ramadan onset, respectively. CONCLUSIONS The onset of Ramadan determined an abrupt reduction in time asleep of ~ 1 h 30 min in the first period of a night cycle and contributed to additional problems of heterogeneous sleep fragmentation that can impact optimal school learning and youth athlete performance development processes.
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Affiliation(s)
- Lorenzo Lolli
- Football Performance & Science Department, Aspire Academy, Doha, Qatar
- Department of Sport and Exercise Sciences, Institute of Sport, Manchester Metropolitan University, Manchester, UK
| | - Warren Gregson
- Department of Sport and Exercise Sciences, Institute of Sport, Manchester Metropolitan University, Manchester, UK
| | - Adam Pulford
- Football Performance & Science Department, Aspire Academy, Doha, Qatar
| | - Tane Kanope
- Football Performance & Science Department, Aspire Academy, Doha, Qatar
| | - Emmanuel Lopez
- Football Performance & Science Department, Aspire Academy, Doha, Qatar
| | - Valter Di Salvo
- Football Performance & Science Department, Aspire Academy, Doha, Qatar
- Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy
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Morrison M, Weakley J, Roach GD, Sargent C, Miller DJ, Gardiner C, Halson SL. Quantifying the effect of afternoon moderate-intensity exercise on sleep quality and quantity in healthy adult males using polysomnography. J Sci Med Sport 2025:S1440-2440(25)00124-0. [PMID: 40393848 DOI: 10.1016/j.jsams.2025.04.008] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/24/2024] [Revised: 03/30/2025] [Accepted: 04/23/2025] [Indexed: 05/22/2025]
Abstract
OBJECTIVES To investigate the effect of afternoon moderate-intensity cycling exercise on objective and subjective sleep in healthy adult males. DESIGN Repeated-measures, counter-balanced, crossover study design. METHODS To assess the effect of moderate-intensity afternoon exercise on sleep quality and quantity, 12 healthy adult males who were identified as good sleepers (<5 on Pittsburgh Sleep Quality Index) completed either moderate-intensity cycling exercise for 40 min at 70 % HRmax at ~15:30 h or sedentary activities. Polysomnography was used to measure sleep during a 9-hour sleep opportunity (23:00 h to 08:00 h). Sleep was subjectively assessed using questionnaires 30 min after waking. RESULTS There were no statistically significant changes in objective or subjective sleep quality or quantity between conditions. The inter-quartile range for total sleep time (exercise: 51.5 min vs no exercise: 13.4 min) and sleep efficiency (exercise: 9.5 % vs no exercise: 2.5 %) suggests that there was more individual variability in subsequent sleep after afternoon exercise compared to no exercise. Exercise appeared to have a moderate effect on reducing total sleep time (mean ± SD; control 493.7 ± 12.6 min vs exercise: 471.5 ± 55.2 min; Cohen's d: -0.56), sleep efficiency (control 91.4 ± 2.3 % vs exercise: 87.3 ± 10.2 %; Cohen's d: -0.56), and delaying REM onset latency (control: 76.1 ± 45.1 min vs exercise: 102.8 ± 46.9 min; r: 0.33), although the results did not reach statistical significance (p > 0.05). CONCLUSIONS Healthy adult males can complete moderate-intensity exercise in the afternoon without compromising subsequent sleep. Individual responses in objective sleep outcomes may vary after exercise.
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Affiliation(s)
- Matthew Morrison
- School of Behavioural and Health Sciences, Australian Catholic University, Australia; Sports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre, Australian Catholic University, Australia; Centre for Human Factors and Sociotechnical Systems, University of the Sunshine Coast, Australia.
| | - Jonathon Weakley
- School of Behavioural and Health Sciences, Australian Catholic University, Australia; Sports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre, Australian Catholic University, Australia; Carnegie Applied Rugby Research (CARR) Centre, Institute of Sport, Physical Activity and Leisure, Leeds Beckett University, United Kingdom
| | - Gregory D Roach
- Appleton Institute for Behavioural Science, Central Queensland University, Australia
| | - Charli Sargent
- Appleton Institute for Behavioural Science, Central Queensland University, Australia
| | - Dean J Miller
- Appleton Institute for Behavioural Science, Central Queensland University, Australia
| | - Carissa Gardiner
- School of Behavioural and Health Sciences, Australian Catholic University, Australia; Sports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre, Australian Catholic University, Australia
| | - Shona L Halson
- School of Behavioural and Health Sciences, Australian Catholic University, Australia; Sports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre, Australian Catholic University, Australia
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Staiano W, Callahan C, Davis M, Tanner L, Coe C, Kunkle S, Kirk U. Assessment of an App-Based Sleep Program to Improve Sleep Outcomes in a Clinical Insomnia Population: Randomized Controlled Trial. JMIR Mhealth Uhealth 2025; 13:e68665. [PMID: 40267472 PMCID: PMC12059489 DOI: 10.2196/68665] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/11/2024] [Revised: 12/22/2024] [Accepted: 03/18/2025] [Indexed: 04/25/2025] Open
Abstract
BACKGROUND Insomnia is the most commonly reported sleep disturbance and significantly impacts mental health and quality of life. Traditional treatments for insomnia include pharmacological interventions or cognitive behavioral therapy for insomnia (CBT-I), but these options may not be accessible to everyone who needs treatment. OBJECTIVE This study aims to assess the effectiveness of the app-based Headspace Sleep Program in adults with clinical insomnia on sleep disturbance and mental health outcomes, compared with a waitlist control group. METHODS This randomized controlled trial included 132 adults with clinical insomnia who were assigned to either the Headspace Sleep Program (an 18-session self-guided, in-app program utilizing CBT-I techniques augmented by mindfulness) or a waitlist control group. Sleep disturbance outcomes were assessed by changes in insomnia symptoms (measured using the Insomnia Severity Index) and sleep efficiency (measured via sleep diary and actigraphy). Mental health outcomes included perceived stress (measured by the 10-item Perceived Stress Scale), depressive symptoms (measured by the 8-item Patient Health Questionnaire), sleep quality (measured by the Pittsburgh Sleep Quality Index), anxiety symptoms (measured by the 7-item Generalized Anxiety Disorder Scale), and mindfulness (measured by the Mindful Attention Awareness Scale). Changes from baseline to postintervention and follow-up were assessed for each outcome. RESULTS Participants had a mean (SD) age of 37.2 (10.6) years, with 69 out of 132 (52.3%) identifying as female. Those randomized to the Headspace Sleep Program group experienced significantly greater improvements in insomnia symptoms from baseline to postintervention and follow-up compared with participants in the waitlist control group (P<.001, η²p=0.107). Improvements from baseline to postintervention and follow-up were also observed in the Headspace Sleep Program group for sleep efficiency, as measured by both sleep diary (P=.01, η²p=.03) and actigraphy outcomes (P=.01, η²p=.03). Participants in the Headspace Sleep Program group showed greater improvements in insomnia remission rates (8/66, 12%, at postintervention and 9/66, 14%, at follow-up) and treatment response (11/66, 17%, at postintervention and 15/66, 23%, at follow-up) compared with the control group (remission rate 2/66, 3%, at postintervention and 0/66, 0%, at follow-up; treatment response 3/66, 5%, at postintervention and 1/66, 2%, at follow-up). The results suggest significant improvements in depressive symptoms (P=.01, η²p=.04), anxiety symptoms (P=.02, η²p=.02), and mindfulness (P=.01, η²p=.03) in the Headspace Sleep Program group. CONCLUSIONS The Headspace Sleep Program is an effective intervention for improving sleep disturbances in adults with clinical insomnia. TRIAL REGISTRATION ClinicalTrials.gov NCT05872672; https://clinicaltrials.gov/ct2/show/NCT05872672.
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Affiliation(s)
- Walter Staiano
- Department of Physical Education and Sport, Universitat de València, Valencia, Spain
- Department of Psychology, University of Southern Denmark, Odense, Denmark
| | | | | | | | | | | | - Ulrich Kirk
- Department of Psychology, University of Southern Denmark, Odense, Denmark
- Fralin Biomedical Research Institute, Roanoke, VA, United States
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Kaya E, Wegienka E, Akhtarzandi-Das A, Do H, Eban-Rothschild A, Rothschild G. Food intake enhances hippocampal sharp wave-ripples. eLife 2025; 14:RP105059. [PMID: 40227932 PMCID: PMC11996173 DOI: 10.7554/elife.105059] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 04/16/2025] Open
Abstract
Effective regulation of energy metabolism is critical for survival. Metabolic control involves various nuclei within the hypothalamus, which receive information about the body's energy state and coordinate appropriate responses to maintain homeostasis, such as thermogenesis, pancreatic insulin secretion, and food-seeking behaviors. It has recently been found that the hippocampus, a brain region traditionally associated with memory and spatial navigation, is also involved in metabolic regulation. Specifically, hippocampal sharp wave-ripples (SWRs), which are high-frequency neural oscillations supporting memory consolidation and foraging decisions, have been shown to reduce peripheral glucose levels. However, whether SWRs are enhanced by recent feeding-when the need for glucose metabolism increases, and if so, whether feeding-dependent modulation of SWRs is communicated to other brain regions involved in metabolic regulation-remains unknown. To address these gaps, we recorded SWRs from the dorsal CA1 region of the hippocampus of mice during sleep sessions before and after consumption of meals of varying caloric values. We found that SWRs occurring during sleep are significantly enhanced following food intake, with the magnitude of enhancement being dependent on the caloric content of the meal. This pattern occurred under both food-deprived and ad libitum feeding conditions. Moreover, we demonstrate that GABAergic neurons in the lateral hypothalamus, which are known to regulate food intake, exhibit a robust SWR-triggered increase in activity. These findings identify the satiety state as a factor modulating SWRs and suggest that hippocampal-lateral hypothalamic communication is a potential mechanism by which SWRs could modulate peripheral metabolism and food intake.
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Affiliation(s)
- Ekin Kaya
- Department of Psychology, University of MichiganAnn ArborUnited States
| | - Evan Wegienka
- Department of Psychology, University of MichiganAnn ArborUnited States
| | | | - Hanh Do
- Department of Psychology, University of MichiganAnn ArborUnited States
| | | | - Gideon Rothschild
- Department of Psychology, University of MichiganAnn ArborUnited States
- Kresge Hearing Research Institute and Department of Otolaryngology, Head and Neck Surgery, University of MichiganAnn ArborUnited States
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Torres-Carballo M, Galmes-Panades AM, Arias-Fernández M, Huguet-Torres A, Abbate M, Fresneda S, Sánchez-Rodríguez C, Yañez AM, Bennasar-Veny M. Isotemporal substitution of sedentary time with physical activity and sleeping time: associations with body composition among individuals with prediabetes. Front Sports Act Living 2025; 7:1579962. [PMID: 40260421 PMCID: PMC12009759 DOI: 10.3389/fspor.2025.1579962] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/19/2025] [Accepted: 03/24/2025] [Indexed: 04/23/2025] Open
Abstract
Aim To assess the association between physical activity (PA), sedentary time (ST), and sleep with body composition, and to explore the effects of reallocating ST to PA or sleep on body composition in individuals with prediabetes and overweight/obesity. Material methods and results Baseline data from the PREDIPHONE trial, including 159 participants (mean age 59.6 years) with prediabetes (Fasting Plasma Glucose 100-125 mg/dl) and overweight/obesity (Body Mass Index 27-40 kg/m²), were analyzed. Body composition was assessed via bioelectrical impedance, while PA, ST, and sleep were measured with accelerometry. Linear regression and isotemporal substitution models evaluated associations. Increased ST was positively associated with body fat mass (kg) (β = 0.016; CI 95%: 0.003-0.030), body fat mass (%) (β = 0.009; 0.001-0.018), and visceral adipose tissue (β = 0.005; 0.001-0.010). Moderate-to-vigorous PA (MVPA) was negatively associated with body fat mass (kg) [β = -0.031; 0.055- (-0.008)], body fat mass (%) [β = -0.017; -0.032-(-0.003)], and Visceral adipose tissue [β = -0.009; -0.02-(-0.002)]. Replacing ST with MVPA was linked to lower Visceral adipose tissue [β = -0.012; -0.024-(-0.001)] and body fat mass (kg) [β = -0.039; -0.074-(-0.006)], but not with lean mass. No significant associations were found when substituting ST with light PA or sleep. Discussion In individuals with prediabetes and overweight/obesity, replacing ST with MVPA could reduce body fat and VAT but not increases lean mass.
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Affiliation(s)
- M. Torres-Carballo
- Research Group on Global Health, University of Balearic Islands, Palma, Spain
- Primary Care of Mallorca, Public Health Service of the Balearic Islands, Palma, Spain
| | - A. M. Galmes-Panades
- Research Group on Nursing, Community & Global Health, Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain
- CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain
- Physical Activity and Sport Sciences Research Group (GICAFE), Institute for Educational Research and Innovation, University of the Balearic Islands, Palma, Spain
| | - M. Arias-Fernández
- Research Group on Global Health, University of Balearic Islands, Palma, Spain
- Research Group on Nursing, Community & Global Health, Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain
- Nursing and Physiotherapy Department, University of the Balearic Islands, Palma, Spain
| | - A. Huguet-Torres
- Research Group on Global Health, University of Balearic Islands, Palma, Spain
- Nursing and Physiotherapy Department, University of the Balearic Islands, Palma, Spain
| | - M. Abbate
- Research Group on Global Health, University of Balearic Islands, Palma, Spain
- Research Group on Nursing, Community & Global Health, Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain
| | - S. Fresneda
- Research Group on Global Health, University of Balearic Islands, Palma, Spain
- Research Group on Nursing, Community & Global Health, Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain
- Nursing and Physiotherapy Department, University of the Balearic Islands, Palma, Spain
| | - C. Sánchez-Rodríguez
- Research Group on Global Health, University of Balearic Islands, Palma, Spain
- Hospital Sant Joan de Deu, Palma, Spain
| | - A. M. Yañez
- Research Group on Global Health, University of Balearic Islands, Palma, Spain
- Research Group on Nursing, Community & Global Health, Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain
- Nursing and Physiotherapy Department, University of the Balearic Islands, Palma, Spain
- Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS), Palma, Spain
| | - M. Bennasar-Veny
- Research Group on Global Health, University of Balearic Islands, Palma, Spain
- Research Group on Nursing, Community & Global Health, Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain
- Nursing and Physiotherapy Department, University of the Balearic Islands, Palma, Spain
- Centre for Biomedical Research Network (CIBER) in Epidemiology and Public Health (CIBERESP), Madrid, Spain
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Akaarir M, Nicolau MC, Cañellas F, Rubiño JA, Barceló P, Gamundí A, Martin-Reina A, Rial RV. The Disputable Costs of Sleeping. BIOLOGY 2025; 14:352. [PMID: 40282216 PMCID: PMC12024767 DOI: 10.3390/biology14040352] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 07/26/2024] [Revised: 12/04/2024] [Accepted: 12/12/2024] [Indexed: 04/29/2025]
Abstract
It is currently affirmed that sleep detracts from time for foraging, reproductive, and anti-predatory activities. In contrast, we show that the sleep-related reductions in food intake and reproductive activities may, in fact, be benefits. Furthermore, the present report shows that the optimal prey are the immature, weak, sick, and senescent animals and rarely the sleeping fit adults. Indeed, the reduced sleeping time observed in prey animals occurs, not because of an evolutionary antipredation pressure but because of the time-expensive foraging-related activities and the digestion of the high-cellulose content in the herbivores' diet, an activity that leaves reduced amounts of daily time for sleeping. We conclude that the need for sleep ranks lower than those of foraging, reproduction, and antipredation activities.
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Affiliation(s)
- Mourad Akaarir
- Balearic Islands Health Research Institute (IUNICS), Universitat de les Illes Balears, 07122 Palma, Spain; (M.A.); (M.C.N.); (P.B.); (A.G.); (A.M.-R.)
| | - M. Cristina Nicolau
- Balearic Islands Health Research Institute (IUNICS), Universitat de les Illes Balears, 07122 Palma, Spain; (M.A.); (M.C.N.); (P.B.); (A.G.); (A.M.-R.)
| | - Francesca Cañellas
- Balearic Islands Health Research Institute (IUNICS), Hospital Universitario Son Espases, Universitat de les Illes Balears, 07122 Palma, Spain; (F.C.)
| | - Jose A. Rubiño
- Balearic Islands Health Research Institute (IUNICS), Universitat de les Illes Balears, 07122 Palma, Spain; (M.A.); (M.C.N.); (P.B.); (A.G.); (A.M.-R.)
| | - Pere Barceló
- Balearic Islands Health Research Institute (IUNICS), Universitat de les Illes Balears, 07122 Palma, Spain; (M.A.); (M.C.N.); (P.B.); (A.G.); (A.M.-R.)
| | - Antonio Gamundí
- Balearic Islands Health Research Institute (IUNICS), Universitat de les Illes Balears, 07122 Palma, Spain; (M.A.); (M.C.N.); (P.B.); (A.G.); (A.M.-R.)
| | - Aida Martin-Reina
- Balearic Islands Health Research Institute (IUNICS), Universitat de les Illes Balears, 07122 Palma, Spain; (M.A.); (M.C.N.); (P.B.); (A.G.); (A.M.-R.)
| | - Rubén V. Rial
- Balearic Islands Health Research Institute (IUNICS), Universitat de les Illes Balears, 07122 Palma, Spain; (M.A.); (M.C.N.); (P.B.); (A.G.); (A.M.-R.)
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Kumar R, Pandey A, Vibhuti A, Ali M, Chang CM, Pandey RP. Unlocking Mysteries: Exploring the Dynamic Interplay among Sleep, the Immune System, and Curcumin in Contemporary Research. Sleep Sci 2025. [DOI: 10.1055/s-0045-1802321] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 05/04/2025] Open
Abstract
AbstractThe scientific disciplines encompassing sleep, the immune system, and curcumin have garnered considerable interest due to their interconnectedness and potential implications for human health. Sleep is a crucial factor in maintaining optimal immune function, as it facilitates the release of cytokines, which are signaling molecules responsible for regulating immune responses. On the contrary, sleep deprivation has the potential of inhibiting immune function, thereby heightening the susceptibility to infection and disease. Curcumin, a naturally occurring polyphenol derived from the turmeric plant, has been observed to possess immunomodulatory characteristics through its ability to modulate the equilibrium between pro- and anti-inflammatory cytokines. It is worth noting that there is evidence suggesting that curcumin supplementation could enhance the quality of sleep. Scientific studies have indicated that curcumin supplementation has been associated with an increase in the duration of sleep and a decrease in wakefulness among individuals who are in good health. Additionally, curcumin supplementation has been found to enhance sleep quality and alleviate symptoms of depression in individuals diagnosed with major depressive disorder. The intricate interplay among sleep, the immune system, and curcumin is multifaceted, and scientific investigations indicate that curcumin may serve as a beneficial dietary adjunct to enhance immune function and optimize sleep quality. Nevertheless, additional investigation is required to fully comprehend the mechanisms through which curcumin alters the immune system and enhances sleep, as well as to ascertain the most effective dose and timing of curcumin supplementation.
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Affiliation(s)
- Rohit Kumar
- Department of Biotechnology, Sri Ramaswamy Memorial (SRM) University, Sonipat, Haryana, India
| | - Atul Pandey
- Department of Ecology and Evolutionary Biology, College of Literature, Science, and the Arts, University of Michigan, Ann Arbor, MI, United States
- Department of Entomology, Martin-Gatton College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY, United States
| | - Arpana Vibhuti
- Department of Biotechnology, Sri Ramaswamy Memorial (SRM) University, Sonipat, Haryana, India
| | - Manzoor Ali
- Genomics and Genome Biology Unit, Council of Scientific and Industrial Research, Institute of Genomics and Integrative Biology, Delhi, India
- Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India
| | - Chung-Ming Chang
- Chang Gung University, Guishan Dist, Taoyuan City, Taiwan
- Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Guishan Dist, Taoyuan City, Taiwan
- Laboratory Animal Center, Chang Gung University, Guishan Dist, Taoyuan City, Taiwan
| | - Ramendra Pati Pandey
- Department of Biotechnology, Sri Ramaswamy Memorial (SRM) University, Sonipat, Haryana, India
- School of Health Sciences and Technology, University of Petroleum and Energy Studies (UPES), Dehradun, Uttarakhand, India
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Feng C, Sweeney E. The Association of Sleep Trouble and Physical Inactivity with Breast Cancer Risk in Nova Scotia: Evidence from the Atlantic PATH Cohort. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2025; 22:471. [PMID: 40283700 PMCID: PMC12026704 DOI: 10.3390/ijerph22040471] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 12/28/2024] [Revised: 03/16/2025] [Accepted: 03/18/2025] [Indexed: 04/29/2025]
Abstract
Breast cancer is a major public health concern, and modifiable health behaviors such as sleep quality and physical activity may influence risk. This study examined the associations between self-reported sleep trouble, sleep duration, and physical activity with breast cancer incidence in a prospective longitudinal cohort of 10,305 females from Nova Scotia. Breast cancer cases were identified through record linkage to the Nova Scotia Cancer Registry. Multivariable logistic regression models were used to estimate adjusted odds ratios (AORs) and 95% confidence intervals (CIs), accounting for sociodemographic factors, reproductive history, comorbidities, and other health behaviors. Frequent sleep trouble ("all of the time") was significantly associated with increased odds of breast cancer (AOR = 2.41, 95% CI = 1.09-5.34, p = 0.03), while no significant associations were observed between sleep duration and breast cancer risk. High physical activity was significantly associated with a lower risk of breast cancer (AOR = 0.58, 95% CI = 0.39-0.86, p < 0.01). These findings suggest that frequent sleep disturbances may be associated with an increased risk of breast cancer, while high physical activity appears to be linked to a lower risk of breast cancer. Further research is needed to explore these relationships and their underlying mechanisms.
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Affiliation(s)
- Cindy Feng
- Department of Community Health and Epidemiology, Faculty of Medicine, Dalhousie University, Halifax, NS B3H 1V7, Canada;
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Phang CR, Hirata A. Explainable multiscale temporal convolutional neural network model for sleep stage detection based on electroencephalogram activities. J Neural Eng 2025; 22:026010. [PMID: 39983236 DOI: 10.1088/1741-2552/adb90c] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/18/2024] [Accepted: 02/21/2025] [Indexed: 02/23/2025]
Abstract
Objective.Humans spend a significant portion of their lives in sleep (an essential driver of body metabolism). Moreover, as sleep deprivation could cause various health complications, it is crucial to develop an automatic sleep stage detection model to facilitate the tedious manual labeling process. Notably, recently proposed sleep staging algorithms lack model explainability and still require performance improvement.Approach.We implemented multiscale neurophysiology-mimicking kernels to capture sleep-related electroencephalogram (EEG) activities at varying frequencies and temporal lengths; the implemented model was named 'multiscale temporal convolutional neural network (MTCNN).' Further, we evaluated its performance using an open-source dataset (Sleep-EDF Database Expanded comprising 153 d of polysomnogram data).Main results.By investigating the learned kernel weights, we observed that MTCNN detected the EEG activities specific to each sleep stage, such as the frequencies, K-complexes, and sawtooth waves. Furthermore, regarding the characterization of these neurophysiologically significant features, MTCNN demonstrated an overall accuracy (OAcc) of 91.12% and a Cohen kappa coefficient of 0.86 in the cross-subject paradigm. Notably, it demonstrated an OAcc of 88.24% and a Cohen kappa coefficient of 0.80 in the leave-few-days-out analysis. Our MTCNN model also outperformed the existing deep learning models in sleep stage classification even when it was trained with only 16% of the total EEG data, achieving an OAcc of 85.62% and a Cohen kappa coefficient of 0.75 on the remaining 84% of testing data.Significance.The proposed MTCNN enables model explainability and it can be trained with lesser amount of data, which is beneficial to its application in the real-world because large amounts of training data are not often and readily available.
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Affiliation(s)
- Chun-Ren Phang
- Department of Electrical and Mechanical Engineering, and the Center of Biomedical Physics and Information Technology, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555 Aichi, Japan
- DNAKE BCI Lab, Brain-Computer Interaction Business Unit, DNAKE (Xiamen) Intelligent Technology CO., LTD, Xiamen, Fujian, People's Republic of China
| | - Akimasa Hirata
- Department of Electrical and Mechanical Engineering, and the Center of Biomedical Physics and Information Technology, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555 Aichi, Japan
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12
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Mortlock E, English H, Börger L, Matas D, Koren L, Capellini I, Jennings D. Drivers of individual differences in the sleep behaviour of fallow deer neonates. J Anim Ecol 2025; 94:449-461. [PMID: 39891496 PMCID: PMC11880652 DOI: 10.1111/1365-2656.14247] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/18/2024] [Accepted: 01/13/2025] [Indexed: 02/03/2025]
Abstract
Inter-individual differences are necessary for selection to act, while plasticity (intra-individual variation) may buffer against selection. Sleep is a critical self-maintenance behaviour but, unlike most behaviours, the causes and consequences of its inter- and intra-individual variation in wild animals is poorly understood, particularly in neonates where sleep plays a key role in development. We have shown previously that free-ranging neonate fallow deer (Dama dama) differ in sleep during the first few weeks of life. Here, we test whether individual variability in sleep is organised systematically across the population, and whether these individual differences are associated with chronic stress measured using hair cortisol, or the timing of birth. Four dimensions of sleep behaviour (total sleep time, sleep fragmentation, sleep quality, and sleep distribution over 24-h) were quantified using state-of-the-art triaxial accelerometers. We then used a multivariate mixed-effects model in a Bayesian framework to evaluate covariation between multiple dimensions of sleep behaviour, and quantify the relative importance of chronic stress and the timing of birth, while accounting for the confounding effects of environmental conditions and age. We found that the timing of birth and chronic stress were not associated with changes in sleep between individuals. While both total sleep time and the number of bouts per day declined with age, their rate of development covaried, but no other sleep dimensions covaried. Our results represent an in-depth analysis of natural variation in sleep, and show that individual differences in four aspects of sleep architecture in free-living fallow deer fawns are strong but independent of one another and unrelated to chronic stress or the timing of birth. We suggest that covariation between sleep dimensions might emerge later in life and effects of cortisol and birth timing might be very short and transient.
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Affiliation(s)
- Euan Mortlock
- School of Biological SciencesQueen's University BelfastBelfastUK
- School of Physiology, Pharmacology, and NeuroscienceUniversity of BristolBristolUK
| | - Holly English
- School of Biology and Environmental ScienceUniversity College DublinDublinIreland
| | - Luca Börger
- Department of BiosciencesSwansea UniversitySwanseaUK
| | - Devorah Matas
- The Mina and Everard Goodman Faculty of Life SciencesBar‐Ilan UniversityRamat‐GanIsrael
| | - Lee Koren
- The Mina and Everard Goodman Faculty of Life SciencesBar‐Ilan UniversityRamat‐GanIsrael
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Stamatakis E, Koemel NA, Biswas RK, Ahmadi MN, Allman-Farinelli M, Trost SG, Inan-Eroglu E, Del Pozo Cruz B, Bin YS, Postnova S, Duncan MJ, Dumuid D, Brown H, Maher C, Fontana L, Simpson S, Cistulli PA. Minimum and optimal combined variations in sleep, physical activity, and nutrition in relation to all-cause mortality risk. BMC Med 2025; 23:111. [PMID: 40001093 PMCID: PMC11863424 DOI: 10.1186/s12916-024-03833-x] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/12/2024] [Accepted: 12/18/2024] [Indexed: 02/27/2025] Open
Abstract
BACKGROUND Sleep, physical activity, and nutrition (SPAN) are critical behaviours for health, although they have traditionally been studied separately. We examined the combined associations of SPAN and the minimum between-individual variations associated with meaningfully lower all-cause mortality risk. METHODS This prospective cohort analysis included 59,078 participants from the UK Biobank (median age: 64.0 years; 45.4% male) who wore trackers for 7 days and self-reported dietary data. Wearable-measured sleep (hours/day) and moderate to vigorous physical activity (MVPA; mins/day) were calculated using a machine learning based schema. A 10-item diet quality score (DQS) assessed the intake of vegetables, fruits, fish, dairy, whole grains, vegetable oils, refined grains, processed and unprocessed meats, and sugary beverages (0-100 for all components with higher values indicating higher quality). Cox proportional hazards models were used to estimate hazard ratios (HR) for all-cause mortality risk across 27 separate joint tertile combinations of SPAN behaviours with the lowest tertile for all three as the referent group. For more granular clinical interpretations, we examined combined incremental dose-response changes of the SPAN behaviours using the 5th percentile of each behaviour as the referent point. RESULTS Over the 8.1-year median follow-up time, 2,458 mortality events occurred. Compared to the referent group of combined SPAN exposure (lowest tertiles for all three), the optimal SPAN combination involving moderate sleep duration (7.2-8.0 h/day), high MVPA (42-103 min/day), and a DQS between 57.5 and 72.5 was associated with an HR of 0.36 (95% CI: 0.26-0.50). Relative to the 5th percentile of sleep (5.5 h/day), physical activity (7.3 min/day), and nutrition (36.9 DQS), a theoretical minimum combined increase of 15 min/day of sleep, 1.6 min/day MVPA, and 5 DQS points (corresponding to e.g., extra 1/2 serving of vegetables per day or 1 less serving of processed meat per week) was associated with 10% lower all-cause mortality risk (0.90; 0.88-0.93). Combined increases of 75 min/day of sleep, 12.5 min/day MVPA, and 25 DQS points were associated with 50% lower all-cause mortality risk (0.50; 0.44-0.58). CONCLUSIONS This study highlights the potential health value of subtle combined SPAN modification in relation to mortality risk and expands opportunities for more holistic recommendations.
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Affiliation(s)
- Emmanuel Stamatakis
- Mackenzie Wearables Research Hub, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
- School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
| | - Nicholas A Koemel
- Mackenzie Wearables Research Hub, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia
- School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia
| | - Raaj K Biswas
- Mackenzie Wearables Research Hub, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia
- School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia
| | - Matthew N Ahmadi
- Mackenzie Wearables Research Hub, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia
- School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia
| | - Margaret Allman-Farinelli
- Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia
- Nutrition and Dietetics, School of Nursing, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia
| | - Stewart G Trost
- School of Human Movement and Nutrition Sciences, The University of Queensland, and Children's Health Queensland, Brisbane, QLD, Australia
| | - Elif Inan-Eroglu
- Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
| | - Borja Del Pozo Cruz
- Faculty of Sports Sciences, Universidad Europea de Madrid, Madrid, Spain
- Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Madrid, Spain
- Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark
| | - Yu Sun Bin
- Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia
- Northern Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia
| | - Svetlana Postnova
- Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia
- School of Physics, Faculty of Science, The University of Sydney, Sydney, NSW, Australia
| | - Mitch J Duncan
- School of Medicine and Public Health, College of Health, Medicine, and Wellbeing, The University of Newcastle, University Drive, Callaghan, NSW, Australia
- Centre for Active Living and Learning, University of Newcastle, Callaghan, NSW, Australia
| | - Dorothea Dumuid
- Alliance for Research in Exercise, Nutrition and Activity, Allied Health and Human Performance, University of South Australia, Adelaide, South Australia, Australia
| | - Helen Brown
- School of Exercise and Nutrition Sciences, Faculty of Health, Deakin University, Geelong, VIC, Australia
| | - Carol Maher
- Alliance for Research in Exercise, Nutrition and Activity, Allied Health and Human Performance, University of South Australia, Adelaide, South Australia, Australia
| | - Luigi Fontana
- Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia
- Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
| | - Stephen Simpson
- Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia
- School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia
| | - Peter A Cistulli
- Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia
- Northern Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia
- Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, Sydney, NSW, Australia
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Kaya E, Wegienka E, Akhtarzandi-Das A, Do H, Eban-Rothschild A, Rothschild G. Food intake enhances hippocampal sharp wave-ripples. BIORXIV : THE PREPRINT SERVER FOR BIOLOGY 2025:2024.10.08.617304. [PMID: 39416018 PMCID: PMC11482785 DOI: 10.1101/2024.10.08.617304] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Download PDF] [Subscribe] [Scholar Register] [Indexed: 10/19/2024]
Abstract
Effective regulation of energy metabolism is critical for survival. Metabolic control involves various nuclei within the hypothalamus, which receive information about the body's energy state and coordinate appropriate responses to maintain homeostasis, such as thermogenesis, pancreatic insulin secretion, and food-seeking behaviors. It has recently been found that the hippocampus, a brain region traditionally associated with memory and spatial navigation, is also involved in metabolic regulation. Specifically, hippocampal sharp wave ripples (SWRs), which are high-frequency neural oscillations supporting memory consolidation and foraging decisions, have been shown to reduce peripheral glucose levels. However, whether SWRs are enhanced by recent feeding-when the need for glucose metabolism increases, and if so, whether feeding-dependent modulation of SWRs is communicated to other brain regions involved in metabolic regulation, remains unknown. To address these gaps, we recorded SWRs from the dorsal CA1 region of the hippocampus of mice during sleep sessions before and after consumption of meals of varying caloric values. We found that SWRs occurring during sleep are significantly enhanced following food intake, with the magnitude of enhancement being dependent on the caloric content of the meal. This pattern occurred under both food-deprived and ad libitum feeding conditions. Moreover, we demonstrate that GABAergic neurons in the lateral hypothalamus, which are known to regulate food intake, exhibit a robust SWR-triggered increase in activity. These findings identify the satiety state as a factor modulating SWRs and suggest that hippocampal-lateral hypothalamic communication is a potential mechanism by which SWRs could modulate peripheral metabolism and food intake.
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Affiliation(s)
- Ekin Kaya
- Department of Psychology, University of Michigan, Ann Arbor, MI, 48109, USA
| | - Evan Wegienka
- Department of Psychology, University of Michigan, Ann Arbor, MI, 48109, USA
| | | | - Hanh Do
- Department of Psychology, University of Michigan, Ann Arbor, MI, 48109, USA
| | | | - Gideon Rothschild
- Department of Psychology, University of Michigan, Ann Arbor, MI, 48109, USA
- Kresge Hearing Research Institute and Department of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA
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Xie H, Chen C, Li T, Xu L, Liang J, Wen J, Chen G, Cai L. Weight-adjusted-waist index is associated with increased risk of sleep disturbances in the U.S. adult population: an analysis of NHANES 2007-2012. Eat Weight Disord 2025; 30:15. [PMID: 39928279 PMCID: PMC11811478 DOI: 10.1007/s40519-025-01722-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/22/2024] [Accepted: 01/20/2025] [Indexed: 02/11/2025] Open
Abstract
OBJECTIVE The weight-adjusted-waist index (WWI) is a novel measure of central adiposity, potentially linked to various sleep disturbances. This study explores the relationship between WWI and sleep outcomes, such as trouble sleeping, sleep disorder, and sleep duration. METHODS Data from the National Health and Nutrition Examination Survey 2007-2012 were analyzed, including 13,494 participants. The analysis focused on individuals aged 20 years and older who provided information on WWI and sleep. Sleep status was determined based on responses to the following questions: (1) "How many hours do you sleep?"; (2) if they reported trouble sleeping; and (3) if they had physician-diagnosed sleep disorders. Regression models assessed the association between WWI and sleep outcomes across the entire population and within subgroups. Restricted cubic spline (RCS) analysis was conducted to examine potential non-linear relationships between WWI and sleep outcomes. RESULTS A higher WWI was significantly correlated with an increased likelihood of trouble sleeping (OR = 1.26, 95% CI: 1.16, 1.36; p < 0.001) and sleep disorder (OR = 1.71, 95% CI: 1.50, 1.95; p < 0.001) in the overall population. RCS analysis indicated a linear relationship between WWI and these sleep outcomes. Subgroup analysis identified that the connection between WWI and trouble sleeping was most pronounced among Non-Hispanic Blacks and individuals with lower educational levels. For sleep disorder, the association was stronger in males and Non-Hispanic Blacks. A slight negative association between WWI and sleep duration was found, especially among non-drinkers (β = - 0.13, 95% CI: - 0.24, - 0.02; p = 0.028). CONCLUSION The findings highlight a significant and linear relationship between elevated WWI and an increased likelihood of experiencing trouble sleeping and sleep disorder, with variations observed across different demographic and lifestyle subgroups. These results imply that central adiposity, as measured by WWI, plays an important role in sleep health. LEVEL OF EVIDENCE Level III: Evidence obtained from well-designed cohort or case-control analytic studies.
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Affiliation(s)
- Haiping Xie
- Department of Rheumatology and Immunology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China
| | - Chuhui Chen
- Department of Endocrinology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, NO.134, East Street, Gulou District, Fuzhou, 350001, China
| | - Ting Li
- Department of Endocrinology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, NO.134, East Street, Gulou District, Fuzhou, 350001, China
| | - Lizhen Xu
- Department of Endocrinology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, NO.134, East Street, Gulou District, Fuzhou, 350001, China
| | - Jixing Liang
- Department of Endocrinology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, NO.134, East Street, Gulou District, Fuzhou, 350001, China
| | - Junping Wen
- Department of Endocrinology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, NO.134, East Street, Gulou District, Fuzhou, 350001, China.
| | - Gang Chen
- Department of Endocrinology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, NO.134, East Street, Gulou District, Fuzhou, 350001, China.
| | - Liangchun Cai
- Department of Endocrinology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, NO.134, East Street, Gulou District, Fuzhou, 350001, China.
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Sharma V, Kumar A, Choudhary N, Ray S, Khurana D, Avti PK, Chakravarty K. Association of retinol binding protein and the risk of idiopathic intracranial hypertension: a systematic review and meta-analysis. Acta Neurol Belg 2025:10.1007/s13760-025-02739-6. [PMID: 39920443 DOI: 10.1007/s13760-025-02739-6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/05/2024] [Accepted: 01/30/2025] [Indexed: 02/09/2025]
Abstract
BACKGROUND Idiopathic Intracranial Hypertension (IIH) is a disease of unknown etiology. Understanding the role of Retinol Binding Protein (RBP) in IIH pathogenesis could provide valuable perceptions into disease mechanisms and potentially identify new therapeutic targets. METHODS The study conducted a comprehensive search of electronic databases following PRISMA guidelines. The inclusion criteria involved human studies published in English that reported RBP levels in IIH patients. The New Castle Ottawa scale was used for the quality assessment of the included studies. Analysis was done using the Random Effects Model with 95% Confidence Interval. RESULTS A total of 4 studies met the inclusion criteria for meta-analysis. The quality score for the included studies ranged from 5 to 6. The pooled analysis indicated significant association of RBP with risk of IIH, with higher serum RBP levels (SMD = 1.56, 95% CI: 0.13 to 2.98, I2 = 93.9) and lower CSF RBP levels (SMD = -0.67, 95% CI: -1.37 to 0.04, I2 = 65.4) as compared to controls. Significant heterogeneity was found in the studies, suggesting variability in study design and methods. Further subgroup analysis by investigation method also showed significant results (SMD = 1.56, 95% CI: 0.13 to 2.98, I2 = 93.9). CONCLUSION The findings of this study propose that an elevated level of RBP may contribute to the risk of IIH, potentially through its involvement in retinol transport and metabolism. The study has been registered in PROSPERO (CRD42023436827).
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Affiliation(s)
- Vaishali Sharma
- Department of Neurology , Post Graduate Institute of Medical Education and Research, PGIMER, Chandigarh, India
| | - Amit Kumar
- Department of Neurology , Post Graduate Institute of Medical Education and Research, PGIMER, Chandigarh, India
| | - Neetu Choudhary
- Department of Neurology , Post Graduate Institute of Medical Education and Research, PGIMER, Chandigarh, India
| | - Sucharita Ray
- Department of Neurology , Post Graduate Institute of Medical Education and Research, PGIMER, Chandigarh, India
| | - Dheeraj Khurana
- Department of Neurology , Post Graduate Institute of Medical Education and Research, PGIMER, Chandigarh, India
| | - Pramod Kumar Avti
- Department of Biophysics, Post Graduate Institute of Medical Education and Research, PGIMER, Chandigarh, India
| | - Kamalesh Chakravarty
- Department of Neurology , Post Graduate Institute of Medical Education and Research, PGIMER, Chandigarh, India.
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Fakroune S, Van den Broucke S. Determinants of unhealthy sleeping habits among Belgian university students: an application of the Theory of Planned Behavior. JOURNAL OF AMERICAN COLLEGE HEALTH : J OF ACH 2025; 73:691-699. [PMID: 37437214 DOI: 10.1080/07448481.2023.2232883] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 10/22/2020] [Revised: 01/02/2023] [Accepted: 06/27/2023] [Indexed: 07/14/2023]
Abstract
Objectives: This study investigated if unhealthy sleeping habits of university students can be explained by the Theory of Planned Behavior. Method: An online questionnaire was administered to 1006 undergraduate students at a Belgian university to measure their frequency of irregular sleeping times, daytime napping, and pre-bedtime alcohol or internet use, as well as the attitudes, perceived norms, perceived control and intentions for these behaviors. Results: Principal Component Analysis and internal consistency analysis confirmed the validity and reliability of the scales measuring the TPB dimensions. Expected outcomes, perceived norms and perceived control significantly explained intentions to avoid irregular sleeping times, daytime naps, pre-bedtime activity and pre-bedtime alcohol use. Intentions and perceived behavioral control explained self-reported irregular sleeping times, daytime napping, pre-bedtime activity, and pre-bedtime alcohol use. Significant differences in predictions were found for gender, study program, type of residence and age. Conclusions: The TPB provides a useful theoretical framework to explain students' sleeping behaviors.
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Affiliation(s)
- Sarah Fakroune
- Psychological Sciences Research Institute, Université catholique de Louvain, Ottignies-Louvain-la-Neuve, Belgium
| | - Stephan Van den Broucke
- Psychological Sciences Research Institute, Université catholique de Louvain, Ottignies-Louvain-la-Neuve, Belgium
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Cao Q, Zhang P, Liu F, Jin M, Wang Y, Zeng H, Weng X, Xu F. The effect of deep magnetic stimulation on the cardiac-brain axis post-sleep deprivation: a pilot study. Front Neurosci 2025; 18:1464299. [PMID: 39867450 PMCID: PMC11757894 DOI: 10.3389/fnins.2024.1464299] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/13/2024] [Accepted: 12/30/2024] [Indexed: 01/28/2025] Open
Abstract
Introduction Sleep deprivation (SD) significantly disrupts the homeostasis of the cardiac-brain axis, yet the neuromodulation effects of deep magnetic stimulation (DMS), a non-invasive and safe method, remain poorly understood. Methods Sixty healthy adult males were recruited for a 36-h SD study, they were assigned to the DMS group or the control group according to their individual willing. All individuals underwent heart sound measurements and functional magnetic resonance imaging scans at the experiment's onset and terminal points. During the recovery sleep phase, DMS was applied twice for 30 min before sleep onset and upon awakening to the individuals in the DMS group. Two-factor analysis was used to disclose the changes in two status and intervention effect in groups, along with Spearman rank correlation analysis to assess the correlation between brain activity and heart activity, the linear regression analysis was performed to explore the effect of DMS on brain regions to regulated the heart activity. Additionally, bootstrapping analysis was employed to verify the mediation effect. Results The results indicated that the DMS group cardiac cycle duration was 0.81 ± 0.04 s, CON group was 0.80 ± 0.03 s, DMS presented a prolong effect (F = 0.32, p = 0.02), and all heart frequency and intensity indexes value were lower than CON group (p < 0.01). Two-factor analysis demonstrated the significant differences in the left insula and orbitofrontal inferior gyrus, which DC_Weight (0.25) value were lower 0.50 (p < 0.01), 0.42 (p < 0.01) after DMS. Furthermore, the correlation analysis confirmed that the negative association between the left orbital inferior frontal and left insula with the heart sound index (p < 0.05), such as Δ left orbital inferior frontal were negatively correlated with Δ Systolic_intensity (rho = -0.33, p < 0.05), Δ Diastolic_intensity (rho = -0.41, p < 0.05), Δ S1_intensity (rho = -0.36, p < 0.05), and Δ S2_intensity (rho = -0.43, p < 0.05). Δ Left insula was negatively correlated with Δ Diastolic_intensity (rho = -0.36, p < 0.05), Δ S1_intensity (rho = -0.33, p < 0.05), and Δ S2_intensity (rho = -0.36, p < 0.05). Mediated effect analysis showed that DMS affected S2_intensity by intervening in brain regions. Conclusion These findings suggest a causal effect on the cardiac-brain axis following 36 h of SD. The non-invasive intervention of DMS effectively regulates both brain and heart functions after SD, promoting homeostatic balance. The DMS can affect the cardiac-brain axis, offering a means to restore balance following extended periods of SD.
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Affiliation(s)
- Qiongfang Cao
- Department of Evidence-Based Medicine and Social Medicine, School of Public Health, Chengdu Medical College, Chengdu, Sichuan, China
| | - Peng Zhang
- Department of Evidence-Based Medicine and Social Medicine, School of Public Health, Chengdu Medical College, Chengdu, Sichuan, China
| | - Fangfang Liu
- Art College of Southwest Minzu University, Chengdu, Sichuan, China
| | - Mengyan Jin
- Department of Internal Medicine, West China Hospital of Sichuan University, Chengdu, China
| | - Yuhan Wang
- Department of Evidence-Based Medicine and Social Medicine, School of Public Health, Chengdu Medical College, Chengdu, Sichuan, China
| | - Hanrui Zeng
- Department of Radiology, Sichuan Taikang Hospital, Chengdu, Sichuan, China
| | - Xiechuan Weng
- Department of Neuroscience, Beijing Institute of Basic Medical Sciences, Beijing, China
| | - Fan Xu
- Department of Evidence-Based Medicine and Social Medicine, School of Public Health, Chengdu Medical College, Chengdu, Sichuan, China
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Zhang C, Deng D, Wu Y, Song L, Geng J, Feng H, Jiang S, Zhang K, Cheng Y, Yin S. New insights into the neurophysiological effects of heat stress on the Chinese mitten crab (Eriocheir sinensis). J Therm Biol 2025; 127:104055. [PMID: 39818005 DOI: 10.1016/j.jtherbio.2025.104055] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/21/2024] [Revised: 01/09/2025] [Accepted: 01/09/2025] [Indexed: 01/18/2025]
Abstract
Climate warming and frequent incidents of extreme high temperatures are serious global concerns. Heat stress induced by high temperature has many adverse effects on animal physiology, especially in aquatic poikilotherms. Chinese mitten crab (Eriocheir sinensis) is sensitive to high temperatures, this study evaluated the harmful effects of heat stress on the neurotoxicity, intestinal health, microbial diversity, and metabolite profiles. The results showed that heat stress caused histopathological damages and altered the ultrastructure of lesions in the cranial ganglia. Heat stress significantly upregulated the mRNA expression of apoptosis-related genes, and significantly altered the expression of neurotransmitter receptors. In addition, heat stress induced significant intestinal damages that mainly manifested as a significant increase in the activity of diamine oxidase in the serum and contents of histamine in the intestine. The diversity and abundance of intestinal microbiota altered abnormally in E. sinensis exposed to heat stress, and the bacteria that exhibited significant variations in abundance were closely related to the production of neurotransmitters and neuromodulators. Heat stress caused significant changes in the intestinal metabolite profiles, which mainly involved the amino acid and lipid metabolism pathways. Analysis of the correlation showed that the abnormal changes in metabolites were closely related to differences in the abundance of intestinal microbiota. Therefore, this study showed that heat stress could cause neurophysiological toxic effects, which may be related to intestinal ecological imbalance.
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Affiliation(s)
- Cong Zhang
- College of Marine Science and Engineering, Nanjing Normal University, Jiangsu Province Engineering Research Center for Aquatic Animals Breeding and Green Efficient Aquacultural Technology, Nanjing, 210023, PR China.
| | - Dunqian Deng
- College of Marine Science and Engineering, Nanjing Normal University, Jiangsu Province Engineering Research Center for Aquatic Animals Breeding and Green Efficient Aquacultural Technology, Nanjing, 210023, PR China
| | - Yi Wu
- College of Marine Science and Engineering, Nanjing Normal University, Jiangsu Province Engineering Research Center for Aquatic Animals Breeding and Green Efficient Aquacultural Technology, Nanjing, 210023, PR China
| | - Lexue Song
- College of Marine Science and Engineering, Nanjing Normal University, Jiangsu Province Engineering Research Center for Aquatic Animals Breeding and Green Efficient Aquacultural Technology, Nanjing, 210023, PR China
| | - Jiayin Geng
- College of Marine Science and Engineering, Nanjing Normal University, Jiangsu Province Engineering Research Center for Aquatic Animals Breeding and Green Efficient Aquacultural Technology, Nanjing, 210023, PR China
| | - Huixia Feng
- College of Marine Science and Engineering, Nanjing Normal University, Jiangsu Province Engineering Research Center for Aquatic Animals Breeding and Green Efficient Aquacultural Technology, Nanjing, 210023, PR China
| | - Su Jiang
- College of Marine Science and Engineering, Nanjing Normal University, Jiangsu Province Engineering Research Center for Aquatic Animals Breeding and Green Efficient Aquacultural Technology, Nanjing, 210023, PR China
| | - Kai Zhang
- College of Marine Science and Engineering, Nanjing Normal University, Jiangsu Province Engineering Research Center for Aquatic Animals Breeding and Green Efficient Aquacultural Technology, Nanjing, 210023, PR China
| | - Yongxu Cheng
- Key Laboratory of Integrated Rice-Fish Farming Ecosystem, Ministry of Agriculture and Rural Affairs, Shanghai Ocean University, Shanghai, 201306, PR China
| | - Shaowu Yin
- College of Marine Science and Engineering, Nanjing Normal University, Jiangsu Province Engineering Research Center for Aquatic Animals Breeding and Green Efficient Aquacultural Technology, Nanjing, 210023, PR China.
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Li W, Cai J, Liao G, Kwan MP, Tse LA. Individual-level noise exposure and its association with sleep quality and duration: A cross-sectional study using real-time data. THE SCIENCE OF THE TOTAL ENVIRONMENT 2024; 955:177047. [PMID: 39447902 DOI: 10.1016/j.scitotenv.2024.177047] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 09/16/2024] [Revised: 10/13/2024] [Accepted: 10/16/2024] [Indexed: 10/26/2024]
Abstract
As urban populations grow, the problem of noise pollution becomes more significant. The limited number of epidemiological studies linking individual-level dynamic noise exposure to sleep highlights a gap in our understanding of how individual-level noise exposure impact sleep quality and duration. A cross-sectional survey was conducted in Hong Kong, and portable noise sensors were used to record participants' real-time noise exposure. The Pittsburgh Sleep Quality Index was used to assess their sleep quality. Logistic regression was used to examine the relationship of individual-level noise exposure with sleep quality and sleep duration. Among a total of 763 subjects included in the analysis, and a-weighted decibels [dB(A)] 24-h average exposure (L24) was 63.21 (58.85-67.85) dB(A) for workday and 63.52 (59.03-67.86) dB(A) for non-workday. A significant decrease in individual noise level was observed closer to bedtime (P < 0.05). Compared with the lowest noise exposure, exposure to the highest noise level was positively associated with the presence of poor sleep quality for L24, Ld and Ln, with an odds ratio (OR) and 95 % confidential interval (CI) of 1.53 (1.04-2.24), 1.65 (1.12-2.43), and 1.51 (1.03-2.21), respectively. Exposure to elevated noise level was associated with increased risk of shorter nocturnal sleep duration (< 7 h), the OR and 95 % CI was 1.87 (1.29-2.73) for L24, 1.58 (1.09-2.30) for Ld, 1.50 (1.03-2.18) for Le, and 1.60 (1.10-2.32) for Ln in the highest noise exposure group. Similar findings were observed both on workdays and non-workdays, respectively. Furthermore, the results showed that each 10 dB(A) increment in L24 and Ln was associated with a probable 29 % and 27 % increase in poor sleep quality and a 24 % and 24 % reduction in sleep duration. This study demonstrates that environmental noise exposure was associated with poor sleep quality and shorter sleep duration, posing a significant public health issue in Hong Kong.
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Affiliation(s)
- Wenzhen Li
- Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, SAR, China; Shenzhen Research Institute of the Chinese University of Hong Kong, Shenzhen, China
| | - Jiannan Cai
- Institute of Space and Earth Information Science, The Chinese University of Hong Kong, Hong Kong, SAR, China
| | - Gengze Liao
- Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, SAR, China
| | - Mei-Po Kwan
- Institute of Space and Earth Information Science, The Chinese University of Hong Kong, Hong Kong, SAR, China; Department of Geography and Resource Management, The Chinese University of Hong Kong, Hong Kong, SAR, China.
| | - Lap Ah Tse
- Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, SAR, China; Shenzhen Research Institute of the Chinese University of Hong Kong, Shenzhen, China.
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21
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Luff CE, de Lecea L. Can Neuromodulation Improve Sleep and Psychiatric Symptoms? Curr Psychiatry Rep 2024; 26:650-658. [PMID: 39352645 DOI: 10.1007/s11920-024-01540-1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 11/22/2024]
Abstract
PURPOSE OF REVIEW In this review, we evaluate recent studies that employ neuromodulation, in the form of non-invasive brain stimulation, to improve sleep in both healthy participants, and patients with psychiatric disorders. We review studies using transcranial electrical stimulation, transcranial magnetic stimulation, and closed-loop auditory stimulation, and consider both subjective and objective measures of sleep improvement. RECENT FINDINGS Neuromodulation can alter neuronal activity underlying sleep. However, few studies utilizing neuromodulation report improvements in objective measures of sleep. Enhancements in subjective measures of sleep quality are replicable, however, many studies conducted in this field suffer from methodological limitations, and the placebo effect is robust. Currently, evidence that neuromodulation can effectively enhance sleep is lacking. For the field to advance, methodological issues must be resolved, and the full range of objective measures of sleep architecture, alongside subjective measures of sleep quality, must be reported. Additionally, validation of effective modulation of neuronal activity should be done with neuroimaging.
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Affiliation(s)
- Charlotte E Luff
- Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA
- Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, CA, USA
| | - Luis de Lecea
- Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.
- Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, CA, USA.
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22
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Li Y, Garg PK, Wu J. Associations between daytime napping, sleep duration, and depression and 15 cardiovascular diseases: a Mendelian randomization study. Cardiovasc Diagn Ther 2024; 14:771-787. [PMID: 39513145 PMCID: PMC11538837 DOI: 10.21037/cdt-24-313] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/02/2024] [Accepted: 09/13/2024] [Indexed: 11/15/2024]
Abstract
Background Numerous studies have documented the effects of daytime napping, sleep duration, and depression on cardiovascular diseases (CVDs). However, the evidence has been gleaned from observational studies that might be riddled with confounding variables and the possibility of reverse causation bias. Therefore, the present study employed a Mendelian randomization (MR) methodology to meticulously explore the relationships between daytime napping, sleep duration, and depression, and the risk profiles of CVDs. Methods Genome-wide significant genetic variants associated with daytime napping, sleep duration, and depression were used as the instrumental variables (IVs). Data on the genetic correlations between these IVs and 15 CVDs were derived from the United Kingdom (UK) Biobank, Finnish Genome Studies, and other large-scale collaborations. We conducted both univariate and multivariate MR analyses to assess the overall effects and mediated relationships after adjusting for potential confounders, including body mass index (BMI), smoking status, and type 2 diabetes. The effect sizes were estimated using inverse variance-weighted (IVW) regression. Results The MR analysis revealed that an increased risk of heart failure (HF) [odds ratio (OR): 1.366; 95% confidence interval (CI): 1.013-1.842; P=0.04], coronary atherosclerosis (OR: 1.918; 95% CI: 1.257-2.927; P=0.003), myocardial infarction (MI) (OR: 1.505; 95% CI: 1.025-2.211; P=0.04), and coronary artery disease (CAD) (OR: 1.519; 95% CI: 1.130-2.043; P=0.006) was significantly associated with genetically predicted daytime napping. Prolonged sleep duration was found to be related to a reduced risk of HF (OR: 0.995; 95% CI: 0.993-0.998; P=2.69E-04), peripheral vascular disease (PVD) (OR: 0.984; 95% CI: 0.971-0.997; P=0.02), and CAD (OR: 0.997; 95% CI: 0.994-0.999; P=0.006). Additionally, a statistically significant positive relationship was observed between depressive disorders and the occurrence of atrial fibrillation (AF) (OR: 1.298, 95% CI: 1.065-1.583, P=0.01), indicating a heightened susceptibility. The multivariable MR analyses substantiated the reliability of the observed associations between daytime napping and the incidence of HF and CAD, following adjustments for genetically predicted BMI and smoking. The sensitivity analysis did not reveal any evidence of horizontal pleiotropy or heterogeneity, thus supporting the validity of the study's results. Conclusions This MR investigation posits a potential causal nexus between daytime napping, sleep duration, and depression, and the genesis of CVDs, offering new perspectives on the prevention and management of CVDs.
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Affiliation(s)
- Yilin Li
- Department of Geriatrics, The Third People’s Hospital of Chengdu, Chengdu, China
| | - Parveen K. Garg
- Division of Cardiology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
| | - Jing Wu
- Department of Geriatrics, The Third People’s Hospital of Chengdu, Chengdu, China
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23
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Li L, Mei T. Partial sleep deprivation affects the athletic performance of Sanda athletes: An RCT study. Heliyon 2024; 10:e38879. [PMID: 39421376 PMCID: PMC11483289 DOI: 10.1016/j.heliyon.2024.e38879] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/24/2024] [Revised: 09/18/2024] [Accepted: 10/01/2024] [Indexed: 10/19/2024] Open
Abstract
This study explored the effects of partial sleep deprivation (PSD) on Sanda athletes' athletic performance, an area with limited research. Using a randomized crossover controlled trial with 18 male athletes, the PSD group had 4 h of sleep while the NSN group had 8 h. Results showed that after PSD intervention, the RAT time significantly increased compared to the NSN group (P = 0.0311). However, there was no significant change in CMJ (P = 0.2396) or YBT (left leg: P = 0.2767, right leg: P = 0.3225) between the PSD and NSN groups. In the Wingate test, the PSD group exhibited significant reductions in Pmax and Pave at 10s, 30s, and 60s (P<0.0001), as well as a significant decrease in Prel at 60s (P<0.0001), with no significant differences in Prel at 10s and 30s. These findings underscore the detrimental impact of limited sleep on anaerobic performance and agility in Sanda athletes, emphasizing the need for proper sleep management for optimal athletic outcomes.
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Affiliation(s)
- Liang Li
- Faculty of Sport Science and Coaching, Sultan Idris Education University, Tanjung Malin, Malaysia
- China Institute of Sport Science, Beijing Sport University, Beijing, China
| | - Tao Mei
- China Institute of Sport Science, Beijing Sport University, Beijing, China
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24
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van Duijne HM, Berentzen NE, Vermeulen RCH, Vlaanderen JJ, Kromhout H, Jóźwiak K, Pijpe A, Rookus MA, van Leeuwen FE, Schaapveld M. Associations of night shift work with weight gain among female nurses in The Netherlands: results of a prospective cohort study. Scand J Work Environ Health 2024; 50:536-544. [PMID: 39221466 PMCID: PMC11473151 DOI: 10.5271/sjweh.4185] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/31/2024] [Indexed: 09/04/2024] Open
Abstract
OBJECTIVE This study aimed to prospectively investigate associations of working night shifts with weight gain in the Nightingale Study, a large cohort of female nurses. METHODS This study included 36 273 registered nurses, who completed questionnaires in 2011 and 2017. Cumulative number of nights, mean number of nights/month and consecutive number of nights/month in 2007-2011 were assessed. We used Poisson regression to estimate multivariable-adjusted incidence rate ratios (IRR) of >5% weight gain from 2011 to 2017 among all participants and assess risk of development of overweight/obesity (BMI≥25 kg/m2) among women with healthy baseline body mass index. The reference group consisted of women who never worked nights. RESULTS Overall, working night shifts in 2007-2011 was associated with >5% weight gain [IRR 1.07, 95% confidence interval (CI) 1.01-1.13]. Associations differed by menopausal status in 2011, with an increased risk of gaining >5% weight limited to postmenopausal women who worked nights (IRR 1.23, 95% CI 1.10-1.38). Postmenopausal women had an increased risk of >5% weight gain when they worked on average ≥4 nights/month (4-5: IRR 1.29, 95% CI 1.09-1.52, ≥6: IRR 1.27, 95% CI 1.11-1.47) or ≥4 consecutive nights/month (IRR 1.37, 95% CI 1.19-1.58), compared to postmenopausal women who never worked nights. For postmenopausal women with healthy weight at baseline, night shift work was associated with an increased risk of overweight/obesity at follow-up (IRR 1.24, 95% CI 1.03-1.50). CONCLUSIONS Working night shifts was associated with a slightly increased risk of weight gain and overweight/obesity development among women who were postmenopausal at study inclusion. Our findings emphasize the importance of health promotion to maintain a healthy weight among (postmenopausal) night workers.
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Affiliation(s)
| | | | | | | | | | | | | | | | | | - Michael Schaapveld
- Department of Epidemiology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
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25
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Dashti HS. Sleep and home parenteral nutrition in adults: A narrative review. Nutr Clin Pract 2024; 39:1081-1093. [PMID: 38934221 DOI: 10.1002/ncp.11181] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/01/2024] [Revised: 04/24/2024] [Accepted: 06/07/2024] [Indexed: 06/28/2024] Open
Abstract
Infusions of home parenteral nutrition (HPN) are often cycled at night coinciding with sleep episodes. Adult consumers of HPN are known to experience poor sleep attributed to frequent awakenings and long durations of wakefulness after falling asleep. Consequently, most consumers do not meet recommendations for sleep duration and quality or daytime napping. The primary underlying pathophysiology resulting in sleep problems is nocturia; however, other factors also exist, including disruptions caused by medical equipment (ie, pump alarms), comorbid conditions, dysglycemia, and medication use. Early guidance on sleep is imperative because of the central role of sleep in physical health and wellbeing, including mitigating complications, such as infection risk, gastrointestinal problems, pain sensitivity, and fatigue. Clinicians should routinely inquire about the sleep of their patients and address factors known to perturb sleep. Nonpharmacologic opportunities to mitigate sleep problems include education on healthy sleep practices (ie, sleep hygiene); changes in infusion schedules, volumes, rates, and equipment; and, possibly, behavioral interventions, which have yet to be examined in this population. Addressing comorbid conditions, such as mood disorders, and nutrition deficiencies may also help. Pharmacologic interventions and technological advancement in HPN delivery are also needed. Research on sleep in this population is considered a priority, yet it remains limited at this time.
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Affiliation(s)
- Hassan S Dashti
- Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
- Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA
- Division of Nutrition, Harvard Medical School, Boston, Massachusetts, USA
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26
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Zhang L, Wang HX, Li WX, Zhu YY, Ma RR, Wang YH, Zhang Y, Zhu DM, Zhu P. Association of Maternal Short Sleep Duration With Neurodevelopmental Delay in Offspring: A Prospective Cohort Study. J Clin Endocrinol Metab 2024:dgae569. [PMID: 39324789 DOI: 10.1210/clinem/dgae569] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/09/2024] [Indexed: 09/27/2024]
Abstract
CONTEXT To investigate how short sleep duration (SSD) during pregnancy is related to neurodevelopmental delays in offspring, we aimed to inform pregnancy sleep guidelines and promote maternal health and child development. OBJECTIVE To identify the associations between SSD during pregnancy and offspring neurodevelopmental delay and to determine whether fetal glucose metabolism plays a role in SSD and neurodevelopmental delays. METHODS This cohort study followed 7059 mother-child pairs from the Maternal & Infants Health in Hefei cohort, and collected sleep data during pregnancy via the Pittsburgh Sleep Quality Index at weeks 24 to 28 and 32 to 36. Neurodevelopmental outcomes from 6 to 36 months postpartum were assessed via the Denver Developmental Screening Test-II and the Gesell Development Diagnosis Scale. Cox proportional hazard regression was used to analyze the link between maternal SSD and neurodevelopmental delay risk. Mediation analysis was used to evaluate the role of cord blood serum C-peptide levels. Three hospitals and children's health centers in Hefei were involved. RESULTS The stratified analysis revealed a significant association between mothers with SSD during midpregnancy and neurodevelopmental delay in boys (adjusted HR 2.05, 95% CI 1.29, 3.25). Cord blood marker analysis revealed a positive relationship between cord blood serum C-peptide levels and neurodevelopmental delay in offspring (RR 0.04, 95% CI 0.00, 0.08). The proportion of the association between SSD and neurodevelopmental delay mediated by cord blood C-peptide was 11.05%. CONCLUSION Maternal SSD during pregnancy was continuously associated with an increased incidence of neurodevelopmental delay with sex differences among offspring. This association may be mediated in part by increased higher levels of cord C-peptide.
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Affiliation(s)
- Lei Zhang
- Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China
- MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, Anhui 230032, China
- NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University, Hefei, Anhui 230032, China
- Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui 230032, China
| | - Hai-Xia Wang
- Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China
- MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, Anhui 230032, China
- NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University, Hefei, Anhui 230032, China
- Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui 230032, China
| | - Wen-Xiang Li
- Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China
| | - Yuan-Yuan Zhu
- Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China
- MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, Anhui 230032, China
- Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui 230032, China
| | - Rui-Rui Ma
- Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China
- MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, Anhui 230032, China
- Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui 230032, China
| | - Yu-Hong Wang
- Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China
- MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, Anhui 230032, China
- Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui 230032, China
| | - Yu Zhang
- Department of Sleep Disorders, Affiliated Psychological Hospital of Anhui Medical University, Hefei, Anhui 230032, China
- Hefei Fourth People's Hospital, Hefei, Anhui 230022, China
- Anhui Mental Health Center, Hefei, Anhui 230022, China
| | - Dao-Min Zhu
- Department of Sleep Disorders, Affiliated Psychological Hospital of Anhui Medical University, Hefei, Anhui 230032, China
- Hefei Fourth People's Hospital, Hefei, Anhui 230022, China
- Anhui Mental Health Center, Hefei, Anhui 230022, China
| | - Peng Zhu
- Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China
- MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, Anhui 230032, China
- NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University, Hefei, Anhui 230032, China
- Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui 230032, China
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27
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Popp KL, Bozzini BN, Reynoso M, Coulombe J, Guerriere KI, Proctor SP, Castellani CM, Walker LA, Zurinaga N, Kuhn K, Foulis SA, Bouxsein ML, Hughes JM, Santoro N. Hypothalamic-pituitary-ovarian axis suppression is common among women during US Army Basic Combat Training. Br J Sports Med 2024; 58:1052-1060. [PMID: 39043442 DOI: 10.1136/bjsports-2023-107716] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 07/10/2024] [Indexed: 07/25/2024]
Abstract
OBJECTIVE Less than half of servicewomen report loss of menses during initial military training. However, self-reported menstrual status may not accurately reflect hypothalamic-pituitary-ovarian (HPO) axis suppression and may underestimate reproductive health consequences of military training. Our aim was to characterise HPO axis function during US Army Basic Combat Training (BCT) in non-hormonal contraceptive-using women and explore potential contributors to HPO axis suppression. METHODS In this 10-week prospective observational study, we enrolled multi-ethnic women entering BCT. Trainees provided daily first-morning voided urine, and weekly blood samples during BCT. Urinary luteinising hormone, follicle stimulating hormone, and metabolites of estradiol and progesterone were measured by chemiluminescent assays (Siemens Centaur XP) to determine hormone patterns and luteal activity. We measured body composition, via dual-energy X-ray absorptiometry, at the beginning and end of BCT. RESULTS Trainees (n=55) were young (mean (95% CI): 22 (22, 23) years) with average body mass index (23.9 (23.1, 24.7) kg/m2). Most trainees (78%) reported regular menstrual cycles before BCT. During BCT, 23 (42%) trainees reported regular menses. However, only seven trainees (12.5%) had menstrual cycles with evidence of luteal activity (ELA) (ie, presumed ovulation), all with shortened luteal phases. 41 trainees (75%) showed no ELA (NELA), and 7 (12.5%) were categorised as indeterminant. Overall, women gained body mass and lean mass, but lost fat mass during BCT. Changes in body mass and composition appear unrelated to luteal activity. CONCLUSIONS Our findings reveal profound HPO axis suppression with NELA in the majority of women during BCT. This HPO axis suppression occurs among women who report normal menstrual cycles.
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Affiliation(s)
- Kristin L Popp
- Military Performance Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA
- TRIA Orthopaedic Center, HealthPartners Institute, Bloomington, Minnesota, USA
- Wu Tsai Female Athlete Program, Division of Sports Medicine, Boston Children's Hospital, Boston, Massachusetts, USA
| | - Brittany N Bozzini
- Military Performance Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA
| | - Marinaliz Reynoso
- Military Performance Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA
| | - Jennifer Coulombe
- Military Performance Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA
- Department of Orthopedic Surgery, Harvard Medical School and Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
| | - Katelyn I Guerriere
- Military Performance Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA
| | - Susan P Proctor
- Military Performance Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA
| | - Colleen M Castellani
- Military Performance Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA
| | - Leila A Walker
- Military Performance Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA
| | - Nicholas Zurinaga
- Military Performance Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA
| | - Katherine Kuhn
- Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA
| | - Stephen A Foulis
- Military Performance Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA
| | - Mary L Bouxsein
- Department of Orthopedic Surgery, Harvard Medical School and Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
- Endcrine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
| | - Julie M Hughes
- Military Performance Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA
| | - Nanette Santoro
- Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA
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28
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Souza JFT, Monico-Neto M, Tufik S, Antunes HKM. Sleep Debt and Insulin Resistance: What's Worse, Sleep Deprivation or Sleep Restriction? Sleep Sci 2024; 17:e272-e280. [PMID: 39268336 PMCID: PMC11390169 DOI: 10.1055/s-0044-1782173] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/13/2023] [Accepted: 10/05/2023] [Indexed: 09/15/2024] Open
Abstract
Objective To evaluate which condition of sleep debt has a greater negative impact on insulin resistance: sleep deprivation for 24 hours or 4 hours of sleep restriction for 4 nights. Materials and Methods In total, 28 healthy male subjects aged 18 to 40 years were recruited and randomly allocated to two groups: sleep deprivation (SD) and sleep restriction (SR). Each group underwent two conditions: regular sleep (11 pm to 7 am ) and total sleep deprivation for 24 hours (SD); regular sleep (11 pm to 7 am ) and 4 nights of sleep restriction (SR) (1 am to 5 am ). The oral glucose tolerance test (OGTT) was performed, and baseline glucose, insulin, free fatty acids (FFAs), and cortisol were measured. In addition, the area under the curve (AUC) for glucose and insulin, the homeostasis model assessment of insulin resistance (HOMA-IR), and the Matsuda Index (Insulin Sensitivity Index, ISI) were calculated. Results Glucose and insulin had a similar pattern between groups, except at the baseline, when insulin was higher in the sleep debt condition of the SR when compared with the SD ( p < 0.01). In the comparison between regular sleep and sleep debt, the SD had a higher insulin AUC ( p < 0.01) and FFAs ( p = 0.03) after sleep deprivation, and insulin and the insulin AUC increased ( p < 0.01 for both), while the ISI decreased ( p = 0.02) after sleep restriction in the SR. In baseline parameters covariate by the condition of regular sleep, insulin ( p = 0.02) and the HOMA-IR ( p < 0.01) were higher, and cortisol ( p = 0.04) was lower after sleep restriction when compared with sleep deprivation. Conclusion Sleep restriction for 4 consecutive nights is more detrimental to energy metabolism because of the higher insulin values and insulin resistance compared with an acute period of sleep deprivation of 24 hours.
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Affiliation(s)
- Jorge Fernando Tavares Souza
- Departamento de Psicobiologia, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil
| | - Marcos Monico-Neto
- Departamento de Psicobiologia, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil
| | - Sergio Tufik
- Departamento de Psicobiologia, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil
| | - Hanna Karen Moreira Antunes
- Departamento de Psicobiologia, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil
- Department of Biosciences, Instituto de Saúde e Sociedade (ISS), Universidade Federal de São Paulo (Unifesp), Santos, SP, Brazil
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Yuan Z, Wang Y, Du Z, Lin S, Zeng J, Sun X, Zhang Y, Deng X, Sun Y, Wei J, Zhang M, Sun J, Gu J, Zhang W, Hao Y. Association of long-term exposure to PM 2.5 and its chemical components with the reduced quality of sleep. Sleep Med 2024; 121:251-257. [PMID: 39024779 DOI: 10.1016/j.sleep.2024.07.007] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/21/2024] [Revised: 05/22/2024] [Accepted: 07/08/2024] [Indexed: 07/20/2024]
Abstract
Poor sleep quality is a widespread concern. While the influence of particle exposure on sleep disturbances has received considerable attention, research exploring other dimensions of sleep quality and the chemical components of the particles remains limited. We employed a marginal structural model to explore the association of long-term exposure to PM2.5 and its chemical components with poor sleep quality. The odds ratio (95 % CI) for poor sleep quality was 1.335 (1.292-1.378), 1.097 (1.080-1.113), 1.137 (1.100-1.174), 1.197 (1.156-1.240), and 1.124 (1.107-1.140) per IQR increase in the concentration of PM2.5, SO42-, NO3-, NH4+, and BC, respectively. The score (and 95 % CI) of sleep latency, use of sleep medication, habitual sleep efficiency, subjective sleep quality, and daytime dysfunction were affected by PM2.5, with an increase of 0.059 (0.050-0.069), 0.054 (0.049-0.059), 0.011 (0.008-0.014), 0.011 (0.005-0.018), and 0.026 (0.018-0.034) per IQR increase in PM2.5 concentrations, respectively. This study supports the association of long-term exposure to PM2.5 and its chemical components with poor sleep quality.
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Affiliation(s)
- Zhupei Yuan
- Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, China
| | - Ying Wang
- Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, China
| | - Zhicheng Du
- Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, China
| | - Shao Lin
- Department of Environmental Health Sciences, University at Albany, State University of New York, Rensselaer, NY, USA
| | - Jincai Zeng
- Department of Preventive Health, Dongguan People's Hospital, Dongguan, China
| | - Xurui Sun
- Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, China
| | - Yuqin Zhang
- Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, China
| | - Xinlei Deng
- Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
| | - Yongqing Sun
- Department of Ultrasound, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China
| | - Jing Wei
- Department of Atmospheric and Oceanic Science, Earth System Science Interdisciplinary Center, University of Maryland, College Park, MD, 20740, USA
| | - Man Zhang
- Department of nosocomial infection management, Beijing Ditan Hospital, Capital Medical University, Beijing, China
| | - Jie Sun
- Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, China
| | - Jing Gu
- Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, China
| | - Wangjian Zhang
- Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, China.
| | - Yuantao Hao
- Peking University Center for Public Health and Epidemic Preparedness & Response, Peking, China; Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, China.
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Sobol M, Błachnio A, Meisner M, Szyszkowska J, Jankowski KS. Sleep, circadian activity patterns and postpartum depression: A systematic review and meta-analysis of actigraphy studies. J Sleep Res 2024; 33:e14116. [PMID: 38095248 DOI: 10.1111/jsr.14116] [Citation(s) in RCA: 3] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/28/2023] [Revised: 10/15/2023] [Accepted: 11/14/2023] [Indexed: 01/16/2024]
Abstract
Transition to motherhood is a period full of challenges and demands. In this review, we focused on the associations of sleep and circadian activity patterns during and after pregnancy with postpartum mental health factors. A systematic review and meta-analysis were conducted (PROSPERO reference 316,505). A search for articles was performed using PsycARTICLES, PsycINFO, PubMed, MEDLINE, Scopus, Cochrane, DARE, hand search, and citation tracking. The search was meant to identify peer-reviewed, experimental and observational studies reporting on women over 18 years old that assessed sleep and circadian activity patterns during pregnancy or postpartum using actigraphy, and investigated postpartum mental health factors. Nineteen relevant publications were selected. Postpartum total sleep at night was the indicator that was most closely related to the psychological functioning of women after childbirth. The results of the systematic review indicated that postpartum total sleep at night was related to postpartum fatigue, and the results of the meta-analysis suggested that total sleep at night was most strongly linked with postpartum depression. More studies are needed to estimate the associations of sleep-wake rhythm during pregnancy and in the postpartum period with postpartum mental health factors.
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Affiliation(s)
| | - Agata Błachnio
- Department of Psychology, Catholic University of Lublin, Lublin, Poland
| | - Michał Meisner
- Department of Psychology, University of Warsaw, Warsaw, Poland
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Hariri M, Shamshirgaran SM, Amini A, Abasi H, Gholami A. Sleep duration and quality are associated with health-related quality of life in adults aged 60 years and older. Ir J Med Sci 2024; 193:1929-1937. [PMID: 38489125 DOI: 10.1007/s11845-024-03656-y] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/25/2023] [Accepted: 02/27/2024] [Indexed: 03/17/2024]
Abstract
BACKGROUND The current study aimed to determine the association between sleep duration and quality with health-related quality of life (HRQoL) among the Iranian older persons. METHODS This study was conducted on a representative sample of 3452 Iranian older people (≥ 60 years) who participated in the Iranian Longitudinal Study on Ageing (IRLSA) launched in Neyshabur (Razavi Khorasan province, northeastern Iran). The Persian versions of 12-Item Short Form Survey (SF-12) and Pittsburgh Sleep Quality Index (PSQI) were utilized to measure the level of HRQoL and the level of sleep duration and quality, respectively. Multiple linear regression model was performed to analyze the data and clarify the independent association of sleep duration and quality with HRQoL. RESULTS More than half of the study population (52.4%) suffered from poor sleep quality. 57.3% and 3.9% of individuals were short sleepers (< 7 h) and long sleepers (equal or more than 9 h), respectively. The total score of HRQoL was achieved 65.87 ± 20.55. After adjusting the covariates, the results indicated that short sleep duration was negatively associated with HRQoL (P < 0.05), whereas no significant associations were found between long sleep duration and HRQoL (P > 0.05). Interestingly, the results of multiple linear regression model revealed a significant negative association between poor sleep quality and HRQoL (P < 0.001). CONCLUSION The current study confirmed that short sleep duration and poor sleep quality were independently associated with lower HRQoL in the older persons. Therefore, interventional courses should be planned to enrich sleep-related healthcare and general HRQoL in the older persons.
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Affiliation(s)
- Mitra Hariri
- Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran
| | - Seyed Morteza Shamshirgaran
- Healthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, Iran
- Department of Epidemiology and Biostatistics, School of Public Health, Neyshabur University of Medical Sciences, Neyshabur, Iran
| | - Asieh Amini
- Department of English Language Teaching, Razi University, Kermanshah, Iran
| | - Hamid Abasi
- Public Health Department, Neyshabur University of Medical Sciences, Neyshabur, Iran
| | - Ali Gholami
- Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.
- Department of Epidemiology and Biostatistics, School of Public Health, Neyshabur University of Medical Sciences, Neyshabur, Iran.
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Ou M, Xue Y, Qin Y, Zhang X. Experience and caring needs of patients with psoriasis: A qualitative meta-synthesis. J Clin Nurs 2024; 33:3294-3317. [PMID: 38616578 DOI: 10.1111/jocn.17146] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/07/2023] [Revised: 01/26/2024] [Accepted: 02/05/2024] [Indexed: 04/16/2024]
Abstract
BACKGROUND As a chronic skin disease, psoriasis often affects the physical, psychological and social status of the patient, which in turn impacts on their experience of illness and needs. However, there is no review of qualitative research that integrates and analyses the experiences and needs of these three influences from a holistic perspective. METHODS This review follows the ENTREQ guidelines. Six English databases (JBI, Cochrane Library, PubMed, PsyINFO, CINAHL and Embase) and three Chinese databases (CNKI, VIP and Wanfang) were searched from January 2012 to October 2022. Literature was included if it was relevant to the experience of illness and caring needs of patients with psoriasis. The JBI-QARI was used to rate the quality of included studies. RESULTS Eleven studies were included in the meta-synthesis. Four analytical themes were identified for analysis: physical challenges, psychological discomfort, social phenomena and caring needs. CONCLUSIONS The combined physical, psychological and social effects of psoriasis and the consequent caring needs should be emphasised. Health professionals, including doctors and nurses, should be aware of the multiple changes in patients and their coping strategies, provide information about psoriasis, monitor and follow-up regularly over time and obtain feedback to inform further treatment and care so as to develop high-quality therapeutic interventions to help and guide patients with their coping strategies. RELEVANCE TO CLINICAL PRACTICE These findings describe the physical, psychological and social experiences of illness and caring needs of patients with psoriasis. Healthcare professionals should be more aware of patients' easily overlooked psychological and social distress, providing prompt attention and recognition of patients' experiences and needs, offering relevant assistance and support and enhancing daily, regular follow-up to help them improve their understanding of and ability to manage their illness. NO PATIENT OR PUBLIC CONTRIBUTION This is a meta-synthesis without direct patient involvement.
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Affiliation(s)
- Minxing Ou
- Department of Dermatology, First Affiliated Hospital of Dalian Medical University, Dalian, China
| | - Yanan Xue
- Department of Dermatology, First Affiliated Hospital of Dalian Medical University, Dalian, China
| | - Yiyi Qin
- Department of Psychology, Harbin Medical University, Harbin, China
| | - Xiujie Zhang
- Department of Dermatology, First Affiliated Hospital of Dalian Medical University, Dalian, China
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Liu J, Gao Y, Ye N, He X, Zhang J. Association of sleep duration with Visceral Adiposity Index: a cross-sectional study based on the NHANES 2007-2018. BMJ Open 2024; 14:e082601. [PMID: 39019627 PMCID: PMC11407204 DOI: 10.1136/bmjopen-2023-082601] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/30/2023] [Accepted: 05/31/2024] [Indexed: 07/19/2024] Open
Abstract
OBJECTIVE We aimed to assess the associations between sleep duration and Visceral Adiposity Index (VAI). DESIGN Cross-sectional study. SETTING The National Health and Nutrition Examination Survey (2007-2018). PARTICIPANTS A total 11 252 eligible participants who have complete information for sleep duration and VAI. OUTCOME MEASURE The VAI index, which is sex-specific and takes into consideration factors such as waist circumference, body mass index, high-density lipoprotein cholesterol and triglycerides, was calculated in accordance with prior research. Multiple linear regressions and subgroup analyses were employed to evaluate the connection between the duration of sleep and the VAI. RESULTS The mean sleep duration and VAI of included participants were 7.05 hours/day and 2.03, respectively. After adjusting for the sociodemographic, lifestyle and other covariates, short sleep was significantly linked to increased VAI (β=0.15, 95% CI 0.01 to 0.28) in relation to middle sleep duration, whereas no significant association was found between long sleep duration and VAI. An L-shaped relationship was observed between sleep duration and VAI. When sleep duration was less than 7.5 hours/day, a negative association between sleep duration and VAI was obvious. However, when sleep duration was >7.5 hours/day, VAI was increased with a longer sleep duration, although it was not significant. CONCLUSIONS An L-shaped relationship was observed between sleep duration and VAI, with insufficient sleep, being independently linked to a higher VAI. This implies that sleep deprivation might be associated with visceral adipose distribution and disfunction.
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Affiliation(s)
- Juan Liu
- Department of Nursing, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Zhejiang University School of Medicine, Hangzhou, China
| | - Yajie Gao
- Zhejiang University School of Medicine, Hangzhou, China
| | - Nan Ye
- Zhejiang University School of Medicine, Hangzhou, China
| | - Xingkang He
- Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University Medical School, Zhejiang University School of Medicine, Hangzhou, China
| | - Jing Zhang
- Second Department of Infectious Disease, Fifth People's Hospital of Shanghai Fudan University, Shanghai, China
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Tonet NS, da Silva Marçal DF, da Silva FN, Brunetta HS, Mori MADS, Dos Santos GJ, Moreira ELG, Rafacho A. Moderate chronic sleep perturbation impairs glucose and lipid homeostasis in rats. Sleep 2024; 47:zsae118. [PMID: 38788154 DOI: 10.1093/sleep/zsae118] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/27/2024] [Revised: 04/23/2024] [Indexed: 05/26/2024] Open
Abstract
STUDY OBJECTIVES Sleep deprivation is a potential risk factor for metabolic diseases, including obesity and type 2 diabetes. We evaluated the impacts of moderate chronic sleep deprivation on glucose and lipid homeostasis in adult rats. METHODS Wistar rats (both sexes) were sleep-perturbed daily for 2 hours at the early (06:00-08:00) and the late light cycle (16:00-18:00) five days a week (except weekends) for 4 weeks. RESULTS Sleep perturbation (SP) resulted in reduced body weight gain in both sexes, associated with altered food intake and reduced adiposity. SP did not alter the short- or long-term memories or cause anxiogenic behavior. No major changes were observed in the plasma insulin, leptin, triacylglycerol, non-esterified fatty acids, and blood glucose upon SP. After SP, females exhibited a transitory glucose intolerance, while males became glucose intolerant at the end of the experimental period. Male rats also developed higher insulin sensitivity at the end of the SP protocol. Morphometric analyses revealed no changes in hepatic glycogen deposition, pancreatic islet mass, islet-cell distribution, or adrenal cortex thickness in SP rats from both sexes, except for lower adipocyte size compared with controls. We did not find homogeneous changes in the relative expression of circadian and metabolic genes in muscle or hepatic tissues from the SP rats. CONCLUSIONS Moderate chronic SP reduces visceral adiposity and causes glucose intolerance with a more pronounced impact on male rats, reinforcing the metabolic risks of exposure to sleep disturbances.
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Affiliation(s)
- Natália Stinghen Tonet
- Laboratory of Investigation in Chronic Diseases (LIDoC), Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil
- Graduate Program in Biochemistry, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil
| | - Danilo Francisco da Silva Marçal
- Laboratory of Investigation in Chronic Diseases (LIDoC), Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil
| | - Flavia Natividade da Silva
- Laboratory of Investigation in Chronic Diseases (LIDoC), Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil
| | - Henver Simionato Brunetta
- Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, Brazil
| | - Marcelo Alves da Silva Mori
- Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, Brazil
| | - Gustavo Jorge Dos Santos
- Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil
| | - Eduardo Luiz Gasnhar Moreira
- Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil
| | - Alex Rafacho
- Laboratory of Investigation in Chronic Diseases (LIDoC), Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil
- Graduate Program in Biochemistry, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil
- Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil
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Marquardt M, Pontis S. A Mixed-Methods, Multimedia Pilot Study to Investigate Sleep Irregularity Determinants Among Undergraduate Students. Am J Health Promot 2024; 38:852-863. [PMID: 38513650 DOI: 10.1177/08901171241240818] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 03/23/2024]
Abstract
PURPOSE To pilot a novel approach investigating the interplay of social and institutional determinants influencing university undergraduate student sleep patterns. DESIGN A two-part, three-phase mixed-methods approach. SETTING A mid-size US university conducted in spring and fall 2020. PARTICIPANTS 191 undergraduate students (69 first-years, 43 second-years, 48 third-years, 31 fourth-years). METHOD For Part A, participants texted their activities and emotions in real time, producing a data-rich, weeklong diary of comprehensive activity logs, emoticons, multimedia submissions, and juxtapositions of ideal vs real schedules. Semi-structured contextual interviews were also conducted. For Part B, a one-time survey examined Part A insights across all class years. These diverse datasets were triangulated using thematic, comparative, and content analyses through MAXQDA software and visual mapping methods. RESULTS Three preliminary themes were identified as encouraging an irregular sleep schedule: a prevailing academic ethos emphasizing busyness, time management challenges, and the rhythm of institutional schedules and deadlines. An overarching theme suggests that perceptions of peer sleep habits and academic prioritization above all else could be influential across factors. CONCLUSION This pilot study indicates that sleep regularity among undergraduates is potentially shaped by individual choices combined with broader institutional paradigms. While it is limited by its exploratory nature, timing, and small sample size, the results highlight the promise of this methodology for more extensive studies and suggest that future interventions should emphasize systemic changes that prioritize sleep.
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Affiliation(s)
| | - Sheila Pontis
- Integrated Design and Management, Massachusetts Institute of Technology, Cambridge, MA, USA
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Yano J, Nave C, Larratt K, Honey P, Roberts M, Jingco C, Fung ML, Trotter D, He X, Elezi G, Whitelegge JP, Wasserman S, Donlea JM. Elevated sleep quota in a stress-resilient Drosophila species. Curr Biol 2024; 34:2487-2501.e3. [PMID: 38772361 PMCID: PMC11163955 DOI: 10.1016/j.cub.2024.04.060] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/26/2023] [Revised: 01/09/2024] [Accepted: 04/25/2024] [Indexed: 05/23/2024]
Abstract
Sleep is broadly conserved across the animal kingdom but can vary widely between species. It is currently unclear which selective pressures and regulatory mechanisms influence differences in sleep between species. The fruit fly Drosophila melanogaster has become a successful model system for examining sleep regulation and function, but little is known about the sleep patterns in many related fly species. Here, we find that fly species with adaptations to extreme desert environments, including D. mojavensis, exhibit strong increases in baseline sleep compared with D. melanogaster. Long-sleeping D. mojavensis show intact homeostasis, indicating that desert flies carry an elevated drive for sleep. In addition, D. mojavensis exhibit altered abundance or distribution of several sleep/wake-related neuromodulators and neuropeptides that are consistent with their reduced locomotor activity and increased sleep. Finally, we find that in a nutrient-deprived environment, the sleep patterns of individual D. mojavensis are strongly correlated with their survival time and that disrupting sleep via constant light stimulation renders D. mojavensis more sensitive to starvation. Our results demonstrate that D. mojavensis is a novel model for studying organisms with high sleep drive and for exploring sleep strategies that provide resilience in extreme environments.
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Affiliation(s)
- Jessica Yano
- Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; Molecular, Cellular & Integrative Physiology Interdepartmental PhD Program, UCLA, Los Angeles, CA 90095, USA
| | - Ceazar Nave
- Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
| | - Katherine Larratt
- Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
| | - Phia Honey
- Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; Department of Neuroscience, Wellesley College, Wellesley, MA 02481, USA
| | - Makayla Roberts
- Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
| | - Cassandra Jingco
- Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
| | - Melanie L Fung
- Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
| | - Damion Trotter
- Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; Molecular, Cellular & Integrative Physiology Interdepartmental PhD Program, UCLA, Los Angeles, CA 90095, USA
| | - Xin He
- Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
| | - Gazmend Elezi
- Pasarow Mass Spectrometry Laboratory, Jane & Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; Cotsen Institute of Archaeology, UCLA, Los Angeles, CA 90095, USA
| | - Julian P Whitelegge
- Pasarow Mass Spectrometry Laboratory, Jane & Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
| | - Sara Wasserman
- Department of Neuroscience, Wellesley College, Wellesley, MA 02481, USA
| | - Jeffrey M Donlea
- Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
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Pettit RJ, Gregory B, Stahl S, Buller LT, Deans C. Total Joint Arthroplasty and Sleep: The State of the Evidence. Arthroplast Today 2024; 27:101383. [PMID: 39071825 PMCID: PMC11282419 DOI: 10.1016/j.artd.2024.101383] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/05/2023] [Revised: 03/01/2024] [Accepted: 03/18/2024] [Indexed: 07/30/2024] Open
Abstract
Background As the number of total hip and knee arthroplasties (TJA) performed increases, there is heightened interest in perioperative optimization to improve outcomes. Sleep is perhaps one of the least understood perioperative factors that affects TJA outcomes. The purpose of this article is to review the current body of knowledge regarding sleep and TJA and the tools available to optimize sleep perioperatively. Methods A manual search was performed using PubMed for articles with information about sleep in the perioperative period. Articles were selected that examined: sleep and pain in the perioperative period; the effect of surgery on sleep postoperatively; the relationship between sleep and TJA outcomes; risk factors for perioperative sleep disturbance; the effect of anesthesia on sleep; and the efficacy of interventions to optimize sleep perioperatively. Results Sleep and pain are intimately associated; poor sleep is associated with increased pain sensitivity. Enhanced sleep is associated with improved surgical outcomes, although transient sleep disturbances are normal postoperatively. Risk factors for perioperative sleep disturbance include increasing age, pre-existing sleep disorders, medical comorbidities, and type of anesthesia used. Interventions to improve sleep include optimizing medical comorbidities preoperatively, increasing sleep time perioperatively, appropriating sleep hygiene, using cognitive behavioral therapy, utilizing meditation and mindfulness interventions, and using pharmacologic sleep aids. Conclusions Sleep is one of many factors that affect TJA. As we better understand the interplay between sleep, risk factors for suboptimal sleep, and interventions that can be used to optimize sleep, we will be able to provide better care and improved outcomes for patients.
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Affiliation(s)
- Robert J. Pettit
- Department of Orthopaedic Surgery & Rehabilitation, University of Nebraska School of Medicine, Omaha, NE, USA
| | - Brandon Gregory
- Department of Orthopaedic Surgery, Saint Louis University School of Medicine, Saint Louis, MO, USA
| | - Stephanie Stahl
- Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
| | - Leonard T. Buller
- Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
| | - Christopher Deans
- Department of Orthopaedic Surgery & Rehabilitation, University of Nebraska School of Medicine, Omaha, NE, USA
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Matricciani L, Dumuid D, Stanford T, Maher C, Bennett P, Bobrovskaya L, Murphy A, Olds T. Time use and dimensions of healthy sleep: A cross-sectional study of Australian children and adults. Sleep Health 2024; 10:348-355. [PMID: 38199899 DOI: 10.1016/j.sleh.2023.10.012] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/13/2023] [Revised: 09/12/2023] [Accepted: 10/24/2023] [Indexed: 01/12/2024]
Abstract
BACKGROUND Sleep is increasingly recognized as a multidimensional construct that occurs within the 24-hour day. Despite advances in our understanding, studies continue to consider the relationship between sleep, sedentary time and physical activity separately, and not as part of the 24-hour day. AIMS To determine the association between the 24-hour activity composition and dimensions of healthy sleep. METHODS This study examined data on 1168 children (mean age 12years; 49% female) and 1360 adults (mean age 44years; 87% female) collected as part of the Child Health CheckPoint study. Participants were asked to wear a GENEActiv monitor (Activinsights, Cambs, UK) on their nondominant wrist for eight consecutive days to measure 24-hour time-use. Compositional data analysis was used to examine the association between time use (actigraphy-derived sleep duration, sedentary time, light physical activity and moderate-vigorous physical activity) and dimensions of healthy sleep. Healthy sleep was conceptualized in terms of continuity/efficiency, timing, alertness/sleepiness, satisfaction/quality, and regularity. Time allocations were also examined. RESULTS The 24-hour activity composition was significantly associated with all objectively measured and self-report dimensions of healthy sleep in both children and adults. Allocating more time to sleep was associated with earlier sleep onsets, later sleep offsets, less efficient and more consistent sleep patterns for both children and adults. CONCLUSION This study highlights the integral relationship between daily activities and dimensions of sleep. Considering sleep within the 24-hour day activity composition framework may help inform lifestyle decisions to improve sleep health.
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Affiliation(s)
- Lisa Matricciani
- Clinical & Health Sciences, University of South Australia, Adelaide, South Australia, Australia; Alliance for Research in Exercise, Nutrition and Activity (ARENA), University of South Australia, Adelaide, South Australia, Australia; Rosemary Bryant AO Research Centre, University of South Australia, Adelaide, South Australia, Australia.
| | - Dorothea Dumuid
- Alliance for Research in Exercise, Nutrition and Activity (ARENA), University of South Australia, Adelaide, South Australia, Australia; Allied Health and Human Performance (AHHP), University of South Australia, Adelaide, South Australia, Australia; Murdoch Children's Research Institute, Parkville, Victoria, Australia
| | - Ty Stanford
- Clinical & Health Sciences, University of South Australia, Adelaide, South Australia, Australia; Alliance for Research in Exercise, Nutrition and Activity (ARENA), University of South Australia, Adelaide, South Australia, Australia
| | - Carol Maher
- Alliance for Research in Exercise, Nutrition and Activity (ARENA), University of South Australia, Adelaide, South Australia, Australia; Allied Health and Human Performance (AHHP), University of South Australia, Adelaide, South Australia, Australia
| | - Paul Bennett
- School of Nursing and Midwifery, Griffith Health, Griffith University, Brisbane, Queensland, Australia
| | - Larisa Bobrovskaya
- Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia
| | - Andrew Murphy
- Allied Health and Human Performance (AHHP), University of South Australia, Adelaide, South Australia, Australia
| | - Tim Olds
- Alliance for Research in Exercise, Nutrition and Activity (ARENA), University of South Australia, Adelaide, South Australia, Australia; Allied Health and Human Performance (AHHP), University of South Australia, Adelaide, South Australia, Australia; Murdoch Children's Research Institute, Parkville, Victoria, Australia
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Arab A, Karimi E, Garaulet M, Scheer FAJL. Dietary patterns and insomnia symptoms: A systematic review and meta-analysis. Sleep Med Rev 2024; 75:101936. [PMID: 38714136 PMCID: PMC11179690 DOI: 10.1016/j.smrv.2024.101936] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/02/2024] [Revised: 03/18/2024] [Accepted: 03/25/2024] [Indexed: 05/09/2024]
Abstract
We aimed to systematically review and synthesize the available evidence regarding the link between dietary patterns and insomnia symptoms among the general population using observational studies. We reviewed 16,455 references, of which 37 studies met inclusion criteria with a total sample size of 591,223. There was a significant association of the Mediterranean diet (OR: 0.86; 95 % CI, 0.79, 0.93; P < 0.001; I2 = 32.68 %), a high-quality diet (OR: 0.66; 95 % CI, 0.48, 0.90; P = 0.010; I2 = 84.62 %), and an empirically-derived healthy dietary pattern (OR: 0.91; 95 % CI, 0.85, 0.98; P = 0.010; I2 = 57.14 %) with a decreased risk of insomnia symptoms. Moreover, the dietary glycemic index (OR: 1.16; 95 % CI, 1.08, 1.25; P < 0.001; I2 = 0.0 %), the dietary glycemic load (OR: 1.10; 95 % CI, 1.01, 1.20; P = 0.032; I2 = 74.36 %), and an empirically-derived unhealthy dietary pattern (OR: 1.20; 95 % CI, 1.01, 1.42; P = 0.040; I2 = 68.38 %) were linked with a higher risk of insomnia symptoms. Most individual studies were of good quality (NOS) but provided very low certainty of evidence (GRADE). Consistent data reveals that following healthy diets is associated with decreased insomnia symptoms prevalence, while adherence to an unhealthy pattern is associated with an increased prevalence of insomnia symptoms.
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Affiliation(s)
- Arman Arab
- Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA; Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.
| | - Elham Karimi
- Research Development Center, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran.
| | - Marta Garaulet
- Department of Physiology, Regional Campus of International Excellence, University of Murcia, Murcia, Spain; Biomedical Research Institute of Murcia, IMIB-Arrixaca-UMU, University Clinical Hospital, Murcia, Spain.
| | - Frank A J L Scheer
- Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA; Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.
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Warren JR, Link RC, Cheng AL, Sinclair MK, Sorensen AA. Carpal tunnel syndrome and sleep, a systematic review and meta-analysis. HAND SURGERY & REHABILITATION 2024; 43:101698. [PMID: 38641062 DOI: 10.1016/j.hansur.2024.101698] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 12/10/2023] [Revised: 03/28/2024] [Accepted: 04/02/2024] [Indexed: 04/21/2024]
Abstract
BACKGROUND The most common symptom and reason patients seek treatment for carpal tunnel syndrome is lack of sleep. Our purpose was to determine how much sleep-related symptoms of carpal tunnel syndrome improve after carpal tunnel release using validated patient-reported outcome measures (PROMs) and objective sleep data as primary measures of interest. METHODS A PRISMA-guided literature search was conducted using Ovid MEDLINE, PubMed, Cochrane, and ClinicalTrials.gov. Only interventional clinical trials that examined primary outcome measures of interest were included. Patient-reported outcome measures underwent meta-analysis to determine how much scores improved following carpal tunnel release. RESULTS The Pittsburgh Sleep Quality Index improved significantly after carpal tunnel release, by 4.43 points and 6.02 points at 1-3 and 6-12 months postoperatively, respectively, and continued to improve up to 2 years. Improvement on the Insomnia Severity Index after carpal tunnel release was also significant, with improvement up to 1 year postoperatively, by 8.54 points and 9.05 points at 1-3 and 6-12 months, respectively. Insomnia Severity Index scores improved significantly after splinting as well. CONCLUSIONS The present meta-analysis determined to what extent patients can expect their sleep to improve after operative and non-operative intervention, as measured by various patient-reported outcome measures that assess sleep. The Pittsburgh Sleep Quality Index and Insomnia Severity Index correlated very well between studies and across hundreds of patients with carpal tunnel syndrome. Data are lacking to define the minimal clinically important difference and assess whether patients achieve a minimal clinically important difference for sleep questionnaires; more information on this topic is needed. LEVEL OF EVIDENCE III.
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Affiliation(s)
- Jonathan R Warren
- Department of Orthopaedic Surgery, University of Missouri Kansas City, 2301 Holmes St. Kansas City, MO 64063, USA.
| | - R Clayton Link
- Department of Orthopaedic Surgery, University of Missouri Kansas City, 2301 Holmes St. Kansas City, MO 64063, USA
| | - An-Lin Cheng
- Department of Orthopaedic Surgery, University of Missouri Kansas City, 2301 Holmes St. Kansas City, MO 64063, USA
| | - Micah K Sinclair
- Department of Orthopaedic Surgery, University of California Davis, 4860 Y St #1700, Sacramento, CA 95817, USA
| | - Amelia A Sorensen
- Department of Orthopaedic Surgery, University of Missouri Kansas City, 2301 Holmes St. Kansas City, MO 64063, USA
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Lok R, Qian J, Chellappa SL. Sex differences in sleep, circadian rhythms, and metabolism: Implications for precision medicine. Sleep Med Rev 2024; 75:101926. [PMID: 38564856 DOI: 10.1016/j.smrv.2024.101926] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/11/2023] [Revised: 02/16/2024] [Accepted: 03/18/2024] [Indexed: 04/04/2024]
Abstract
The number of individuals experiencing sleep loss has exponentially risen over the past decades. Extrapolation of laboratory findings to the real world suggests that females are more affected by extended wakefulness and circadian misalignment than males are. Therefore, long-term effects such as sleep and metabolic disorders are likely to be more prevalent in females than in males. Despite emerging evidence for sex differences in key aspects of sleep-wake and circadian regulation, much remains unknown, as females are often underrepresented in sleep and circadian research. This narrative review aims at highlighting 1) how sex differences systematically impinge on the sleep-wake and circadian regulation in humans, 2) how sex differences in sleep and circadian factors modulate metabolic control, and 3) the relevance of these differences for precision medicine. Ultimately, the findings justify factoring in sex differences when optimizing individually targeted sleep and circadian interventions in humans.
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Affiliation(s)
- Renske Lok
- Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
| | - Jingyi Qian
- Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Females's Hospital, Boston, MA, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA
| | - Sarah L Chellappa
- School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, United Kingdom.
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Apessos I, Lillis T, Voulgaris A, Archontogeorgis K, Steiropoulos P, Dabarakis N. Effect of Third Molar Surgery on Sleep Health Parameters of Young Adults: An Observational Study. MEDICINA (KAUNAS, LITHUANIA) 2024; 60:858. [PMID: 38929475 PMCID: PMC11206086 DOI: 10.3390/medicina60060858] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 04/06/2024] [Revised: 05/22/2024] [Accepted: 05/23/2024] [Indexed: 06/28/2024]
Abstract
Background and Objectives: The role of surgical extraction of the third molar in patients' sleep quality remains unclear, although it is one of the most common oral surgical procedures. The aim of this study is to assess the changes in patient-reported sleep health outcomes after third molar surgery and to investigate any associations between sleep parameters and post-extraction pain. Materials and Methods: Young adults without known comorbidities who were in need of mandibular third molar surgical extraction were included. All participants completed a sleep diary, the Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI) and Athens Insomnia Scale (AIS) questionnaires, which were used to assess sleep habits, daytime sleepiness, sleep quality and insomnia severity one week before and after extraction. In addition, a visual analog scale was completed postoperatively to assess the perception of pain. Results: Out of 75 patients who completed the study protocol, 32 (42.7%) were males and 43 (57.3%) were females, with a mean age of 24.01 (±3.43) years. Postoperatively, statistically significant higher scores were observed for PSQI [4.85 (±2.32) before vs. 5.39 (±2.75) after, p = 0.041], AIS [5.56 (±3.23) before vs. 6.91 (±4.06) after, p < 0.001] and average weekly number of nocturnal awakenings [2.01 (±3.72) before vs. 4.19 (±5.20) after, p < 0.001] but not for ESS, average weekly sleep duration and average weekly sleep onset latency. Pain perception was increased in patients who slept worse on almost all seven postoperative days, although this did not reach statistical significance. Conclusions: Third molar surgery impacts sleep quality and insomnia severity in the first week after extraction, while there is no effect on daytime sleepiness. The worsening of subjective sleep symptoms after extraction may be associated with an increased perception of pain.
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Affiliation(s)
- Ioulianos Apessos
- Department of Dentoalveolar Surgery, Implantology and Oral Radiology, School of Dentistry, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece; (T.L.); (N.D.)
- Division of Dentistry, 424 General Military Training Hospital, 56429 Thessaloniki, Greece
| | - Theodoros Lillis
- Department of Dentoalveolar Surgery, Implantology and Oral Radiology, School of Dentistry, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece; (T.L.); (N.D.)
| | - Athanasios Voulgaris
- Department of Pneumonology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece; (A.V.); (K.A.); (P.S.)
| | - Kostas Archontogeorgis
- Department of Pneumonology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece; (A.V.); (K.A.); (P.S.)
| | - Paschalis Steiropoulos
- Department of Pneumonology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece; (A.V.); (K.A.); (P.S.)
| | - Nikolaos Dabarakis
- Department of Dentoalveolar Surgery, Implantology and Oral Radiology, School of Dentistry, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece; (T.L.); (N.D.)
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Xu P, Wei Y, Wu H, Zhang L. Genetic associations between Rapid Eye Movement (REM) sleep behavior disorder and cardiovascular diseases. PLoS One 2024; 19:e0301112. [PMID: 38771893 PMCID: PMC11108173 DOI: 10.1371/journal.pone.0301112] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/26/2023] [Accepted: 03/11/2024] [Indexed: 05/23/2024] Open
Abstract
BACKGROUND Previous studies revealed that sleep disorders are potential risk factors for cardiovascular diseases, such as obstructive sleep apnea and rapid eye movement (REM) sleep behavior disorder (RBD). However, the causal associations between RBD and cardiovascular diseases remained unknown. MATERIALS AND METHODS We used the latest and largest summary-level genome-wide association studies of RBD, stroke and its subtypes, coronary artery disease (CAD), myocardial infarction (MI), and heart failure (HF) to select genetic variants as the instrumental variables. Mendelian randomization (MR) analysis was performed to test the causal associations between RBD and the cardiovascular diseases above. Inverse variance weighted method was used as the main analysis. RESULTS After multiple comparisons, genetically predicted RBD was significantly associated with the risk of HF [odds ratio (OR) = 1.033, 95% CI 1.013-1.052, p = 0.001]. Leave-one-out analysis further supported the robustness of the causal association. Furthermore, we identified a suggestive association between genetically predicted MI and RBD (OR = 0.716, 95% CI 0.546-0.940, p = 0.016). However, in our study no associations were identified of RBD with CAD or stroke and its subtypes. CONCLUSION Our study highlighted the potential associations between RBD and cardiovascular diseases at genetic level, including HF and MI. More studies were required to clarify the biological mechanisms involved the associations.
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Affiliation(s)
- Pengfei Xu
- Department of Neurosurgery, Nanyang Central Hospital, Nanyang, Henan, China
| | - Yitong Wei
- Department of Neurosurgery, Nanyang Central Hospital, Nanyang, Henan, China
| | - Haibo Wu
- Department of Neurology, Nanyang Central Hospital, Nanyang, Henan, China
| | - Li Zhang
- Department of Neurology, Nanyang Central Hospital, Nanyang, Henan, China
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Morgan T, Basalely A, Singer P, Castellanos L, Sethna CB. The association between sleep duration and cardiometabolic risk among children and adolescents in the United States (US): A NHANES study. Child Care Health Dev 2024; 50:e13273. [PMID: 38738838 DOI: 10.1111/cch.13273] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/31/2023] [Revised: 04/16/2024] [Accepted: 04/24/2024] [Indexed: 05/14/2024]
Abstract
PURPOSE This work aims to assess the association of sleep duration with cardiometabolic risk (adiposity, blood pressure, lipids, albuminuria and A1C) and to investigate lifestyle factors (physical activity, light exposure, caffeine consumption and sugar consumption) associated with sleep duration in children. METHODS A nationally representative sample of 3907 children ages 6-17 years enrolled in NHANES from 2011 to 2014 was included in this cross-sectional study. Sleep duration was defined as the daily average time spent sleeping over 7 days as measured by a physical activity monitor (PAM). Participants without valid sleep data for ≥95% of the study were excluded. Regression models were adjusted for age, sex, race, body mass index (BMI) Z score, physical activity and light exposure. RESULTS In adjusted regression models, longer sleep duration was associated with lower systolic blood pressure index (β = -3.63 * 10-5, 95% CI -6.99 * 10-5, -2.78 * 10-6, p = 0.035) and BMI Z score (β = -0.001, 95% CI -0.001, 0.000, p = 0.002). In logistic regression models, longer sleep duration was associated with lower odds of obesity (OR = 0.998, 95% CI 0.997, 0.999, p < 0.001) and overweight status (OR = 0.998, 95% CI 0.997, 0.999, p = 0.004). Greater light exposure (β = 6.64 * 10-5, 95% CI 3.50 * 10-5, 9.69 * 10-5, p < 0.001) and physical activity (β = 0.005, 95% CI 0.004, 0.006, p < 0.001) were associated with longer sleep. CONCLUSION Longer sleep duration was associated with lower blood pressure and adiposity measures in children. Improving sleep quality by increasing physical activity and light exposure in childhood may decrease the lifetime risk of cardiometabolic disease.
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Affiliation(s)
- Timothy Morgan
- Northwell, Cohen Children's Medical Center, Division of Pediatric Nephrology, New Hyde Park, New York, USA
| | - Abby Basalely
- Northwell, Cohen Children's Medical Center, Division of Pediatric Nephrology, New Hyde Park, New York, USA
| | - Pamela Singer
- Northwell, Cohen Children's Medical Center, Division of Pediatric Nephrology, New Hyde Park, New York, USA
| | - Laura Castellanos
- Northwell, Cohen Children's Medical Center, Division of Pediatric Nephrology, New Hyde Park, New York, USA
| | - Christine B Sethna
- Northwell, Cohen Children's Medical Center, Division of Pediatric Nephrology, New Hyde Park, New York, USA
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Han Y, Xia G, Harris L, Liu P, Guan D, Wu Q. Reversal of Obesity by Enhancing Slow-wave Sleep via a Prokineticin Receptor Neural Circuit. BIORXIV : THE PREPRINT SERVER FOR BIOLOGY 2024:2024.04.30.591948. [PMID: 38746393 PMCID: PMC11092673 DOI: 10.1101/2024.04.30.591948] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 05/16/2024]
Abstract
Obese subjects often exhibit hypersomnia accompanied by severe sleep fragmentation, while emerging evidence suggests that poor sleep quality promotes overeating and exacerbates diet-induced obesity (DIO). However, the neural circuit and signaling mechanism underlying the reciprocal control of appetite and sleep is yet not elucidated. Here, we report a neural circuit where prokineticin receptor 2 (PROKR2)-expressing neurons within the parabrachial nucleus (PBN) of the brainstem received direct projections from neuropeptide Y receptor Y2 (NPY2R)-expressing neurons within the lateral preoptic area (LPO) of the hypothalamus. The RNA-Seq results revealed Prokr2 in the PBN is the most regulated GPCR signaling gene that is responsible for comorbidity of obesity and sleep dysfunction. Furthermore, those NPY2R LPO neurons are minimally active during NREM sleep and maximally active during wakefulness and REM sleep. Activation of the NPY2R LPO →PBN circuit or the postsynaptic PROKR2 PBN neurons suppressed feeding of a high-fat diet and abrogated morbid sleep patterns in DIO mice. Further studies showed that genetic ablation of the PROKR2 signaling within PROKR2 PBN neurons alleviated the hyperphagia and weight gain, and restored sleep dysfunction in DIO mice. We further discovered pterostilbene, a plant-derived stilbenoid, is a powerful anti-obesity and sleep-improving agent, robustly suppressed hyperphagia and promoted reconstruction of a healthier sleep architecture, thereby leading to significant weight loss. Collectively, our results unveil a neural mechanism for the reciprocal control of appetite and sleep, through which pterostilbene, along with a class of similarly structured compounds, may be developed as effective therapeutics for tackling obesity and sleep disorders.
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Marhefkova N, Sládek M, Sumová A, Dubsky M. Circadian dysfunction and cardio-metabolic disorders in humans. Front Endocrinol (Lausanne) 2024; 15:1328139. [PMID: 38742195 PMCID: PMC11089151 DOI: 10.3389/fendo.2024.1328139] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/26/2023] [Accepted: 04/16/2024] [Indexed: 05/16/2024] Open
Abstract
The topic of human circadian rhythms is not only attracting the attention of clinical researchers from various fields but also sparking a growing public interest. The circadian system comprises the central clock, located in the suprachiasmatic nucleus of the hypothalamus, and the peripheral clocks in various tissues that are interconnected; together they coordinate many daily activities, including sleep and wakefulness, physical activity, food intake, glucose sensitivity and cardiovascular functions. Disruption of circadian regulation seems to be associated with metabolic disorders (particularly impaired glucose tolerance) and cardiovascular disease. Previous clinical trials revealed that disturbance of the circadian system, specifically due to shift work, is associated with an increased risk of type 2 diabetes mellitus. This review is intended to provide clinicians who wish to implement knowledge of circadian disruption in diagnosis and strategies to avoid cardio-metabolic disease with a general overview of this topic.
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Affiliation(s)
- Natalia Marhefkova
- Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czechia
- First Faculty of Medicine, Charles University, Prague, Czechia
| | - Martin Sládek
- Institute of Physiology, The Czech Academy of Sciences, Prague, Czechia
| | - Alena Sumová
- Institute of Physiology, The Czech Academy of Sciences, Prague, Czechia
| | - Michal Dubsky
- Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czechia
- First Faculty of Medicine, Charles University, Prague, Czechia
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Barber LE, McCullough LE, Johnson DA. Eyes Wide Open: Sleep as a Potential Contributor to Racial and Ethnic Disparities in Cancer. Cancer Epidemiol Biomarkers Prev 2024; 33:471-479. [PMID: 38270540 PMCID: PMC10990828 DOI: 10.1158/1055-9965.epi-23-1117] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/13/2023] [Revised: 11/05/2023] [Accepted: 01/22/2024] [Indexed: 01/26/2024] Open
Abstract
U.S. racial and ethnic minoritized groups face disproportionate cancer burdens compared to White Americans. Investigating modifiable factors, such as sleep, that are socially patterned and inequitably distributed by race and ethnicity may advance understanding of cancer disparities and provide intervention opportunities. Emerging data suggest poor sleep health is associated with cancer. Yet, its contribution to racial and ethnic cancer disparities is understudied. In this narrative review, we explored the sleep-cancer relation through a disparities lens. We (i) summarized literature reporting on associations between sleep and cancer among racial and ethnic minority populations; (ii) examined potential sleep-cancer mechanisms; and (iii) discussed future directions. We identified five studies reporting on sleep-cancer associations among minoritized groups. Poor sleep health was associated with aggressive breast cancer among Black women, increased breast cancer risk among Asian women, and increased risk of breast and total cancer among Hispanic/Latinx Americans. Sleep and cancer disparities have similar socioeconomic and behavioral determinants, suggesting racial and ethnic minoritized groups may be vulnerable to poor sleep health and its adverse health impacts. Evidence indicates that the sleep-cancer disparities relation is an emerging, but important area of research that warrants further investigation, as sleep may be an avenue for reducing cancer disparities.
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Affiliation(s)
- Lauren E. Barber
- Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA
| | - Lauren E. McCullough
- Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA
| | - Dayna A. Johnson
- Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA
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Chen Y, Zhang L, Yin H. Different emotion regulation strategies mediate the relations of corresponding connections within the default-mode network to sleep quality. Brain Imaging Behav 2024; 18:302-314. [PMID: 38057650 DOI: 10.1007/s11682-023-00828-9] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 11/19/2023] [Indexed: 12/08/2023]
Abstract
Despite a long history of interest in the relation of emotion regulation to sleep quality, how different strategies link with sleep quality at the neural level is still poorly understood. Thus, we utilized the process model of emotion regulation as an organizing framework for examining the neurological underpinning of the links between the two emotion regulation strategies and sleep quality. 183 young adults (51.7% females, Mage = 22.16) were guided to undergo the MRI scans and then complete the Pittsburgh Sleep Quality Index (PSQI) and the emotion regulation Questionnaire (ERQ) formed by two dimensions: cognitive reappraisal and expressive suppression. Results found that emotion regulation mediated the association between functional connectivity within the intrinsic default-mode network (DMN) and sleep quality. Specifically, rsFC analysis showed that cognitive reappraisal was positively correlated with rsFC within DMN, including left superior temporal gyrus (lSTG)-left lateral occipital cortex (lLOC), lSTG-left anterior cingulate gyrus (lACG), right lateral occipital cortex (rLOC)-left middle frontal gyrus (lMFG), and rLOC-lSTG. Further mediation analysis indicated a mediated role of cognitive reappraisal in the links between the four connectivity within the DMN and sleep quality. In addition, expressive suppression was positively correlated with rsFC within DMN, including left precuneus cortex (lPrcu)-right Temporal Pole (rTP) and lPrcu- lSTG. Further mediation analysis indicated a mediated role of expressive suppression in the links between the two connectivity within the DMN and sleep quality. Overall, this finding supports the process model of emotion regulation in that the effects of reappraisal and suppression have varying neural circuits that impact that strategy's effect on sleep quality.
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Affiliation(s)
- Yang Chen
- Department of Psychology, School of Education Science, Hunan Normal University, 36 Lushan Road, Changsha, Hunan, 410081, China
- Centre for Mind & Brain Science, Hunan Normal University, Changsha, China
| | - Li Zhang
- Department of Psychology, School of Education Science, Hunan Normal University, 36 Lushan Road, Changsha, Hunan, 410081, China
- Centre for Mind & Brain Science, Hunan Normal University, Changsha, China
| | - Huazhan Yin
- Department of Psychology, School of Education Science, Hunan Normal University, 36 Lushan Road, Changsha, Hunan, 410081, China.
- Centre for Mind & Brain Science, Hunan Normal University, Changsha, China.
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Lal H, Verma SK, Wang Y, Xie M, Young ME. Circadian Rhythms in Cardiovascular Metabolism. Circ Res 2024; 134:635-658. [PMID: 38484029 PMCID: PMC10947116 DOI: 10.1161/circresaha.123.323520] [Citation(s) in RCA: 4] [Impact Index Per Article: 4.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/03/2023] [Revised: 01/19/2024] [Accepted: 01/23/2024] [Indexed: 03/19/2024]
Abstract
Energetic demand and nutrient supply fluctuate as a function of time-of-day, in alignment with sleep-wake and fasting-feeding cycles. These daily rhythms are mirrored by 24-hour oscillations in numerous cardiovascular functional parameters, including blood pressure, heart rate, and myocardial contractility. It is, therefore, not surprising that metabolic processes also fluctuate over the course of the day, to ensure temporal needs for ATP, building blocks, and metabolism-based signaling molecules are met. What has become increasingly clear is that in addition to classic signal-response coupling (termed reactionary mechanisms), cardiovascular-relevant cells use autonomous circadian clocks to temporally orchestrate metabolic pathways in preparation for predicted stimuli/stresses (termed anticipatory mechanisms). Here, we review current knowledge regarding circadian regulation of metabolism, how metabolic rhythms are synchronized with cardiovascular function, and whether circadian misalignment/disruption of metabolic processes contribute toward the pathogenesis of cardiovascular disease.
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Affiliation(s)
- Hind Lal
- Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
| | - Suresh Kumar Verma
- Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
| | - Yajing Wang
- Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama, USA
| | - Min Xie
- Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
| | - Martin E. Young
- Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
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Neuwersch-Sommeregger S, Köstenberger M, Pipam W, Demschar S, Trummer B, Breschan C, Likar R. Pain in Austrian hospitals: evaluation of 1089 in-patients. Wien Med Wochenschr 2024; 174:69-78. [PMID: 36441358 DOI: 10.1007/s10354-022-00984-5] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/25/2022] [Accepted: 10/19/2022] [Indexed: 11/29/2022]
Abstract
BACKGROUND Despite the existence of internationally consistent guidelines for the management of pain, efficient regional anesthesia techniques, safe pain medications, and organizational structures, e.g., acute pain services, various studies have shown that pain is still common among both surgical and non-surgical in-patients. OBJECTIVE The primary objective of this study was to evaluate, on a multi-center basis, the point pain prevalence of surgical and non-surgical in-patients. We further analyzed pain intensities, in-hospital pain triggers, pain-related impairments, pain assessments, patient information about pain, and patient satisfaction with pain therapy. This benchmark information should lead to better implementation of pain management strategies and thus improve health care quality. METHODS We surveyed all adult in-patients in three general hospitals in Austria (general hospital Klagenfurt am Wörthersee, general hospital Villach, general hospital Wolfsberg) on the index day with two standardized questionnaires for both surgical and non-surgical patients. RESULTS Overall, a pain prevalence of 40.0%, with no statistically significant difference between surgical and non-surgical patients, was shown. Higher pain prevalence in female patients, high pain prevalence in the age group 18-30 years, and highest pain prevalence in the age group over 90 years old was found. Overall pain intensity was relatively low, but unacceptable maximum pain within the preceding 24 h was shown. Different in-hospital pain triggers like patient's care and mobilization were found. Our survey has shown that pain has an impact on personal hygiene, mobilization, mood, sleep, and appetite. However, patients were very satisfied with their pain therapy. CONCLUSION Medical staff and nurses have to be sensitized to the urgent need to improve pain management strategies.
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Affiliation(s)
- Stefan Neuwersch-Sommeregger
- Center for Interdisciplinary Pain Therapy, Oncology and Palliative Care, Clinic Center Klagenfurt, Klinikum Klagenfurt am Wörthersee, Feschnigstr. 11, 9020, Klagenfurt am Wörthersee, Austria.
- Medical University of Graz, Graz, Austria.
| | - Markus Köstenberger
- Center for Interdisciplinary Pain Therapy, Oncology and Palliative Care, Clinic Center Klagenfurt, Klinikum Klagenfurt am Wörthersee, Feschnigstr. 11, 9020, Klagenfurt am Wörthersee, Austria
- Medical University of Graz, Graz, Austria
| | - Wolfgang Pipam
- Center for Interdisciplinary Pain Therapy, Oncology and Palliative Care, Clinic Center Klagenfurt, Klinikum Klagenfurt am Wörthersee, Feschnigstr. 11, 9020, Klagenfurt am Wörthersee, Austria
| | - Susanne Demschar
- Center for Interdisciplinary Pain Therapy, Oncology and Palliative Care, Clinic Center Klagenfurt, Klinikum Klagenfurt am Wörthersee, Feschnigstr. 11, 9020, Klagenfurt am Wörthersee, Austria
| | - Brigitte Trummer
- Center for Interdisciplinary Pain Therapy, Oncology and Palliative Care, Clinic Center Klagenfurt, Klinikum Klagenfurt am Wörthersee, Feschnigstr. 11, 9020, Klagenfurt am Wörthersee, Austria
| | - Christian Breschan
- Center for Interdisciplinary Pain Therapy, Oncology and Palliative Care, Clinic Center Klagenfurt, Klinikum Klagenfurt am Wörthersee, Feschnigstr. 11, 9020, Klagenfurt am Wörthersee, Austria
- Medical University of Graz, Graz, Austria
| | - Rudolf Likar
- Center for Interdisciplinary Pain Therapy, Oncology and Palliative Care, Clinic Center Klagenfurt, Klinikum Klagenfurt am Wörthersee, Feschnigstr. 11, 9020, Klagenfurt am Wörthersee, Austria
- Paracelsus Medical University, Salzburg, Austria
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