Shibukawa N, Ouchi S, Wakamatsu S, Wakahara Y, Kaneko A. Gastric xanthoma is a predictive marker for metachronous and synchronous gastric cancer. World J Gastrointest Oncol 2017; 9(8): 327-332 [PMID: 28868113 DOI: 10.4251/wjgo.v9.i8.327]
Corresponding Author of This Article
Dr. Narihiro Shibukawa, Department of Gastroenterology, NTT West Osaka Hospital, 2-6-40 Karasugatsuji, Tennoji-ku, Osaka 543-8922, Japan. narihiro.shibukawa.pc@west.ntt.co.jp
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Aug 15, 2017; 9(8): 327-332 Published online Aug 15, 2017. doi: 10.4251/wjgo.v9.i8.327
Table 1 Clinicopathological characteristics of the two groups n (%)
Group A (n = 109)
Group B (n = 83)
P value
Age, median [IQR], yr
66 [61-74]
72 [63-78]
0.0009
Male
92 (84.4)
72 (86.7)
0.7
Diabetes mellitus
24 (22.0)
12 (14.5)
0.2
Complicated other malignant disease
27 (24.8)
22 (26.5)
0.9
Helicobacter pylori status
0.4
Positive
82
57
Post eradicated
23
26
Negative
4
0
Tumor location
0.9
Upper
10
11
Middle
57
39
Lower
42
33
Tumor size, median [IQR], mm
15 [10-20]
15 [12-22]
0.3
Macroscopic type
0.5
0-I
9
3
0-IIa
67
52
0-IIb
26
25
0-IIc
7
3
Differentiated type
109 (100)
81 (97.6)
0.2
Tumor depth
0.1
M
97
80
SM
12
3
Table 2 Endoscopic characteristics of the two groups n (%)
Group A (n = 109)
Group B (n = 83)
P value
Severe atrophy
87 (79.8)
74 (89.2)
0.1
Intestinal metaplasia
49 (45.0)
48 (57.8)
0.08
Gastric xanthoma
35 (32.1)
45 (54.2)
0.003
Table 3 Endoscopic score of risk for gastric cancer of the two groups
Group A (n = 109)
Group B (n = 83)
P value
Atrophy
0.005
0
4
0
1
6
0
2
99
83
Intestinal metaplasia
0.1
0
60
35
1
33
34
2
16
14
Fold swelling
0.6
0
99
73
1
10
10
Nodular gastritis
1.0
0
109
83
1
0
0
Diffuse redness
0.5
0
4
0
1
23
25
2
82
58
Total score, median [IQR]
4 [4-5]
4 [4-5]
0.1
Table 4 Multivariate analysis of predictive marker of metachronous and synchronous gastric cancer
Odds ratio
P value
Age
1.04 (1.01-1.08)
0.02
Male
1.38 (0.57-3.34)
0.47
Severe atrophy
1.68 (0.70-4.05)
0.25
Intestinal metaplasia
1.35 (0.71-2.54)
0.36
Gastric xanthoma
2.11 (1.14-3.99)
0.02
Citation: Shibukawa N, Ouchi S, Wakamatsu S, Wakahara Y, Kaneko A. Gastric xanthoma is a predictive marker for metachronous and synchronous gastric cancer. World J Gastrointest Oncol 2017; 9(8): 327-332