Soh JS, Lim H, Kang HS, Kim JH, Kim KC. Does the discrepancy in histologic differentiation between a forceps biopsy and an endoscopic specimen necessitate additional surgery in early gastric cancer? World J Gastrointest Oncol 2017; 9(8): 319-326 [PMID: 28868112 DOI: 10.4251/wjgo.v9.i8.319]
Corresponding Author of This Article
Kab Choong Kim, MD, PhD, Department of Surgery, University of Hallym College of Medicine, Hallym University Sacred Heart Hospital, 22 Gwanpyeong-ro 170-gil, Dongan-gu, Anyang 14068, South Korea. stonebody@hallym.or.kr
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
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Table 3 Histopathological characteristics of surgical specimens n (%)
Variables
Discrepancy
Non-discrepancy
P value
Tumor size in the specimen (n = 265)
Median, cm (range)
3.0 (0.8-5.5)
2.2 (0.4-8.5)
0.252
Tumor staging (n = 265)
Ia
7 (28.0)
121 (50.4)
0.033
Ib
18 (72.0)
119 (49.6)
Nodal staging (n = 265)
Positive
6 (24.0)
19 (7.9)
0.009
Negative
19 (76.0)
221 (92.1)
Lymphatic invasion (n = 265)
Positive
7 (28.0)
41 (17.1)
0.177
Negative
18 (72.0)
199 (82.9)
Vascular invasion (n = 265)
Positive
2 (8.0)
17 (7.1)
0.697
Negative
23 (92.0)
223 (92.9)
Ki-67 (n = 243)
High
20 (95.2)
186 (83.8)
0.215
Low
1 (4.8)
36 (16.2)
p53 (n = 243)
Positive
15 (71.4)
138 (62.2)
0.401
Negative
6 (28.6)
84 (37.8)
HER2 (n = 243)
Positive (2+ and 3+)
7 (33.3)
41 (18.5)
0.102
Negative (0 and 1+)
14 (66.7)
181 (81.5)
EGFR (n = 243)
Positive
17 (81.0)
123 (55.4)
0.035
Negative
4 (19.0)
99 (44.6)
Table 4 Comparison of histopathological characteristics between 23 specimens having discrepancy and 103 specimens having non-discrepancy along with undifferentiated postoperative histology n (%)
Variables
Discrepancy
Non-discrepancy
P value
Tumor size in the specimen (n = 126)
Median, cm (range)
3.0 (0.8-5.5)
2.5 (0.5-8.0)
0.343
Number of biopsies (n = 126)
Median, No. (range)
3 (2-6)
3 (1-8)
0.374
Location (n = 126)
Upper
3 (13.0)
10 (9.7)
0.481
Middle
10 (43.5)
62 (60.2)
Lower
10 (43.5)
31 (30.1)
Gross pattern (n = 126)
Elevated
1 (4.3)
1 (1.0)
0.615
Flat
4 (17.4)
20 (19.4)
Depressed
9 (39.1)
51 (49.5)
Mixed elevated
2 (8.7)
6 (5.8)
Mixed flat
4 (17.4)
16 (15.5)
Mixed depressed
3 (13.0)
9 (8.7)
Tumor staging (n = 126)
Ia
6 (26.1)
52 (50.5)
0.034
Ib
17 (73.9)
51 (49.5)
Nodal staging (n = 126)
Positive
6 (26.1)
9 (8.7)
0.020
Negative
17 (73.9)
94 (91.3)
Lymphatic invasion (n = 126)
Positive
7 (30.4)
12 (11.7)
0.023
Negative
16 (69.6)
91 (88.3)
Vascular invasion (n = 126)
Positive
2 (8.7)
2 (1.9)
0.152
Negative
21 (91.3)
101 (98.1)
Ki-67 (n=120)
High
48 (94.7)
77 (76.2)
0.119
Low
1 (5.3)
24 (23.8)
p53 (n = 120)
Positive
13 (68.4)
59 (58.4)
0.414
Negative
6 (31.6)
42 (41.6)
HER2 (n = 120)
Positive (2+ and 3+)
7 (36.8)
16 (15.8)
0.033
Negative (0 and 1+)
12 (63.2)
85 (84.2)
EGFR (n = 120)
Positive
16 (84.2)
52 (51.5)
0.011
Negative
3 (15.8)
49 (48.5)
Citation: Soh JS, Lim H, Kang HS, Kim JH, Kim KC. Does the discrepancy in histologic differentiation between a forceps biopsy and an endoscopic specimen necessitate additional surgery in early gastric cancer? World J Gastrointest Oncol 2017; 9(8): 319-326