Effects of age on survival and morbidity in gastric cancer patients undergoing gastrectomy

Table 1 Characteristics of patients in this study

	Group A	Group B	P value
Patients number	115	333
Sex (Male: female)	73/42	135/198
Mean age (yr)	83.44	65.87	< 0.05
Occupied lesion			0.693
U	24	81
M	39	114
L	52	138
Clinical stage (13th edition)			0.446
IA	40	137
IB	30	65
II	20	48
IIIA	9	39
IIIB	8	26
IV	8	18
Lymph nodes metastasis			0.639
Negative	76	212
Positive	39	121
Histological type			0.1224
Intestinal	70	175
Diffuse	45	158
Operative procedures			0.074
Distal gastrectomy	68	218
Total gastrectomy	34	95
Proximal gastrectomy	5	4
PPG	3	11
Partial gastrectomy	5	4
PD		1
Lymph nodes dissection			< 0.05
D0	18	8
D1	60	61
D2	36	264
Curability			< 0.05
Curative	97	310
Non-curative	18	23

PPG: Pylorus preserving gastrectomy; PD: Pancreaticoduodenectomy.

Table 2 Postoperative complications compared between two aged group

	Group A (n = 115)	Group B (n = 333)	P value
Anastomotic leakage	5 (4.3)	8 (2.4)	NS
Respiratory complications	7 (6.0)	7 (2.1)	< 0.05
Other complications
Pancreatitis	3 (2.6)	7 (2.1)	NS
Intraabdominal abscess	0 (0)	5 (1.5)	NS
Ileus	1 (0.87)	1 (0.3)	NS
Duodenal stump perforation	1 (0.87)	1 (0.3)	NS
Hepatic failure	1 (0.87)
Cholecystitis	0 (0)	1 (0.3)	NS
Hospital death	5 (4.3)	3 (0.9)	< 0.05

Table 3 Univariate analysis of overall survival in Group A patients after IPTW method

Variants	HR	95%CI	P value
Sex (male:female)	0.941	0.515-1.720	0.845
Tumor location (U:M:L)	0.967	0.779-1.202	0.768
Operative procedures (total:others)	1.005	0.813-1.242	0.961
Extent of LN dissection (D0:D1:D2)	0.661	0.4233-1.032	0.009
pStage (13th edition) (I:II:III:IV)	2.12	1.616-2.782	0.001
Radicality (curative:non-curative)	1.529	0.083-0.280	0.001
pLN metastasis (negative:positive)	2.332	1.274-4.272	0.006
Postoperative complications (negative:positive)	1.432	0.642-3.195	0.379
Histology (Lowren) (intestinal:diffuse)	2.637	1.470-4.729	0.01

Table 4 Multivariate analysis of overall survival in Group A

	Stepwise method (P < 0.1)
	HR	95%CI	P value
pStage	2.014	1.516-2.675	0.01
Histology (Lauren)	2.039	1.117-3.720	0.02
Extent of LN dissection	0.528	0.343-0.813	0.004