Nanomedicine strategies for sustained, controlled, and targeted treatment of cancer stem cells of the digestive system

Table 1 Nanomedicine-based therapies against cancer stem cells of the digestive system

Tumor types	Nanomedicine	Ref.
Drug delivery
Gastric cancer	SAL-loaded carbon nanotubes functionalized with HA	[82]
Liver cancer	SAL-loaded iRGD-conjugated DSPE-PEG2000 nanomicelles	[83]
Colorectal cancer	Curcumin-loaded CSO-SA micelles	[87]
	Oxaliplatin-loaded CSO-SA micelles	[88]
Gene delivery
Liver cancer	anti-EpCAM-monoclonal-antibody-labeled block copolymer vesicle	[89]
Colorectal cancer	Wtp53 gene loaded scL nanocomplex	[90]
Colon cancer	MDR1 siRNA loaded lipid nanoparticles	[91]
Gastric cancer	miR-200c loaded gelatinase-stimuli PEG-Pep-PCL nanoparticles	[94]
Targeted delivery
Gastric cancer	SAL-loaded carbon nanotubes functionalized with HA	[82]
Liver cancer	anti-CD44 antibody-mediated liposomal nanoparticle loaded of doxorubicin	[96]
	CD90-targeted thermosensitive magnetoliposomes-encapsulated 17-AAG	[97]
Combinational delivery
Gastric cancer	Nanoparticle co-loaded miR-200c and DOC	[99]
Liver cancer	micellar nanoparticle co-delivering platinum (IV) prodrug and siNotch1	[100]
Colorectal cancer	Liposomes co-encapsulated irinotecan and floxuridine	[101]
Colon cancer	Nanoliposomes co-encapsulated vincristine and topotecan	[102]