MicroRNA in pancreatic ductal adenocarcinoma and its precursor lesions

Table 1 MiRNA in pancreatic ductal adenocarcinoma

MiRNA	Whole pancreas	Serum and plasma	Saliva	Stool	Pancreatic juice
miR-10b		↑[54]
miR-16		↑[52]
miR-18a		↑[29,56,57]
miR-20a		↑[55,134]			↓[62]
miR-21	↑[22,24,27,32,34,38,55,71]	↑[55,71]		↑[63]↔[71]	↑[61,62,71]
miR-24		↑[55]
miR-27a-3p		↑[134]			↑[62]
miR-29c	↓[27]
miR-30a-3p	↓[27]
miR-30c		↓[37]
miR-31	↑[27]
miR-34a		↑[37]
miR-96	↓[27,135]				↓[62]
miR-99a		↑[52]
miR-101	↑[32]
miR-106b		↑[54]
miR-130b	↓[27]
miR-135b	↑[31]
miR-139-3p		↓[37,58]
miR-141	↓[27]
miR-143	↑[27,71]			↓[71]
miR-145	↑[27]
miR-146a	↑[27]				↑[62]
miR-148a	↓[27,29]
miR-148b	↓[27-29]
miR-150	↑[27]
miR-155	↑[22-24,27,32,66,71]	↑[22,54]		↑[63]↓[71]	↑[61,71]
miR-181a,b,d	↑[24]			↑[72]
miR-185		↑[52,55,134]
miR-191		↑[55]
miR-192		↑[37,58]
miR-194		↑[37]
miR-196a	↑[22,23,27,49,52,71]	↑[21,22,52,71]		↑[72]↓[71]	↑[62,71]
miR-196b	↑[27]				↑[60]
miR-200a		↑[136]			↑[62]
miR-200b		↑[136]
miR-205
miR-210	↑[27,71,137,138]	↑[137]		↑[72], ↔ [71]	↑[60,71]
miR-212	↑[38]	↑[37]
miR-216	↓[27,38]			↓[63]↓[71]
miR-217	↓[27]				↓[62]
miR-222	↑[24,27,38]
miR-223	↑[27]
miR-375	↓[27,71]			↔[71]
miR-492		↓[59]			↑[60]
miR-494	↓[27,74]
miR-508-5p		↓[37]
miR-513a-5p		↓[37]
miR-602		↑[37]
miR-630		↓[37]
miR-663a		↓[59]
miR-801		↑[37]
miR-887		↓[37]
miR-923		↓[37]
miR-940			↑[74]	↑[74]
miR-1290	↑[30]
miR-1427					↑[60]
miR-3679-5p			↓[74]	↓[72,74]

miR: MicroRNA; ↑: Up-regulated; ↓: Down-regulated; ↔: Unchanged.

Table 2 MiRNA in precursor lesions

MiRNA	IPMN	PanIN-1	PanIN-2	PanIN-3
miR-10b			↑[101]	↑[101]
miR-21	↑[23,32,87,88]	↑[100,101]	↑[98,99]	↑[98,99]
miR-92a	↑[93]
miR-99a	↓[91,93]
miR-99b	↓[91]
miR-100	↓[91,93]
miR-101	↓[32]
miR-125b	↑[93]
miR-126	↓ [91]
miR-130a	↓ [91]
miR-145	↑[93]
miR-148			↓[101]	↓[101]
miR-155	↑[23,32]	↑[101]	↑[98]	↑[98]
miR-182		↑[101]
miR-196a	↑[90]		↑[97]	↑[97]
miR-196b			↑[97]	↑[97]
miR-200a		↑[101]
miR-200b		↑[101]
miR-212	↓[93]
miR-217			↓[101]	↓[101]
miR-221	↑[87]
miR-296-5p		↑[101]
miR-342-3p	↓[91]
miR-483-3p	↑[88,93]

miR: MicroRNA; ↑: Up-regulated; ↓: Down-regulated; PanIN: Pancreatic intraepithelial lesions; IPMN: Intraductal papillary mucinous neoplasm.