Copyright
©The Author(s) 2016.
World J Gastrointest Oncol. Jan 15, 2016; 8(1): 121-127
Published online Jan 15, 2016. doi: 10.4251/wjgo.v8.i1.121
Published online Jan 15, 2016. doi: 10.4251/wjgo.v8.i1.121
Cancer | Sample | Sap No. | Method | Exp | Role | Ref. |
Colon | Stool | 60 | qPCR | ↑ | Diagnostic | [27] |
CRC | Tissue | 80 | qPCR | ↓ | Diagnostic/therapeutic | [21] |
CRC | Tissue | 8 | RT-PCR | ↓ | Therapeutic | [22] |
CRC | Tissue | 105 | qRT-PCR | ↑ | Prognostic | [26] |
ESCC | Tissue | 34 | Microarray/qRT-PCR | ↑ | Differentiation | [29] |
GC | Tissue | 40 | ISH/IHC | ↓ | Inhibits metastasis/EMT | [18] |
GC | Tissue | 23 | Microarray | ↓ | Inhibits invasion/metastasis | [19] |
qRT-PCR | ||||||
GC | Tissue | 28 | RT-PCR | ↓ | Represses inflammation | [20] |
HCC | Tissue | 10 | Microarray | - | Therapeutic/diagnostic/prognostic | [28] |
qRT-PCR | ||||||
HCC | Tissue | 12 | qRT-PCR | ↓ | Tumor suppressor | [23] |
HCC | Tissue | 429 | Chip assay | ↓ | Prognostic | [43] |
CD | Tissue | - | RT-PCR | ↓ | Therapeutic | [25] |
Cells | Function of miR-7 | Target | Ref. |
CCA | Reduces migration, invasion and metastasis | LAT1 | [41] |
CRC | Inhibits proliferation, invasion and metastasis, and induces G1 arrest | PAX6 | [21] |
CRC | Inhibits proliferation and induces apoptosis | XRCC2 | [22] |
CRC | Suppresses proliferation, induces G1 arrest, and induces apoptosis | YY1 | [37] |
GC | Suppresses invasion and metastasis | IGF1R | [18] |
GC | Inhibits proliferation, invasion and metastasis | EGFR | [19] |
HCC | Decreases invasion and migration | PIK3CD/mTOR/p70S6K | [28] |
HCC | Suppresses colony formation and induces cell cycle arrest | CUL5 | [23] |
- Citation: Chen WQ, Hu L, Chen GX, Deng HX. Role of microRNA-7 in digestive system malignancy. World J Gastrointest Oncol 2016; 8(1): 121-127
- URL: https://www.wjgnet.com/1948-5204/full/v8/i1/121.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v8.i1.121