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Copyright ©The Author(s) 2016.
World J Gastrointest Oncol. Jan 15, 2016; 8(1): 121-127
Published online Jan 15, 2016. doi: 10.4251/wjgo.v8.i1.121
Table 1 Expression of microRNA-7 in the digestive system
CancerSampleSap No.MethodExpRoleRef.
ColonStool60qPCRDiagnostic[27]
CRCTissue80qPCRDiagnostic/therapeutic[21]
CRCTissue8RT-PCRTherapeutic[22]
CRCTissue105qRT-PCRPrognostic[26]
ESCCTissue34Microarray/qRT-PCRDifferentiation[29]
GCTissue40ISH/IHCInhibits metastasis/EMT[18]
GCTissue23MicroarrayInhibits invasion/metastasis[19]
qRT-PCR
GCTissue28RT-PCRRepresses inflammation[20]
HCCTissue10Microarray-Therapeutic/diagnostic/prognostic[28]
qRT-PCR
HCCTissue12qRT-PCRTumor suppressor[23]
HCCTissue429Chip assayPrognostic[43]
CDTissue-RT-PCRTherapeutic[25]
Table 2 Function of microRNA-7 by targeting diverse genes
CellsFunction of miR-7TargetRef.
CCAReduces migration, invasion and metastasisLAT1[41]
CRCInhibits proliferation, invasion and metastasis, and induces G1 arrestPAX6[21]
CRCInhibits proliferation and induces apoptosisXRCC2[22]
CRCSuppresses proliferation, induces G1 arrest, and induces apoptosisYY1[37]
GCSuppresses invasion and metastasisIGF1R[18]
GCInhibits proliferation, invasion and metastasisEGFR[19]
HCCDecreases invasion and migrationPIK3CD/mTOR/p70S6K[28]
HCCSuppresses colony formation and induces cell cycle arrestCUL5[23]