Modulators affecting the immune dialogue between human immune and colon cancer cells

Table 1 Modulators acting on cross talk-induced cytokine secretion

	Ref.	Pro-inflammatory cytokines				Anti-inflammatory cytokines
		IL-1β	IL-6	TNFα	IFNγ	IL-1ra	IL-10
PBMC + colon cancer cells	Bessler et al[31] (2010)	↑↑	↑↑	↑↑	↑↑	↑↑	↑↑
Modulator
Aspirin	Bergman et al[45] (2011)	↑ slightly	↓	ND	↓/↑1	0/↓1	↓
Colchicine	(Submitted for publication)	↑	0/↑1	↓	ND	0	↓/↑1
Statins	Bergman et al[66] (2011)	↓	0	ND	↓	↓	↓
Caffeine	Bessler et al[75] (2012)	0	0	↓	↓	↓	↓
Resveratrol	Bergman et al[82] (2013)	↓	↑ /01	↓	↓	↓	↓
Curcumin	Bessler et al[92] (2012)	↓	↓	↓	ND	↓	↓
Vit. D3	Bessler et al[99] (2012)	↓	0	↓	ND	0	↓

¹Respresents results for HT-29-induced/RKO-induced cytokine secretion by PBMC. ND: Not determined; 0: No change in cytokine secretion; PBMC: Peripheral blood mononuclear cells; IFN: Interferon; TNFα: Tumor necrosis factor-α; IL-6: Interleukin-6; Vit. D3: Vitamin D3.