Multimodality management of resectable gastric cancer: A review

Table 1 Notable trial data for neoadjuvant and adjuvant therapies for gastric (or gastroesophageal) adenocarcinoma

Trial	No. of patients	Median survival (mo)	Overall survival	Progression-free survival
Neoadjuvant chemotherapy
EORTC 40954[20]			(2 yr)
5FU, cisplatin, folinic acid	72	64.62	72.70%	NR
Surgery alone	72	52.53	69.90%	NR
Perioperative chemotherapy
MAGIC Trial[26]			(5 yr)
ECF	250	NR	36.30%	NR
Surgery alone	253	NR	23%	NR
Fnlcc accord07/ffcd 9703[29]			(5 yr)	(5 yr)
5FU, cisplatin	113	NR	38%	34%
Surgery alone	111	NR	24%	19%
Adjuvant chemoradiation
INT-0116 trial[32]			(3 yr)	(3 yr)
5FU, CRT	281	36	50%	48%
Surgery alone	275	27	41%	31%
Artist trial[34]				(3 yr)
Capecitabine, cisplatin, CRT	230	NR	NR	78.20%
Capecitabine, cisplatin	228	NR	NR	74.20%
Adjuvant chemotherapy
ACTS-GC Trial[37]			(3, 5 yr)	(5 yr)
S-1	529	NR	80.1%, 71.7%	65.40%
Surgery alone	530	NR	70.1%, 61.1%	53.10%
Classic trial[40]			(3 yr)	(3 yr)
Capecitabine, oxaliplatin	520	NR	83%	74%
Surgery alone	515	NR	78%	59%

NR: Not reported; 5FU: 5-fluorouracil; ECF: Epirubicin/cisplatin/5-fluorouracil; CRT: Chemoradiation therapy.