Pathological aspects of so called "hilar cholangiocarcinoma"

Table 1 Observed survival of a series of 29 patients with resected hilar cholangiocarcinoma

Period (yr)	Observed survival (95%CI)
1	68.4 (51.3-85.5)
2	39.6 (21.5-57.7)
3	35.6 (17.7-53.5)
4	31.2 (13.5-48.9)
5	22.3 (6.2-38.4)

Table 2 Histological types of 29 cases of perihilar bile duct carcinomas n (%)

Histology
Adenocarcinoma, biliary type	24 (82.8)
Without IPNB	20 (69)
Well or moderately differentiated	18
Poorly differentiated with signet ring cells	2
With IPNB	4
Well or moderately differentiated	3
Poorly differentiated with signet ring cells	1
IPNB high grade (papillary carcinoma)	5 (17.2)
Without invasive carcinoma	1 (3.4)
With invasive carcinoma, biliary type	4 (13.8)
Well-moderately differentiated	3
Poorly differentiated with signet ring cells	1
Adenocarcinoma, gastric foveolar type	2 (13.8)
Adenocarcinoma, clear cell type	1 (3.4)
Adenosquamous carcinoma	1 (3.4)
Total number of cases	29

Table 3 Other histological features in 29 cases of perihilar bile duct carcinomas n (%)

Gross type
Sclerosing	10 (34.5)
Nodular	8 (27.6)
Nodular-sclerosing	6 (20.7)
Papillary	2 (6.9)
Papillary-nodular	2 (6.9)
Papillary-sclerosing	1 (3.4)
BilIN
BilIN-1 and/or 2	10 (34.5)
BilIN-1	9 (31)
BilIN-2	5 (17.2)
BilIN-3 (in situ carcinoma)	6 (20.7)
Lymphatic invasion (L1)	9 (31)
Venous invasion (V1)	11 (37.9)
Perineural invasion	23 (79.3)
T-staging (according to AJCC/UICC (7th ed)
pTis	1 (3.4)
pT1	1 (3.4)
pT2a	10 (34.5)
pT2b	12 (41.4)
pT3	5 (17.2)
Lymph node status:
Positive	7 (24.1)
Negative	16 (55.2)
No lymph nodes histologically studied	6 (20.7)
Margin status
Negative (R0)	12 (41.4)
Positive (R1) (invasive carcinoma)	17 (58.6)
Bile duct margin	10 (34.5)
Radial margin	11 (37.9)

BilIN: Biliary intraepithelial neoplasia; AJCC/UICC: American Joint Committee Cancer/Union for International Cancer Control.