Is there diversity among UGT1A1 polymorphism in Japan

doi:10.4251/wjgo.v4.i7.170

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Jul 15, 2012 (publication date) through Nov 24, 2024

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Jul 15, 2012; 4(7): 170-175
Published online Jul 15, 2012. doi: 10.4251/wjgo.v4.i7.170

Table 1 Examinee characteristics

	Akita	Kochi	Yamaguchi
Sex
Male	8	6	11
Female	42	44	39
Age (yr)	37.4 (23-55)	43.8 (24-66)	38.4 (18-67)

Table 2 Primers, probes used for genotyping

Gene	Variant	Primers and probes¹
UGT1A1*28	-53 TA6/TA7	F-FAM	5'-gtgacacagtcaaacattaacttgt-3'
		R	5'-gcctttgctcctgccagaggtt-3'
UGT1A7*3	N129K	F	5'-tacactctggaggatcagga-3'
	W208R	R	5'-tattgggcatcacgggtttg-3'
UGT1A9*22	-118 T10/T9	F	5'-acttaacattgcagcacagg-3'
		R	5'-atgggcaaaagccttgaact-3'
UGT1A1*93	-3156 G/A	F	5'-cagaagggctagagaggaggaa-3'
		R	5'-cttgctctcaaaactctgggataga-3'
		FAM	5'-cctgtccaagctca-3'
		VIC	5'-cacctgtctaagctca-3'
UGT1A1*6	211 G/A		C 559715 20
UGT1A1*27	686 C/A		C 2307598 20
UGT1A1*60	-3279 T/G		C 1432134 10
UGT1A7 (-57)	-57 T/G		C 287265 10

¹Primers for fragment size assay: F-FAM: Forward primer labeled FAM; R: Reverse primer. Primers for Sequence assay: F: Forward primer; R: Reverse primer. TaqMan assay: F: Forward primer; R: Reverse primer; FAM: Reporter 1 probe; VIC: Reporter 2 probe. Number: TaqMan SNP genotyping assays number.

Table 3 Polymorphisms of UGT1A1 n (%)

	UGT1A1*28 (P = 0.663)			UGT1A1*6 (P = 0.0496)			UGT1A1*27 (P = 1.000)			UGT1A1*60 (P = 0.766)			UGT1A1-3156
	6/6	6/7	7/7	A/A	G/A	G/G	A/A	C/A	C/C	G/G	T/G	T/T	A/A	G/A	G/G
A	41 (82)	8 (16)	1 (2)	1 (2)	20 (40)	29 (58)	0 (0)	0 (0)	50 (100)	2 (4)	19 (38)	29 (58)	1 (2)	8 (16)	41 (82)
K	37 (74)	13 (26)	0 (0)	0 (0)	14 (28)	36 (72)	0 (0)	1 (2)	49 (98)	1 (2)	25 (50)	24 (48)	0 (0)	13 (26)	37 (74)
Y	37 (74)	12 (24)	1 (2)	3 (6)	9 (18)	38 (76)	0 (0)	0 (0)	50 (100)	2 (4)	22 (44)	26 (52)	1 (2)	12 (24)	37 (74)

A: Akita prefecture; K: Kochi prefecture; Y: Yamaguchi prefecture.

Table 4 Polymorphisms of UGT1A7 and UGT1A9 n (%)

	UGT1A7 N129K (P = 0.853)			UGT1A7 W208R (P = 0.409)			UGT1A7 -57 (P = 0.409)			UGT1A9*22 (P = 0.993)
	G/G	T/G	T/T	C/C	T/C	T/T	G/G	T/G	T/T	9/9	9/10	10/10
A	7 (14)	24 (48)	19 (38)	2 (4)	23 (46)	25 (50)	2 (4)	23 (46)	25 (50)	5 (10)	24 (48)	21 (42)
K	8 (16)	20 (40)	22 (44)	4 (8)	17 (34)	29 (58)	4 (8)	17 (34)	29 (58)	6 (12)	22 (44)	22 (44)
Y	5 (10)	23 (46)	22 (44)	4 (8)	14 (28)	32 (64)	4 (8)	14 (28)	32 (64)	5 (10)	23 (46)	22 (44)

A: Akita prefecture; K: Kochi prefecture; Y: Yamaguchi prefecture.

Citation: Kobayashi M, Hazama S, Takahashi K, Oba K, Okayama N, Nishioka M, Hinoda Y, Oka M, Okamoto K, Maeda H, Nakamura D, Sakamoto J, Mishima H. Is there diversity among UGT1A1 polymorphism in Japan. World J Gastrointest Oncol 2012; 4(7): 170-175
URL: https://www.wjgnet.com/1948-5204/full/v4/i7/170.htm
DOI: https://dx.doi.org/10.4251/wjgo.v4.i7.170