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©2012 Baishideng Publishing Group Co.
World J Gastrointest Oncol. Jan 15, 2012; 4(1): 1-8
Published online Jan 15, 2012. doi: 10.4251/wjgo.v4.i1.1
Published online Jan 15, 2012. doi: 10.4251/wjgo.v4.i1.1
Study | Majority population | Sample | Method | Allelic markers | Informative cases/controls | ASE (binary) cases/controls | ASE higher in CRC cases | |
Binary | Continuous | |||||||
Valle et al[73] 2008 | Caucasian | Blood | SNaPshot | rs334348 | 138/105 | 221.0%/2.9% | Yes | Yes |
rs7871490 | ||||||||
rs334349 | ||||||||
rs1590 | ||||||||
Guda et al[74] 2009 | Caucasian | Lymph. cell line | Pyroseq | rs868 | Familial: 46/17 | 34.3%/0% | No | |
Normal colon | rs334348 | Sporadic: 44/0 | 30%/- | |||||
rs334349 | ||||||||
rs420549 | ||||||||
rs1590 | ||||||||
Carvajal-Carmona et al[66] 2010 | Caucasian | Lymph. cell line | Genescan | *6A/9A | Familial: 24/45 | 329.2%/26.7% | No | No |
SNaPshot | rs1590 | |||||||
Pasche et al[75] 2010 | Caucasian | Lymph. cell line | SNaPshot | rs334348 | 74/0 | 314.9%/- | Yes | |
rs7871490 | ||||||||
rs334349 | ||||||||
rs1590 | ||||||||
Tomsic et al[76] 2010 | Caucasian | Blood | Pyroseq | rs868 | 1109/125 | 31.8%/1.6% | No | Yes |
rs334348 | 246.8%/31.2% | |||||||
rs334349 | ||||||||
rs420549 | ||||||||
rs1590 | ||||||||
Seguí et al[77] 2011 | Caucasian | Normal colon | Pyroseq | rs334349 | 171/90 | 30%/2.2% | No | No |
Ashkenazi | Lymphocytes | rs7850895 | 22.3%/2.2% | |||||
rs420549 | ||||||||
rs1590 | ||||||||
Abadie et al[78] 2011 | Caucasian | Blood | SNaPshot | rs334348 | 69/98 | 30%/0% | No | No |
rs7871490 | ||||||||
rs334349 | ||||||||
rs1590 |
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Citation: Valle L. Debate about
TGFBR1 and the susceptibility to colorectal cancer. World J Gastrointest Oncol 2012; 4(1): 1-8 - URL: https://www.wjgnet.com/1948-5204/full/v4/i1/1.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v4.i1.1