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World J Gastrointest Oncol. Apr 15, 2010; 2(4): 187-191
Published online Apr 15, 2010. doi: 10.4251/wjgo.v2.i4.187
Published online Apr 15, 2010. doi: 10.4251/wjgo.v2.i4.187
Study | Year | Types ofGastrointestinal Surgery | n(Trad/Early) | Earlyfeeding protocol | Outcomes |
Lucha et al[4] | 2005 | Open colorectal surgery | 25/26 | Regular diet from 8 hr following surgery | No difference in post operative complications between groups (1 d vs 1 d) or LOS 6.6 d vs 6.3 d |
Zhou et al[5] | 2006 | Excision and anastomosis for colorectal tumour | 155/161 | Liquid fibreless diet D1-3 post op | Statistically significant benefits of early feeding Flatus 3.0 ± 0.9 d vs 3.6 ± 1.2 d, P = 0.000 Stool 4.1 ± 1.1 d vs 4.8 ± 1.4 d, P = 0.000 LOS 8.4 ± 3.4 d vs 9.6 ± 5.0 d, P = 0.016 Reduced complications with early feeding Reduced febrile illness: 3 vs 15, P = 0.042 Pulmonary infection: 1 vs 7, P = 0.034 Pharyngolaryngitis: 5 vs 36, P = 0.000 No differences in wound complications 4 vs 3, P = 1.0 No differences in anastomotic leakage 2 vs 4, P = 0.441 |
Han-Geurts et al[6] | 2007 | Open colorectal surgery | 50/46 | Regular diet from D1 post op | No statistically significant differences in outcomes between groups in any in-hospital complication, including mortality. No statistically significant differences between return of bowel function and length of hospital stay between groups |
Lassen et al[7] | 2008 | Hepatic, pancreatic, oesophageal, gastric resections, bilioenteric and gastroenteric bypass procedures, unspecified procedures in which traditional NBM management would be indicated | 227/220 | Early oral feeding provided with ordinary hospital diet from D1 post op NB control group received enteral nutrition via a jejunostomy tube from D1 post op | No differences between number of patients major complications between groups (33% in jejunum fed vs 28% early oral, P = 0.26); less overall complications in early oral feeding group (100 vs 165, P = 0.012) No differences in mortality between groups within the trial period (8.4% early jejunum feeding vs 5.9% early oral, P = 0.36) Increased likelihood of intra-abdominal abscesses in gastrectomy patients with early jejunum feeding vs early oral intake (6 vs 0, P = 0.012) Shorter duration to passage of flatus early oral feeding group (2.6 vs 3.0 d, P = 0.01); no difference for duration to first bowel motion (4.3 vs 4.0 d, P = 0.112) Longer length of stay with jejunum fed patients (16.7 vs 13.5 d, P = 0.046) |
Lewis, Egger, Sylvester & ThomasBMJ 2001[8] | Andersen, Lewis & ThomasCochrane Database Syst Rev 2006[9] | Lewis, Andersen & ThomasJ Gastrointest Surg 2009[10] | |
Inclusion criteria | Elective gastrointestinal surgery RCTs Enteral feeding within 24 h post op vs NBM/traditional management Included unpublished data | RCTs (un/published) Colorectal surgery Early feeding (within 24 h) vs NBM Malignant/benign disease incl. IBD Studies solely in paediatric population RCTs with no blinding If reported on outcomes including adverse outcomes, mortality | RCTs (unpublished/published) Colorectal surgery Early feeding (within 24 h) vs NBM Malignant/benign disease including inflammatory bowel diseases Studies solely in paediatric population RCTs with no blinding If reported on outcomes including adverse outcomes, mortality |
Exclusion criteria | Not stated | PN Non-RCTs Unpublished abstracts with no correspondence data | PN Non-RCTs Unpublished abstracts with no correspondence data |
Number of patients | 929 | 1173 | 1173 |
Number of included studies | 11 | 13 | 13 |
Publication dates | 1979-1998 | 1979-2004 | 1979-2004 |
Gastrointestinal surgery types included | Colonic, ileal or colonic resection; oesophago-gastrectomy, gastrectomy, ileoanal J pouch, reanastomosis; esophagectomy, pancreatoduodenectomy; unspecified laparotomy | Colonic, ileal or colonic resection; oesophago-gastrectomy, gastrectomy, ileoanal J pouch, reanastomosis; esophagectomy, pancreatoduodenectomy; unspecified laparotomy | Colonic, ileal or colonic resection; oesophago-gastrectomy, gastrectomy, ileoanal J pouch, reanastomosis; esophagectomy, pancreatoduodenectomy; unspecified laparotomy |
Outcomes | |||
Wound infections | RR 0.71 (0.44-1.17) χ2 value not reported, P = 0.074 | RR 0.77 (0.48-1.22) P = 0.3 (FEM) χ2 = 10.30 P = 0.26 | RR 0.78 (0.38, 1.68) (REM) RR 0.77 ( 0.48-1.22) P = 0.3 (FEM) χ2 = 10.30 P = 0.26 |
Intra-abdominal abscesses | RR 0.87 (0.31-2.42) χ2 value not reported, P = 0.84 | RR 0.87 (0.31–2.42) P = 0.8 χ2 = 1.45 P = 0.84 | RR 0.94 (0.32, 2.77) (REM) RR 0.87 (0.31–2.42) P = 0.8 (FEM) χ2 = 1.45 P = 0.84 |
Pneumonia | RR 0.73 (0.33–1.59) χ2 value not reported, P = 0.85 | RR 0.76 (0.36-1.58) P = 0.5 χ2 = 3.73 P = 0.81 | RR 0.71 (0.32, 1.59) (REM) RR 0.76 (0.36-1.58) P = 0.5 (FEM) χ2 = 3.73 P = 0.81 |
Any infection | RR 0.72 (0.54-0.98) P = 0.036 χ2 = 10.7, P = 0.22 | Not assessed | Not assessed |
Mortality | RR 0.48 (0.18-1.29) P = 0.15 χ2 value not reported, P = 0.99 | RR 0.41 (0.18-0.93) P = 0.03 χ2 = 0.6 P = 0.99 | RR 0.42 (0.18, 0.96) (REM) RR 0.41 (0.18-0.93) P = 0.03 (FEM) χ2 = 0.6 P = 0.99 |
Anastomotic dehiscence | RR 0.53 (0.26-1.08) P = 0.08 χ2 = 2.1, P = 0.96 NB-little evidence that data from proximal vs distal feeding results differed P = 0.42 | RR 0.69 (0.39-1.32) P = 0.3 χ2 = 4.89 P = 0.77 | RR 0.62 (0.30, 1.28) (REM) RR 0.69 (0.39-1.32) P = 0.3 (FEM) χ2 = 4.89, P =0.77 for FEM. No χ2 reported for REM |
Length of hospital stay | -0.84 d (-0.36-1.33) P = 0.001 χ2 = 16.2, P = 0.094 | -0.60 d (-0.66, -0.54) χ2 = 18.86 P = 0.06 | -0.89 d (-1.58, -0.20) (REM) -0.60 d (-0.66, -0.54) (FEM) χ2 = 18.86 P = 0.06 |
Vomiting | RR 1.27 (1.01-1.61) P = 0.045 χ2 value not reported, P = 0.52 NB-non-significant increase in N&V with early feeding where NGs were not placed at time of surgery RR 1.21 (0.73-1.99) P = 0.46 | RR 1.27, (1.01-1.61) P = 0.04 χ2 = 4.21 P = 0.52 | RR 1.23 (0.97, 1.55) (REM) RR 1.27 (1.01-1.61) (FEM) χ2 = 4.21 P = 0.52 |
- Citation: Osland EJ, Memon MA. Early postoperative feeding in resectional gastrointestinal surgical cancer patients. World J Gastrointest Oncol 2010; 2(4): 187-191
- URL: https://www.wjgnet.com/1948-5204/full/v2/i4/187.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v2.i4.187