Differential colorectal carcinogenesis: Molecular basis and clinical relevance

Table 1 Genes with microsatellite instability in their coding sequences. Adapted from reference [75]

Gene	Function	Coding repeat
ACTRII	Growth/differentiation factor receptor	(A) 8
AIM2	IFN inducible	(A) 10
AXIN-2	Wnt signaling	(A) 6*2, (G) 7, (C) 6
BAX	Proapoptotic factor	(G) 8
BCL-10	Proapoptotic factor	(A) 8
BLM	Response to DNA damage	(A) 9
Caspase-5	Proapoptotic factor	(A) 10
CDX2	Homeobox transcription factor	(G) 7
CHEK1	Response to DNA damage	(A) 9
FAS	Proapoptotic factor	(T) 7
GRB-14	Growth factor bound protein	(A) 9
hG4-1	Cell cycle	(A) 8
IGFIIR	Growth factor receptor	(G) 8
KIAAO977	Homologue to mouse cordon bleu	(T) 9
MBD-4	DNA glycosylase and methyl CpG binding protein	(A) 10
MLH3	MMR	(A) 9
MSH3	MMR	(A) 8
MSH6	MMR	(C) 8
NADH-UOB	NADH ubiquinone oxidoreductase	(T) 9
OGT	O-linked GlcNAc transferase	(T) 10
PTEN	Cell cycle	(A) 6*2
RAD-50	Response to DNA damage	(A) 9
RHAMM	Cell motility	(A) 9
RIZ	Cell cycle and apoptotic protein	(A) 8, (A) 9
SEC63	ER membrane protein	(A) 10, (A) 9
SLC23AI	Nucleobase transporter	(C) 9
TCF-4	Transcription factor (Wnt pathway)	(A) 9
TGFβRII	Growth factor receptor	(A) 10
WISP-3	Growth factor (Wnt pathway)	(A) 9