Long-term complete response in stage IVa esophageal squamous cell carcinoma treated with chemoradiotherapy and modulated electro-hyperthermia: A case report

Table 1 Treatment timeline and interventions

Day (date)	Intervention and clinical status
Day 0 (July 29, 2020)	Diagnosis and initial care: Diagnosis of stage IVa (cT4N3M0) esophageal squamous cell carcinoma complicated by pneumonia, cachexia (body mass index 14.0), and anemia. Initiation of intravenous antibiotics; blood transfusions to correct anemia
Day 5 (August 3, 2020)	Supportive care: Placement of gastrostomy tube and port-A; initiation of nutritional support
Day 14 (August 12, 2020)	Treatment initiation: Commencement of definitive concurrent chemoradiotherapy using volumetric modulated arc therapy and PF4 regimen (cisplatin/5-FU)
Day 14-58 (August 12-September 25, 2020)	Adjunctive therapy: Eight sessions of modulated electro-hyperthermia administered twice weekly using the Oncotherm EHY-2000+ system; mean thermal energy 290.9 kJ (range: 282.1-324.9 kJ)
Day 58 (September 25, 2020)	Completion of treatment: Successful completion of the full course of chemoradiotherapy and modulated electro-hyperthermia without interruptions
Day 126 (December 2, 2020)	Initial response evaluation: Endoscopy revealed a healing ulcer without malignancy (biopsy-proven). Patient’s weight increased from 40 kg to 52 kg (body mass index: 18.2)
Day 1968 (December 18, 2025)	Long-term follow-up (> 5 years): Latest follow-up via computed tomography scan and endoscopy confirmed ongoing disease-free status (complete response) with no late complications