Copyright: ©Author(s) 2026.
World J Gastrointest Oncol. Aug 15, 2026; 18(8): 116559
Published online Aug 15, 2026. doi: 10.4251/wjgo.116559
Published online Aug 15, 2026. doi: 10.4251/wjgo.116559
Table 1 Comparison of outcomes between total neoadjuvant therapy-RAPIDO and standard long-course chemoradiotherapy, median
| Outcome | Total neoadjuvant therapy-RAPIDO | Standard long-course chemoradiotherapy | P value |
| R0 resection rate | 93.1% | 90.0% | 0.65 |
| Lymph node harvest | 40.7 | 23.4 | < 0.001 |
| Total stoma duration (weeks) | 27.1 | 42.5 | 0.02 |
| Permanent stoma rate | 13.8% | 35.7% | 0.01 |
| Pathological complete response rate | 13.8% | 10.0% | 0.58 |
| 30-day morbidity rate | 17.2% | 21.4% | 0.63 |
| Operative time (minutes) | 185 | 178 | 0.51 |
- Citation: Zhou SQ, Ke QH. Letter to the Editor: Total neoadjuvant therapy for locally advanced rectal cancer: Navigating beyond surgical outcomes to holistic patient-centered care. World J Gastrointest Oncol 2026; 18(8): 116559
- URL: https://www.wjgnet.com/1948-5204/full/v18/i8/116559.htm
- DOI: https://dx.doi.org/10.4251/wjgo.116559