Gamma delta T-cell infusion plus chemotherapy induces long-term remission of gastric cancer after immunochemotherapy failure: A case report

Table 1 Timeline of the clinical course

Time	Key events and treatments	Response/outcome
At diagnosis	Diagnosis of gastric adenocarcinoma; palliative subtotal gastrectomy with Roux-en-Y gastrojejunostomy; peritoneal metastasis found intraoperatively	Stage IV disease confirmed
0-6 months after surgery	Capecitabine/oxaliplatin plus nivolumab (first-line)	Progressive disease with new liver metastasis and lymphadenopathy
After progression	Ramucirumab plus paclitaxel (second-line, 2 cycles)	Stopped due to peripheral neuropathy
Next 4 months	Ramucirumab plus trifluridine/tipiracil combined with autologous γδ T-cell infusions (7 cycles)	Radiologic complete response on computed tomography
After the response	Liver wedge resection of the treated lesion	No viable tumor cells (pathologic response)
Additional 3 months	Continuation of ramucirumab, trifluridine/tipiracil, and γδ T-cell infusion	No evidence of disease progression
Follow-up (≥ 24 months after completion)	Routine surveillance	No recurrence

γδ: Gamma delta.