Lipid levels and insulin resistance markers in patients with colorectal cancer: Propensity score matching analysis

Table 1 Basic information of patients with colorectal cancer before and after propensity score matching

Characteristics	All CRC, n = 277	Propensity-matched CRC, n = 207
Ascending colon	55 (11.4)	42 (8.7)
Transverse colon	11 (2.3)	8 (1.7)
Descending colon	18 (3.7)	14 (2.9)
Sigmoid colon	68 (14)	49 (10.1)
Rectum	125 (25.8)	94 (19.4)
T. stage
T1	28 (5.8)	23 (4.8)
T2	36 (7.4)	25 (5.2)
T3	196 (40.5)	148 (30.6)
T4	17 (3.5)	11 (2.3)
N. stage
N0	156 (32.2)	119 (24.6)
N1	71 (14.7)	53 (11)
N2	50 (10.3)	35 (7.2)
M. stage
M0	251 (51.9)	190 (39.3)
M1	26 (5.4)	17 (3.5)
Blood vessels
-	199 (41.1)	150 (31)
+	78 (16.1)	57 (11.8)
Nerve
-	210 (43.4)	159 (32.9)
+	67 (13.8)	48 (9.9)
Size, median (IQR)	4 (3, 5)	4 (3, 5)
Differentiation
Low grade	94 (19.4)	69 (14.3)
High grade	183 (37.8)	138 (28.5)
Stage
I	55 (11.4)	41 (8.2)
II	95 (19.6)	72 (14.9)
III	100 (20.7)	73 (15.1)
IV	27 (5.6)	19 (3.9)

Data are n (%) unless otherwise indicated. CRC: Colorectal cancer; IQR: Interquartile range.

Table 2 Characteristics of study participants

Characteristics	All patients			Propensity-matched patients
	Control, n = 1034	CRC, n = 277	P value	Controls, n = 207	CRC, n = 207	P value
Age in years	66.53 ± 7.41	66.54 ± 10.91	0.989	68.89 ± 5.53	65.58 ± 11.12	0.053
Sex as male/female	466/568	176/101	< 0.001	96/111	122/85	0.010
Hypertension in %	10.25	43.68	< 0.001	34.78	28.99	0.206
Diabetes in %	1.64	14.80	< 0.001	7.73	5.80	0.434
Coronary heart disease or Cerebral infarction in %	0.48%	12.64	< 0.001	2.24	2.24	1
BMI	25.09 ± 5.25	23.78 ± 3.27	< 0.001	24.40 ± 3.77	23.84 ± 3.29	0.106
WBC as × 109/L	6.49 ± 1.58	6.16 ± 1.84	0.003	6.64 ± 1.66	6.14 ± 1.84	0.004
RBC as × 109/L	4.70 ± 0.43	4.19 ± 0.61	< 0.001	4.66 ± 0.40	4.21 ± 0.58	< 0.001
Hb in g/L	143.23 ± 13.24	120.63 ± 25.73	< 0.001	141.89 ± 12.61	121.47 ± 25.08	< 0.001
PLT as × 109/L	216.94 ± 52.78	240.59 ± 83.72	< 0.001	224.17 ± 51.69	240.94 ± 78.97	0.011
ALT in U/L	21.36 ± 7.75	18.50 ± 31.60	0.144	20.33 ± 7.63	17.65 ± 18.27	0.057
AST in U/L	21.40 ± 12.65	21.24 ± 35.77	0.908	19.36 ± 12.60	19.73 ± 11.93	0.758
TC in mmol/L	4.81 ± 0.98	4.23 ± 0.97	< 0.001	4.80 ± 1.02	4.34 ± 0.94	< 0.001
TG in mmol/L	1.65 ± 1.21	1.35 ± 0.73	< 0.001	1.84 ± 1.87	1.33 ± 0.65	< 0.001
HDL-C in mmol/L	1.38 ± 0.36	1.14 ± 0.32	< 0.001	1.41 ± 0.41	1.17 ± 0.32	< 0.001
LDL-C in mmol/L	3.10 ± 0.87	2.66 ± 0.85	< 0.001	3.01 ± 0.86	2.76 ± 0.83	0.003
UA in mmol/L	319.84 ± 77.29	315.62 ± 81.37	0.430	324.75 ± 80.97	312.42 ± 78.70	0.121
SCR in mmoI/L	74.63 ± 22.89	76.67 ± 21.08	0.190	78.29 ± 26.10	73.84 ± 19.89	0.056
CEA in ng/mL	1.91 ± 1.51	35.67 ± 176.15	0.002	2.80 ± 1.54	26.62 ± 95.89	0.001
CA199 in U/mL	11.26 ± 7.64	176.16 ± 1013.41	0.009	12.00 ± 8.77	159.62 ± 929.85	0.027
AI	2.65 ± 1.05	35.67 ± 176.15	0.002	2.64 ± 1.35	2.89 ± 1.14	0.042
TyG index	8.81 ± 0.58	8.58 ± 0.55	< 0.001	8.86 ± 0.59	8.55 ± 0.51	< 0.001

AI: Atherosclerotic index; ALT: Alanine aminotransferase; AST: Aspartate transaminase; BMI: Body mass index; CEA: Carcinoembryonic antigen; CRC: Colorectal cancer; Hb: Hemoglobin; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; PLT: Platelet; RBCs: Red blood cells; SCR: Serum creatinine; TC: Total cholesterol; TG: Triglyceride; TyG: Triglyceride-glucose; UA: Uric acid; WBCs: White blood cells.

Table 3 Various combined diagnostic indicators for patients with colorectal cancer

Indicator	AUC	95%CI	Cut-off value	P value
TC	0.6243	0.5709-0.6777	4.325	< 0.0001
TG	0.6406	0.5873-0.6938	1.345	< 0.0001
HDL-C	0.6802	0.6292-0.7311	1.165	< 0.0001
LDL-C	0.5812	0.5263-0.6360	3.035	0.0043
CEA	0.6429	0.5882-0.6976	5.15	< 0.0001
CA19-9	0.5623	0.5057-0.6190	23.225	0.0305
AI	0.5748	0.5199-0.6298	2.655	0.0085
TyG index	0.6572	0.6048-0.7097	8.635	< 0.0001
CEA + CA199 + TYG index	0.7525	0.7052-0.7997		< 0.0001

AI: Atherosclerotic index; AUC: Area under the curve; CEA: Carcinoembryonic antigen; CI: Confidence interval; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; SCR: Serum creatinine; TG: Triglyceride; TC: Total cholesterol; TyG: Triglyceride-glucose.