Development and validation of a nomogram for predicting lymph node metastasis in early gastric cancer

Table 1 Demographic and clinicopathological data for both cohorts

Factor	Development group		Validation group
	LNM-, n = 602	LNM+, n = 148	LNM-, n = 197	LNM+, n = 53
Age in yr
≤ 60	340	88	103	38
> 60	262	60	94	15
Sex
Female	210	68	72	31
Male	392	80	125	22
BMI
≤ 24	421	100	130	36
> 24	181	48	67	17
Tumor size in cm
≤ 2	392	47	107	17
> 2	210	101	90	36
Tumor location
Proximal	66	2	17	1
Middle	96	39	31	20
Distal	440	107	149	32
Differentiation
Poor	450	136	78	40
Moderate	119	10	77	10
Well	33	2	42	3
Pathological type
AC	403	67	147	23
SRCC	199	81	50	30
CEA
Normal	566	136	179	50
Abnormal	36	12	18	3
CA125
Normal	589	143	194	52
Abnormal	13	5	3	1
CA19-9
Normal	578	140	190	52
Abnormal	24	8	7	1
CA242
Normal	589	146	191	52
Abnormal	13	2	6	1
CA72-4
Normal	549	131	177	45
Abnormal	53	17	20	8

AC: Adenocarcinoma; BMI: Body mass index; CA125: Carbohydrate antigen 125; CEA: Carcinoembryonic antigen; LNM: Lymph node metastasis; SRCC: Signet ring cell carcinoma.

Table 2 Univariate and multivariate analysis of lymph node metastasis factors in patients with early gastric cancer

Variables	Univariate		Multivariate
	χ2	P value	OR	95%CI	P value
Age in yr	0.431	0.512	NA	NA	NA
Sex	6.232	0.013	0.787	0.525-1.179	0.245
BMI	0.314	0.576	NA	NA	NA
Tumor size in cm	54.467	< 0.001	4.430	2.964-6.620	0.000
Tumor location	19.260	< 0.001	NA	NA	NA
Middle	NA	NA	7.568	1.692-33.857	0.008
Distal	NA	NA	4.479	1.040-19.281	0.044
Differentiation	20.501	< 0.001	NA	NA	NA
Poor	NA	NA	NA	NA	0.015
Moderate	NA	NA	0.400	0.192-0.834	0.015
Well	NA	NA	0.260	0.059-1.154	0.076
Pathological type	23.851	< 0.001	1.716	1.130-2.606	0.011
CEA	0.898	0.343	NA	NA	NA
CA125	0.753	0.385	NA	NA	NA
CA19-9	0.585	0.444	NA	NA	NA
CA242	0.396	0.529	NA	NA	NA
CA72-4	1.010	0.315	NA	NA	NA

BMI: Body mass index; CA125: Carbohydrate antigen 125; CEA: Carcinoembryonic antigen; CI: Confidence interval; NA: Not applicable; OR: Odds ratio; SRCC: Signet ring cell carcinoma.

Table 3 Univariate analysis and multivariate analysis affecting the prognosis of patients with early gastric cancer

Variable	Univariate	Multivariate
	P value	HR	95%CI	P value
Tumor size	0.023	1.288	0.92-1.861	0.177
Tumor location	0.206
Differentiation	0.022	1.310	0.897-1.913	0.163
Pathological type	0.000	2.357	1.558-3.565	0.000
LNM	0.000	1.817	1.170-2.820	0.008

CI: Confidence interval; HR: Hazard ratio; LNM: Lymph node metastasis.