METTL5 promotes cell proliferation, invasion, and migration by up-regulating Toll-like receptor 8 expression in colorectal cancer

Table 1 Associations of METTL5 expression with clinical parameters in colorectal cancer

Variable		METTL5 expression		P value
		Low (n = 75)	High (n = 75)
Gender	Female	31	40	0.141
	Male	44	35
Age (yr)	> 55	48	51	0.605
	≤ 55	27	24
Tumor size (cm)	> 3.5	55	56	0.852
	≤ 3.5	20	19
Vascular invasion	Positive	35	37	0.744
	Negative	40	38
Nerve invasion	Positive	31	36	0.412
	Negative	44	39
Differentiation degree	High/median	25	45	0.001
	Low	50	30
Depth of infiltration	T1/T2	50	49	0.863
	T3/T4	25	26
Positive lymph nodes	≥ 3	10	16	0.196
	< 3	65	59
TNM stage	I/II	57	26	< 0.001
	III/IV	18	49

TNM: Tumor-node-metastasis.

Table 2 Univariate and multivariate analyses of survival in patients with colorectal cancer (Cox proportional hazards regression model)

Variable	Univariate analysis			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
Age (yr)
> 55 vs ≤ 55	1.217	0.827-1.789	0.319
Gender
Female vs male	0.845	0.589-1.211	0.36
Tumor site
Colon vs rectum	0.698	0.463-1.053	0.087
Tumor size
> 3.5 cm vs ≤ 3.5 cm	1.09	0.717-1.657	0.687
Differentiation degree
Poor vs high/median	1.483	1.034-2.128	0.032a	1.485	1.029-2.143	0.035a
Vascular invasion
Positive vs negative	1.011	0.705-1.45	0.951
Nerve invasion
Positive vs negative	1.139	0.793-1.635	0.482
TNM stage
I/II vs III/IV	1.659	1.157-2.38	0.006a	1.498	1.024-2.193	0.037a
METTL5 expression
Decreased vs non-decreased	1.831	1.272-2.635	0.001a	1.582	1.078-2.323	0.019a

^aP < 0.05.

HR: Hazard ratio; CI: Confidence interval; TNM: Tumor-node-metastasis.