Pathologically successful conversion hepatectomy for advanced giant hepatocellular carcinoma after multidisciplinary therapy: A case report and review of literature

Table 1 Local laboratory data before the initiation of therapy in a 69-year-old man with advanced hepatocellular carcinoma with invasion of the right branch of the portal vein

Variables	Value	Unit
AFP	657	ng/mL
WBC	3.18	109/L
Hemoglobin	104	g/L
Platelet	95	109/L
ALT	36.7	U/L
AST	102.8	U/L
ALP	212	U/L
γ-GTP	111.1	U/L
Albumin	25.7	g/L
T-BIL	15.3	umol/L
D-BIL	7.6	umol/L
PT	13.6	s
APTT	31.2	s
TT	19.1	s
Fibrinogen	2.16	s

γ-GTP: γ-glutamyl transpeptidase; AFP: Alpha-fetoprotein; ALP: Alkaline phosphatase; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; D-BIL: Direct bilirubin; T-BIL: Total-bilirubin; PT: Prothrombin time; APTT: Activated partial thromboplastin time; TT: Thrombin time; WBC: White blood cell.

Table 2 Child-Pugh scores

Variables	1	2	3
Hepatic encephalopathy (stage)	None	1-2	3-4
Ascites	None	mild	Moderate-severe
T-BIL (umol/L)	< 34	34-51	< 51
Albumin (g/L)	< 35	28-35	< 28
Prothrombin time (s)	< 14	14-18	< 18

Child-Pugh stage A: 5-6; Child-Pugh stage B: 7-9; Child-Pugh stage C: ≥ 10.

Table 3 Summary of published case reports of conversion therapy in advanced hepatocellular carcinoma patients

Ref.	Age	Sex	Underlying liver disease	Tumor size	Symptom	Previous treatment	Pathological response rate
Wei et al[22]	67	Male	Hepatitis B	7.2 cm × 7.1 cm × 6.4 cm	Abdominal discomfort	HAIC, TACE, Immunotargeted therapy	PR
Ning et al[23]	48	Male	Hepatitis B	16.2 cm × 11.2 cm	Palpable mass	TACE, Immunotargeted therapy	PR
Ning et al[23]	54	Male	Hepatitis B	14.9 cm × 11.8 cm	Abdominal pain	TACE, Immunotargeted therapy	CR
Zhou et al[24]	69	Male	Hepatitis B	12.7 cm × 10.3 cm	None	HAIC, TAE, Immunotargeted therapy	PR
Wu et al[25]	41	Male	Hepatitis B	7.1 cm × 5.5 cm × 5.1 cm	Abdominal pain	Immunotargeted therapy	CR
Chen et al[26]	49	Male	Hepatitis B	7.1 cm × 5.5 cm	None	Immunotargeted therapy	PR
Chen et al[27]	52	Male	Hepatitis B	11.3 cm × 12.0 cm × 11.9 cm	Abdominal pain	TACE, Targeted therapy	CR
Chen et al[27]	42	Male	Hepatitis B	11.4 cm × 8.9 cm × 10.0 cm	None	HAIC, TACE, Targeted therapy	PR
Yano et al[28]	68	Male	None	7.2 cm in S1	None	Immunotargeted therapy	PR
Zhang et al[29]	67	Male	None	The largest was ≥ 10 cm	Epigastric distention	TACE, antiviral therapy	PR
Tomonari et al[30]	69	Male	Alcoholic cirrhosis	7.3 cm	Abdominal pain	TAE, targeted therapy	PR
Tomonari et al[30]	71	Female	Nonalcoholic steatohepatitis	5.8 cm in S3	None	TAE, targeted therapy	PR
Tomonari et al[30]	73	Male	Alcoholic cirrhosis	5.2 cm in S5	None	TAE, targeted therapy	PR

HAIC: Hepatic arterial infusion chemotherapy; TAE: Transcatheter arterial embolization; TACE: Transcatheter arterial chemoembolization; PR: Partial remission; CR: Complete remission.