Zhang YJ, Yuan MX, Wen W, Li F, Jian Y, Zhang CM, Yang Y, Chen FL. Mucosa color and size may indicate malignant transformation of chicken skin mucosa-positive colorectal neoplastic polyps. World J Gastrointest Oncol 2024; 16(3): 750-760 [PMID: 38577441 DOI: 10.4251/wjgo.v16.i3.750]
Corresponding Author of This Article
Meng-Xia Yuan, MD, Doctor, Department of Digestive Diseases, Chengdu Second People’s Hospital, No. 10 Qingyun South Street, Chengdu 610000, Sichuan Province, China. 1062274198@qq.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Cohort Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Mar 15, 2024; 16(3): 750-760 Published online Mar 15, 2024. doi: 10.4251/wjgo.v16.i3.750
Table 1 Comparison of baseline clinical and endoscopic characteristics of chicken skin mucosa-positive colorectal polyps
Juvenile polyps (n = 5)
Neoplastic polyps (n = 70)
NHGN (n = 86)
SM stage cancer (n = 22)
P value
Age (mean SD, yr) (n = 177)
26.66 8.17
58.68 9.15
61.26 11.12
64.4 8.73
< 0.001
diameter (cm) (n = 183)
1.57 0.34
0.88 0.37
1.61 0.52
1.93 0.53
< 0.001
Sex (n = 177)
Male
4
33
46
15
0.34
Female
1
31
40
7
Location (n = 183)
Left colon
2
48
50
12
0.38
Rectum
3
22
36
10
Morphology (n = 183)
Polypoid (Is, Isp, Ip)
5
57
75
18
0.63
Nonpolypoid (IIa, LST)
0
13
11
4
CSM
Type 1
5
25
59
17
< 0.001
Type 2
0
45
27
5
Table 2 Comparison of the endoscopic features of risk factors for malignant transformation of chicken skin mucosa-positive neoplastic polyps on white light endoscopy
Endoscopic features
Neoplastic polyps (n = 70)
NHGN (n = 86)
P value
Multilobulated
20
40
0.03
Round and smooth
54
21
0.00
Deeper red mucosal color
11
54
0.00
Granulated surface
2
6
0.55
Table 3 Comparison of endoscopic features of invasion depth of chicken skin mucosa-positive early colorectal cancer with white light endoscopy
Endoscopic features
NHGN (n = 86)
SM stage cancer (n = 22)
P value
Ulceration or errhysis (all)
2
3
0.08
Demarcated depressed area (all)
3
14
< 0.001
Deeper red mucosal color (all)
54
16
0.25
Stalk swelling (P)
7
3
0.65
Fullness (P)
12
4
0.81
Table 4 Logistic regression analyses of endoscopic risk features for malignant transformation of chicken skin mucosa-positive neoplastic polyps
Variable
OR (95%CI)
P value
Diameter (≥ 10/< 10 mm)
15.84 (5.01–50)
0.00
CSM (type ½)
0.56 (0.23–1.36)
0.20
Multilobulated
0.4 (0.13–1.22)
0.11
Deeper red mucosal color
3.5 (1.25–9.82)
0.02
Table 5 Logistic regression analyses of endoscopic risk features for early submucosal invasion of chicken skin mucosa-positive colorectal cancer
Variable
OR (95%CI)
P value
CSM (type ½)
1.63 (0.37–7.14)
0.52
Ulcer bleeding
1.68 (0.08–37.06)
0.74
Demarcated depressed area
78.03 (13.04–466.94)
0.00
Diameter (≥ 10/< 10 mm)
1.28 (0.14–11.67)
0.83
Table 6 Type of chicken skin mucosa endoscopic resection in different subgroups
Juvenile polyps (n = 5)
Neoplastic polyps (n = 70)
NHGN (n = 81)
SM stage cancer (n = 7)
P value
Complete resection
0
30
26
2
0.194
Partial resection
5
40
55
5
Citation: Zhang YJ, Yuan MX, Wen W, Li F, Jian Y, Zhang CM, Yang Y, Chen FL. Mucosa color and size may indicate malignant transformation of chicken skin mucosa-positive colorectal neoplastic polyps. World J Gastrointest Oncol 2024; 16(3): 750-760