Effect of screening colonoscopy frequency on colorectal cancer mortality in patients with a family history of colorectal cancer

Table 1 Comparison of clinical and pathological data between the two groups

	Laparoscopic colectomy group (n = 63)	Open colectomy group (n = 41)	P value
Age (yr)	72.3 ± 5.0	70.8 ± 4.3	0.109
Sex (n)		0.532	0.466
Male	37	27
Female	26	14
Tumor size (cm)	4.7 ± 2.3	4.4 ± 1.4	0.406
Tumor location (n)			0.281
Colon	36	19
Rectum	27	22
Right colon	20	8
Left colon	4	1
Transverse colon cancer	0	3
Total colon	1	0
Sigmoid colon	11	7
Low rectum	18	6
High rectum	6	9
Middle rectum	3	7
Degree of tumor differentiation (n)		1.279	0.528
Well differentiation	20	13
Moderate differentiation	36	26
Low differentiation	7	2
T stage (n)		0.811	0.667
T1	0	0
T2	4	2
T3	52	32
T4	7	7
Lymph node metastasis (n)		0.633	0.426
N0	35	26
N1	28	15
N2	0	0
TNM stage (n)		3.195	0.362
IIA	32	20
IIB	3	6
IIIA	4	2
IIIB	24	13

TNM: Tumor-node-metastasis.

Table 2 Comparison of oncological indicators between the two groups

	Laparoscopic colectomy group, (n = 63)	Open colectomy group, (n = 41)	t-value	P value
Length of specimen (cm)
Colon cancer	30.1 ± 17.8	23.6 ± 9.3	1.492	0.142
Rectal cancer	19.7 ± 8.6	16.8 ± 4.2	1.364	0.394
Tumor distance from proximal margin (cm)
Colon cancer	12.1 ± 6.4	12.8 ± 6.4	0.885	0.721
Rectal cancer	9.2 ± 4.3	8.9 ± 3.9	0.281	0.770
Tumor distance from distal margin (cm)
Colon cancer	10.1 ± 8.8	7.9 ± 4.0	0.984	0.330
Rectal cancer	6.5 ± 4.5	4.3 ± 1.7	0.148	0.883
Number of resected lymph nodes (n)
Colon cancer	11.1 ± 6.3	12.0 ± 6.0	0.602	0.380
Rectal cancer	9.0 ± 5.3	10.3 ± 5.7	0.148	0.349
Number of positive lymph nodes (n)
Colon cancer	0.7 ± 1.1	0.5 ± 0.7	0.853	0.398
Rectal cancer	1.1 ± 1.7	0.6 ± 1.1	1.446	0.258

Table 3 Comparison of intestinal cleaning compliance rate between the two groups, n (%)

Group	N	1	2	3	4	Rate
Laparoscopic colectomy group (n = 63)	63	23	20	10	4	57 (90.47)
Open colectomy group (n = 41)	41	10	10	1	1	22 (53.66)
χ2	-	-	-	-	-	6.939
P value	-	-	-	-	-	0.008

Table 4 Comparison of perioperative-related indicators between the two groups

	Laparoscopic colectomy group, (n = 63)	Open colectomy group, (n = 41)	χ2, t, or Z value	P value
Preoperative comorbidities, n (%)
Anemia	25 (39.7)	7 (17.1)	5.960	0.015a
Intestinal obstruction	12 (19)	5 (12.2)	0.853	0.356
Hypoproteinemia	17 (27)	7 (17.1)	1.374	0.241
High blood pressure	20 (31.7)	12 (29.3)	0.072	0.789
Diabetes	7 (11.1)	4 (9.8)	0.048	0.826
Pneumonia or bronchitis	8 (12.7)	8 (19.5)	0.886	0.347
Viral hepatitis	6 (9.5)	1 (2.4)	1.986	0.159
History of digestive disease, n (%)	5 (7.9)	5 (12.2)	0.518	0.472
Average operation time (min)	175.2 ± 43.8	171.9 ± 58.8	0.325	0.746
Intraoperative bleeding (mL)	80.4 ± 60.6	169.4 ± 95.1	5.325	0.000a
Postoperative hospital stay (d)	12.9 ± 3.7	13.7 ± 6.7	0.837	0.405
Time to first ambulation (d)	2.8 ± 2.1	5.1 ± 2.2	5.243	0.000a
Time to first liquid meal (d)	3.7 ± 1.9	5.0 ± 2.1	3.142	0.002a
Time to first exhaust (d)	3.3 ± 1.3	3.9 ± 1.5	1.960	0.053
Postoperative complications, n (%)	6 (9.5)	9 (22.0)	3.108	0.078
Bleeding from the anastomosis	1	2
Anastomotic fistula	1	0
Postoperative intestinal obstruction	1	3
Infection of the incision	0	1
Abdominal infection	0	1
Diarrhea	3	1
Postoperative urinary retention	0	1

^aP < 0.05 represents a significant difference between the two groups.

Table 5 Comparison of results of bowel preparation assessment in 104 patients undergoing colonoscopy

Group	BBPS score	Colonoscopy time (min)	Adenoma detection rate (%)
Laparoscopic colectomy group (n = 63)	7.24 ± 1.07	5.63 ± 1.93	26.00
Open colectomy group (n = 41)	5.63 ± 1.93	9.81 ± 2.08	13.33
t/χ2	49.21	5.79	4.75
P value	< 0.0001	0.02	0.03

BBPS: Boston bowel preparation scale