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©The Author(s) 2024.
World J Gastrointest Oncol. Dec 15, 2024; 16(12): 4636-4649
Published online Dec 15, 2024. doi: 10.4251/wjgo.v16.i12.4636
Published online Dec 15, 2024. doi: 10.4251/wjgo.v16.i12.4636
Variables | Number of patients |
Age | |
≥ 75 and < 80 | 70 (50.4) |
≥ 80 | 69 (49.6) |
Sex | |
Female | 39 (28.1) |
Male | 100 (72.9) |
Marital status | |
Married | 133 (95.7) |
Unmarried | 6 (4.3) |
Smoke | |
No | 84 (60.4) |
Yes | 55 (39.6) |
Drink | |
No | 102 (73.4) |
Yes | 37 (26.6) |
C stage | |
I-II | 24 (17.3) |
III-IVa | 93 (66.9) |
IVb | 22 (15.8) |
T stage | |
T1-T2 | 22 (15.8) |
T3-T4 | 117 (84.2) |
N stage | |
Negative | 22 (15.8) |
Positive | 117 (84.2) |
M stage | |
M0 | 117 (84.2) |
M1 | 22 (15.8) |
Tumor length | |
< 6 | 90 (64.7) |
≥ 6 | 49 (35.3) |
Tumor location | |
Upper thoracic | 34 (24.5) |
Middle thoracic | 62 (44.6) |
Lower thoracic | 43 (30.9) |
ECOG | |
0-1 | 133 (95.7) |
2 | 6 (4.3) |
CCI | |
0 | 62 (44.6) |
≥ 1 | 77 (55.4) |
NRS2002 | |
< 3 | 66 (47.5) |
≥ 3 | 73 (52.5) |
BMI | |
< 18.5 | 32 (23.0) |
≥ 18.5 | 107 (77.0) |
Weight loss | |
< 10% | 128 (92.1) |
≥ 10% | 11 (7.9) |
Radiation dose | |
< 60 | 57 (41.0) |
≥ 60 | 82 (59.0) |
Chemotherapy | |
No | 36 (25.9) |
Yes | 103 (74.1) |
Variables | Univariate analysis | Multivariate analysis | ||||||
HR | Lower 95%CI | Upper 95%CI | P value | HR | Lower 95%CI | Upper 95%CI | P value | |
Age | ||||||||
≥ 75 and < 80 | 1 | |||||||
≥ 80 | 1.147 | 0.769 | 1.710 | 0.502 | ||||
Sex | ||||||||
Female | 1 | |||||||
Male | 0.656 | 0.427 | 1.009 | 0.055 | ||||
Marital status | ||||||||
Married | 1 | |||||||
Unmarried | 0.538 | 0.132 | 2.188 | 0.387 | ||||
Smoke | ||||||||
No | 1 | |||||||
Yes | 0.821 | 0.544 | 1.239 | 0.348 | ||||
Drink | ||||||||
No | 1 | |||||||
Yes | 0.869 | 0.545 | 1.387 | 0.557 | ||||
C stage | ||||||||
I-II | 1 | 1 | ||||||
III-IVa | 2.261 | 1.189 | 4.298 | 0.013 | 2.421 | 1.242 | 4.718 | 0.009 |
IVb | 3.444 | 1.593 | 7.446 | 0.002 | 4.222 | 1.888 | 9.438 | < 0.001 |
T stage | ||||||||
T1-T2 | 1 | |||||||
T3-T4 | 1.575 | 0.876 | 2.831 | 0.129 | ||||
N stage | ||||||||
Negative | 1 | |||||||
Positive | 2.030 | 1.104 | 3.732 | 0.023 | ||||
M stage | ||||||||
M0 | 1 | |||||||
M1 | 1.761 | 1.038 | 2.986 | 0.036 | ||||
Tumor length | ||||||||
< 6 | 1 | |||||||
≥ 6 | 1.261 | 0.836 | 1.904 | 0.269 | ||||
Tumor location | ||||||||
Upper thoracic | 1 | |||||||
Middle thoracic | 1.054 | 0.632 | 1.759 | 0.840 | ||||
Lower thoracic | 1.146 | 0.665 | 1.976 | 0.623 | ||||
ECOG | ||||||||
0-1 | 1 | |||||||
2 | 2.023 | 0.820 | 4.995 | 0.126 | ||||
CCI | ||||||||
0 | 1 | 1 | ||||||
≥ 1 | 1.620 | 1.080 | 2.429 | 0.020 | 1.539 | 1.015 | 2.332 | 0.042 |
NRS2002 | ||||||||
< 3 | 1 | 1 | ||||||
≥ 3 | 2.215 | 1.466 | 3.348 | < 0.001 | 2.491 | 1.601 | 3.875 | < 0.001 |
BMI | ||||||||
< 18.5 | 1 | |||||||
≥ 18.5 | 0.756 | 0.482 | 1.183 | 0.221 | ||||
Weight loss | ||||||||
< 10% | 1 | 1 | ||||||
≥ 10% | 2.947 | 1.473 | 5.898 | 0.002 | 1.798 | 0.870 | 3.715 | 0.113 |
Radiation dose | ||||||||
< 60 | 1 | |||||||
≥ 60 | 0.771 | 0.511 | 1.164 | 0.217 | ||||
Chemotherapy | ||||||||
No | 1 | |||||||
Yes | 0.847 | 0.543 | 1.320 | 0.463 |
Toxicity | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
Leukocytopenia | 31 (22.3) | 43 (30.9) | 6 (4.3) | 1 (0.7) |
Anemia | 29 (20.8) | 21 (15.1) | 8 (5.7) | 1 (0.7) |
Thrombopenia | 3 (2.1) | 2 (1.4) | 2 (1.4) | 1 (0.7) |
Esophagitis | 19 (13.6) | 40 (28.7) | 7 (5.5) | 0 (0.0) |
Pneumonitis | 1 (0.7) | 2 (1.4) | 2 (1.4) | 0 (0.0) |
Dermatitis | 2 (1.4) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
- Citation: Hu LL, Rong F, Liu L, Zhang L, Zhang LL, Yang Q, Xia ZL, Wang H. Prognosis of radiotherapy for esophageal cancer in elderly patients exceeding seventy-five years old. World J Gastrointest Oncol 2024; 16(12): 4636-4649
- URL: https://www.wjgnet.com/1948-5204/full/v16/i12/4636.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v16.i12.4636