Retrospective Study
Copyright ©The Author(s) 2024.
World J Gastrointest Oncol. Dec 15, 2024; 16(12): 4636-4649
Published online Dec 15, 2024. doi: 10.4251/wjgo.v16.i12.4636
Table 1 Demographics and clinical characteristics of patients, n (%)
Variables
Number of patients
Age
≥ 75 and < 8070 (50.4)
≥ 8069 (49.6)
Sex
Female39 (28.1)
Male100 (72.9)
Marital status
Married133 (95.7)
Unmarried6 (4.3)
Smoke
No84 (60.4)
Yes55 (39.6)
Drink
No102 (73.4)
Yes37 (26.6)
C stage
I-II24 (17.3)
III-IVa93 (66.9)
IVb22 (15.8)
T stage
T1-T222 (15.8)
T3-T4117 (84.2)
N stage
Negative22 (15.8)
Positive117 (84.2)
M stage
M0117 (84.2)
M122 (15.8)
Tumor length
< 690 (64.7)
≥ 649 (35.3)
Tumor location
Upper thoracic34 (24.5)
Middle thoracic62 (44.6)
Lower thoracic43 (30.9)
ECOG
0-1133 (95.7)
26 (4.3)
CCI
062 (44.6)
≥ 177 (55.4)
NRS2002
< 366 (47.5)
≥ 373 (52.5)
BMI
< 18.532 (23.0)
≥ 18.5107 (77.0)
Weight loss
< 10%128 (92.1)
≥ 10%11 (7.9)
Radiation dose
< 6057 (41.0)
≥ 6082 (59.0)
Chemotherapy
No36 (25.9)
Yes103 (74.1)
Table 2 Univariate and multivariate Cox analysis of the determinants of overall survival of patients
Variables
Univariate analysis
Multivariate analysis
HR
Lower 95%CI
Upper 95%CI
P value
HR
Lower 95%CI
Upper 95%CI
P value
Age
≥ 75 and < 801
≥ 801.1470.7691.7100.502
Sex
Female1
Male0.6560.4271.0090.055
Marital status
Married1
Unmarried0.5380.1322.1880.387
Smoke
No1
Yes0.8210.5441.2390.348
Drink
No1
Yes0.8690.5451.3870.557
C stage
I-II11
III-IVa2.2611.1894.2980.0132.4211.2424.7180.009
IVb3.4441.5937.4460.0024.2221.8889.438< 0.001
T stage
T1-T21
T3-T41.5750.8762.8310.129
N stage
Negative1
Positive2.0301.1043.7320.023
M stage
M01
M11.7611.0382.9860.036
Tumor length
< 61
≥ 61.2610.8361.9040.269
Tumor location
Upper thoracic1
Middle thoracic1.0540.6321.7590.840
Lower thoracic1.1460.6651.9760.623
ECOG
0-11
22.0230.8204.9950.126
CCI
011
≥ 11.6201.0802.4290.0201.5391.0152.3320.042
NRS2002
< 311
≥ 32.2151.4663.348< 0.0012.4911.6013.875< 0.001
BMI
< 18.51
≥ 18.50.7560.4821.1830.221
Weight loss
< 10%11
≥ 10%2.9471.4735.8980.0021.7980.8703.7150.113
Radiation dose
< 601
≥ 600.7710.5111.1640.217
Chemotherapy
No1
Yes0.8470.5431.3200.463
Table 3 Treatment-related acute toxicities in patients, n (%)
Toxicity
Grade 1
Grade 2
Grade 3
Grade 4
Leukocytopenia31 (22.3)43 (30.9)6 (4.3)1 (0.7)
Anemia29 (20.8)21 (15.1)8 (5.7)1 (0.7)
Thrombopenia3 (2.1)2 (1.4)2 (1.4)1 (0.7)
Esophagitis19 (13.6)40 (28.7)7 (5.5)0 (0.0)
Pneumonitis1 (0.7)2 (1.4)2 (1.4)0 (0.0)
Dermatitis2 (1.4)0 (0.0)0 (0.0)0 (0.0)