Uninvolved liver dose prediction in stereotactic body radiation therapy for liver cancer based on the neural network method

Table 1 Correlation coefficients between D_n0-D_n100 and D_nmean of the uninvolved liver and the V_nsub-organ

Dose	Vnsub-organ1	Vnsub-organ2	Vnsub-organ3	Vnsub-organ4	Vnsub-organ5	P value
Dn0	0.529b	0.414b	0.332b	0.276b	0.238a	P < 0.01
Dn10	0.689b	0.694b	0.674b	0.662b	0.654b	P < 0.01
Dn20	0.653b	0.704b	0.702b	0.706b	0.710b	P < 0.01
Dn30	0.587b	0.667b	0.686b	0.706b	0.721b	P < 0.01
Dn40	0.542b	0.630b	0.664b	0.693b	0.718b	P < 0.01
Dn50	0.533b	0.608b	0.641b	0.670b	0.695b	P < 0.01
Dn60	0.563b	0.628b	0.654b	0.676b	0.697b	P < 0.01
Dn70	0.605b	0.642b	0.653b	0.664b	0.676b	P < 0.01
Dn80	0.653b	0.670b	0.669b	0.668b	0.672b	P < 0.01
Dn90	0.664b	0.669b	0.663b	0.652b	0.649b	P < 0.01
Dn100	0.539b	0.466b	0.417b	0.378b	0.354b	P < 0.01
Dnmean	0.675b	0.725b	0.732b	0.742b	0.752b	P < 0.01

^aP < 0.05. This suggests that the observed correlation is statistically significant at the 5% level, meaning there is less than a 5% chance of observing such results if the null hypothesis were true.

^bP < 0.01, indicating a higher level of statistical significance. This implies that the observed correlation is statistically significant at the 1% level, with less than a 1% chance of occurring under the null hypothesis.

Pearson’s correlation test was used to analyze the correlation. The P value provides a quantitative measure of the statistical significance of the observed results.

Table 2 R-value of the neural network prediction model

Dose	Training	Verification	Test	All
Dn0	0.8792	0.6458	0.6207	0.7513
Dn10	0.9209	0.8115	0.8126	0.8813
Dn20	0.9101	0.8509	0.8720	0.8918
Dn30	0.9261	0.8510	0.9561	0.9139
Dn40	0.9674	0.8915	0.8697	0.9274
Dn50	0.8319	0.8146	0.8629	0.8263
Dn60	0.9252	0.8278	0.8537	0.8858
Dn70	0.9162	0.8332	0.8924	0.9010
Dn80	0.8397	0.7873	0.7825	0.8199
Dn90	0.8599	0.8138	0.8079	0.8391
Dn100	0.9715	0.7300	0.8336	0.8606
Dnmean	0.9088	0.9498	0.7943	0.9006

Table 3 Mean square error of the neural network prediction model

Dose	MSE
Dn0	0.0071
Dn10	0.0066
Dn20	0.0080
Dn30	0.0075
Dn40	0.0035
Dn50	0.0046
Dn60	0.0022
Dn70	0.0012
Dn80	0.0006
Dn90	0.0004
Dn100	0.0006
Dnmean	0.0019

MSE: Mean square error.