LINC01268 promotes epithelial-mesenchymal transition, invasion and metastasis of gastric cancer via the PI3K/Akt signaling pathway and targeting MARCKS

Table 1 Association between the expression level of LINC01268 and clinicopathological factors of human gastric cancer

Characteristics	No. of each group	LINC01268 expression		P value
		High	Low
All cases	62	39	23
Age (yr)
≥ 60	38	23	15	0.626
< 60	24	16	8
Gender
Male	53	32	21	0.531
Female	9	7	2
Smoking
Yes	23	15	8	0.772
No	39	24	15
Drinking alcohol
Yes	21	14	7	0.661
No	41	25	16
Maximum tumor diameter
≥ 5	25	19	6	0.079
< 5	37	20	17
Depth of invasion
pT1-pT2	8	5	3	1.000
pT3-pT4	54	34	20
Lymph node metastasis
pN0	10	2	8	0.007
pN1-pN3	52	37	15
Distant metastasis
pM0	59	36	23	0.453
pM1	3	3	0
Tumor TNM stage
I-II	12	4	8	0.043
III-IV	50	35	15
Histology
Middle differentiated and well differentiated	23	10	13	0.015
Poor differentiated	39	29	10
Macroscopic types
Mass	3	0	3	0.378
Ulcerative	12	8	4
Infiltrative ulcerative	47	31	16
Diffuse infiltrative	0	0	0
Venous/lymphatic invasion
Positive	10	7	3	0.881
Negative	52	32	20
Nervous invasion
Positive	7	5	2	0.936
Negative	55	34	21
Fatty nodules
Positive	8	7	1	0.250
Negative	54	32	22
Liver metastasis
Present	3	2	1	1.000
Absent	59	37	22
Ascitic fluid
Negative	48	30	18	0.903
Positive	14	9	5

Table 2 Univariate and multivariate analyses of invasion and metastasis factors in gastric cancer patients

Factors	Univariate analysis		Multivariate analysis
	OR (95%CI)	P value	OR (95%CI)	P value
Age	1.067 (0.268-4.253)	0.927
Gender	1.607 (0.281-9.176)	0.593
Smoking	0.324 (0.081-1.302)	0.112
Drinking alcohol	0.444 (0.113-1.753)	0.247
Macroscopic types	7.167 (1.673-30.703)	0.008	9.291 (1.465-58.928)	0.018
Maximum tumor diameter	7.714 (0.911-65.352)	0.061
Histology	1.889 (0.482-7.396)	0.361
Depth of invasion	8.000 (1.575-40.632)	0.012	21.490 (1.815-254.398)	0.015
Venous/lymphatic invasion	1.884 (0.211-16.787)	0.570
Ascitic fluid	3.000 (0.346-25.993)	0.319
LINC01268	9.867 (1.873-51.974)	0.007	24.726 (2.167-282.097)	0.010

OR: Odds ratio; CI: Confidence interval.