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©The Author(s) 2022.
World J Gastrointest Oncol. Aug 15, 2022; 14(8): 1429-1445
Published online Aug 15, 2022. doi: 10.4251/wjgo.v14.i8.1429
Published online Aug 15, 2022. doi: 10.4251/wjgo.v14.i8.1429
Descriptive | Caricato et al[18] | Mirbagheri et al[28] | Beppu et al[32] | Lee et al[34] | Sun et al[35] | Cui et al[38] |
Negative/normal | LRG1 | LRG0 | - | pLRG0 | LRG0 | LRG0 |
Absence of histologically identifiable residual cancer and fibrosis extending through the different areas of the lymph node | Normal lymph nodes | - | LN-preserving normal nodal architecture without evidence of cancer cells or fibrosis was scored | Normal lymph node architecture without evidence of regression or cancer cells | Negative lymph node | |
Complete | LRG2 | LRG1 | LRG3 | pLRG1 | LRG1 | LRG1 |
Near complete pathologic response (pCR) | 100% fibrosis, no residual cancer | Total regression. No cancer cells, single cells or small groups of cancer | LN with 100% fibrosis | 100% fibrosis | Complete regression with no residual tumor cells | |
Subtotal | LRG3 | LRG2 | LRG2 | pLRG2 | LRG2 | LRG2 |
Presence of residual cancer cells with evident fibrosis | 75%-100% fibrosis, 0-25% cancer | Good regression. Residual cancer outgrown by fibrosis | LN with < 25% cancer cells | < 25% remaining cancer cells | Rare residual tumor cells | |
Partial | LRG4 | LRG3 | LRG1 | pLRG3 | LRG3 | LRG3 |
Poor response | 50%-75% fibrosis, 25%-50% cancer | Minor regression. Fibrosis outgrown by cancer or no fibrosis with extensive residual cancer | Scattered glandular elements with fibrosis | 25%-50% scattered glandular elements with fibrosis | Fibrosis outgrown by residual tumor cells | |
No regression | LRG5 | LRG4 | - | pLRG4 | LRG4 | LRG4 |
Nodal metastasis with absence of regressive changes | 25%-50% fibrosis, 50%-75% cancer | - | LN with > 50% cancer cells | > 50% viable cancer cells | Residual tumor cell outgrown by fibrosis | |
LRG5 | pLRG5 | LRG5 | LRG5 | |||
0-25% fibrosis, 75%-100% cancer | - | Complete replacement with cancer cells | Complete replacement with cancer cells | Absence of regression with no fibrosis |
- Citation: He L, Xiao J, Zheng P, Zhong L, Peng Q. Lymph node regression grading of locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy. World J Gastrointest Oncol 2022; 14(8): 1429-1445
- URL: https://www.wjgnet.com/1948-5204/full/v14/i8/1429.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v14.i8.1429