Review
Copyright ©The Author(s) 2022.
World J Gastrointest Oncol. Aug 15, 2022; 14(8): 1429-1445
Published online Aug 15, 2022. doi: 10.4251/wjgo.v14.i8.1429
Table 1 Examples for lymph node regression grading systems
Descriptive
Caricato et al[18]
Mirbagheri et al[28]
Beppu et al[32]
Lee et al[34]
Sun et al[35]
Cui et al[38]
Negative/normalLRG1LRG0-pLRG0LRG0LRG0
Absence of histologically identifiable residual cancer and fibrosis extending through the different areas of the lymph nodeNormal lymph nodes-LN-preserving normal nodal architecture without evidence of cancer cells or fibrosis was scoredNormal lymph node architecture without evidence of regression or cancer cellsNegative lymph node
CompleteLRG2LRG1LRG3pLRG1LRG1LRG1
Near complete pathologic response (pCR)100% fibrosis, no residual cancerTotal regression. No cancer cells, single cells or small groups of cancerLN with 100% fibrosis100% fibrosisComplete regression with no residual tumor cells
SubtotalLRG3LRG2LRG2pLRG2LRG2LRG2
Presence of residual cancer cells with evident fibrosis75%-100% fibrosis, 0-25% cancerGood regression. Residual cancer outgrown by fibrosisLN with < 25% cancer cells< 25% remaining cancer cellsRare residual tumor cells
PartialLRG4LRG3LRG1pLRG3LRG3LRG3
Poor response50%-75% fibrosis, 25%-50% cancerMinor regression. Fibrosis outgrown by cancer or no fibrosis with extensive residual cancerScattered glandular elements with fibrosis25%-50% scattered glandular elements with fibrosisFibrosis outgrown by residual tumor cells
No regressionLRG5LRG4-pLRG4LRG4LRG4
Nodal metastasis with absence of regressive changes25%-50% fibrosis, 50%-75% cancer-LN with > 50% cancer cells> 50% viable cancer cellsResidual tumor cell outgrown by fibrosis
LRG5pLRG5LRG5LRG5
0-25% fibrosis, 75%-100% cancer-Complete replacement with cancer cellsComplete replacement with cancer cellsAbsence of regression with no fibrosis