Clinical efficacy and prognostic risk factors of endoscopic radiofrequency ablation for gastric low-grade intraepithelial neoplasia

Table 1 The basic characteristics and endoscopic features of all 253 cases

	Curative	Relapse	Total	P value
Patients, n	188 (74.3)	65 (25.7)	253
Age, mean ± SD (yr)	58.51 ± 10.53	58.23 ± 8.33	58.43 ± 9.99	0.83
Sex, n (%)				0.24
Male	128 (68.1)	39 (60.0)	167 (66.0)
Female	60 (31.9)	26 (40.0)	86 (34.0)
Location of lesions, n (%)				0.08
Gastric fundus - cardia area	5 (2.7)	1 (1.5)	6 (2.4)
Gastric body	19 (10.1)	5 (7.7)	24 (9.5)
Angle of stomach	32 (17.0)	21 (32.3)	53 (20.9)
Antrum of the stomach - pylorus area	132 (70.2)	38 (58.5)	170 (67.2)
Ulceration	0	0	0
Helicobacter pylori infection, n (%)				< 0.001
Yes	8 (4.3)	37 (56.9)	45 (17.8)
No	180 (95.7)	28 (43.1)	208 (82.2)
Atrophy, n (%)				< 0.001
Yes	49 (26.1)	39 (60.0)	88 (34.8)
No	139 (73.9)	26 (40.0)	165 (65.2)
A course of disease, n (%)				< 0.001
< 1 yr	138 (73.4)	14 (21.5)	152 (60.1)
> 1 yr	50 (26.6)	51 (78.5)	101 (39.9)

Table 2 The data of all 253 cases that received radiofrequency ablation and completed follow-ups

Follow-up period	n	Curative, n (%)	Relapse, n (%)	Recurrence, n (%)	Progression, n (%)
3 mo	253	236 (93.3)	17 (6.7)	18 (7.1)	2 (0.8)
6 mo	208	193 (92.8)	15 (7.2)	11 (5.3)	0
1 yr	141	129 (91.5)	12 (8.5)	14 (9.9)	0
2 yr	93	84 (90.3)	9 (9.7)	8 (8.6)	1 (1.1)
3 yr	61	54 (88.5)	7 (11.5)	6 (9.8)	2 (3.3)
4 yr	28	24 (85.7)	4 (14.3)	4 (14.3)	0
5 yr	6	5 (83.3)	1 (16.7)	1 (16.7)	0

Table 3 Univariate and multivariate analysis of demographic and clinical features covariates for relapse

	Univariate		Multivariate
	P value	HR (95%CI)	P value	HR (95%CI)
Sex	0.43	0.817 (0.494-1.351)
Age	0.89	0.998 (0.974-1.023)
Location	0.29
Gastric body		0.674 (0.092-4.919)
Angle of stomach		1.242 (0.487-3.167)
Antrum of the stomach - pylorus area		1.644 (0.963-2.808)
H. pylori infection	< 0.001	6.053 (3.679-9.957)	< 0.001	2.662 (1.225-5.788)
Atrophy	< 0.001	2.136 (1.024-4.453)	0.597	1.170 (0.653-2.097)
Course of disease	< 0.001	5.482 (3.029-9.919)	0.013	2.662 (1.225-5.788)

H. pylori: Helicobacter pylori.